All Stories

  1. Therapeutic Trials in Alzheimer’s Disease: Where Are We Now?
  2. Fueling Alzheimer’s Disease: Where Does Immunometabolism Stand?
  3. MitoTempo protects against nε-carboxymethyl lysine-induced mitochondrial dyshomeostasis and neuronal cells injury
  4. Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer's disease
  5. Corrigendum: Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
  6. Mapping the lipidome in mitochondria‐associated membranes (MAMs) in an in vitro model of Alzheimer's disease
  7. Neuro–glia communication and glycolysis
  8. Current Advances in Mitochondrial Targeted Interventions in Alzheimer’s Disease
  9. Therapeutic potential of glutaminyl cyclases: Current status and emerging trends
  10. Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease
  11. Retinal imaging in animal models: Searching for biomarkers of neurodegeneration
  12. Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria
  13. A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
  14. WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose
  15. Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway
  16. Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease
  17. Hypoxic Preconditioning Averts Sporadic Alzheimer's Disease-Like Phenotype in Rats: A Focus on Mitochondria
  18. ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system
  19. Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats
  20. Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update
  21. Oxygen Sensing and Signaling in Alzheimer’s Disease: A Breathtaking Story!
  22. Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease
  23. Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease
  24. WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration
  25. IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis
  26. Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease
  27. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  28. PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
  29. Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort
  30. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
  31. Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease
  32. Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors
  33. Liraglutide Protects Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
  34. The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice
  35. Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones
  36. Cognitive Impairment in Obesity and Diabetes
  37. An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease
  38. Retinal thickness of the triple‐transgenic mice model of Alzheimer\’s disease at the age of one month
  39. Is Alzheimer’s disease an inflammasomopathy?
  40. Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area
  41. Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study
  42. Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer’s Disease
  43. Post-translational modifications in brain health and disease
  44. Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies
  45. Diabesity and brain disturbances: A metabolic perspective
  46. A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss
  47. The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel
  48. Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer’s Disease
  49. Can the retina show similar molecular and cellular changes as the brain in an animal model of Alzheimer’s disease?
  50. O-GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease
  51. Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
  52. Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington’s Disease
  53. Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology
  54. The beneficial role of exercise in mitigating doxorubicin-induced Mitochondrionopathy
  55. Sweet Mitochondria: A Shortcut to Alzheimer’s Disease
  56. Fingernail Trace Element Content in Environmentally Exposed Individuals and Its Influence on Their Cognitive Status in Ageing
  57. Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects
  58. Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats
  59. Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid
  60. Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements
  61. Diabesity and Brain Energy Metabolism: The Case of Alzheimer’s Disease
  62. Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!
  63. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology
  64. Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
  65. Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks
  66. Mini-Symposium: Energy Demand and Energy Supply in Alzheimer's Disease - Introduction
  67. Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine
  68. Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease
  69. Erratum
  70. Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells
  71. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  72. Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling
  73. Tackling Alzheimer’s Disease by Targeting Oxidative Stress and Mitochondria
  74. Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions
  75. Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells
  76. Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers
  77. Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers
  78. The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases
  79. Metabolic fingerprints in testicular biopsies from type 1 diabetic patients
  80. Endoplasmic reticulum stress
  81. Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy Menu
  82. Type 2 Diabetes Aggravates Alzheimer's Disease-Associated Vascular Alterations of the Aorta in Mice
  83. Daily consumption of white tea (Camellia sinensis (L.)) improves the cerebral cortex metabolic and oxidative profile in prediabetic Wistar rats
  84. Exercise-Induced Protection Against Aging and Neurodegenerative Diseases
  85. Cerebrovascular and mitochondrial abnormalities in Alzheimer’s disease: a brief overview
  86. Autophagy in Alzheimer’s disease: A Cleaning Service Out-of-order?
  87. Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease
  88. Vascular, Oxidative, and Synaptosomal Abnormalities During Aging and the Progression of Type 2 Diabetes
  89. Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
  90. The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
  91. Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells
  92. Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia
  93. Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats
  94. Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status
  95. Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells
  96. Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes
  97. Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
  98. Metformin and male reproduction: effects on Sertoli cell metabolism
  99. Alzheimer's Disease: An Overview☆
  100. Alzheimer's Disease
  101. Increased Susceptibility to Amyloid-β Toxicity in Rat Brain Microvascular Endothelial Cells under Hyperglycemic Conditions
  102. The Janus Face of Insulin in Brain
  103. Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?
  104. Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes
  105. Exposure to 2,4-dichlorophenoxyacetic acid alters glucose metabolism in immature rat Sertoli cells
  106. High-sugar diets, type 2 diabetes and Alzheimerʼs disease
  107. Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease
  108. Mitochondrial-Targeted Protective Properties of Isolated Diterpenoids fromSideritisspp. in Response to the Deleterious Changes Induced by H2O2
  109. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links
  110. Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies
  111. Molecular mechanisms beyond glucose transport in diabetes-related male infertility
  112. Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
  113. Mitochondrial Abnormalities in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease
  114. Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
  115. UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats
  116. Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease
  117. Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance
  118. Mechanism of inhibition of mitochondrial ATP synthase by 17β−Estradiol
  119. The impairment of insulin signaling in Alzheimer's disease
  120. Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile
  121. Alzheimer disease as a vascular disorder: Where do mitochondria fit?
  122. Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
  123. Impact of Diabetes in Blood-Testis and Blood-Brain Barriers: Resemblances and Differences
  124. Hormonal control of Sertoli cell metabolism regulates spermatogenesis
  125. Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin
  126. Oxidative Damage to RNA in Aging and Neurodegenerative Disorders
  127. Guidelines for the use and interpretation of assays for monitoring autophagy
  128. Association of Mitochondrial Signaling in Alzheimer’s Disease and Hypoxia
  129. Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities
  130. The role of iron as a mediator of oxidative stress in Alzheimer disease
  131. Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
  132. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover
  133. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease
  134. Mitochondrial Importance in Alzheimer’s, Huntington’s and Parkinson’s Diseases
  135. Glycogen Synthase Kinase 3: A Point of Integration in Alzheimer's Disease and a Therapeutic Target?
  136. Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1α
  137. Insulin in Central Nervous System: More than Just a Peripheral Hormone
  138. New Insights into the Mechanisms of Mitochondrial Preconditioning-Triggered Neuroprotection
  139. Oxidative Stress and Balance in Neurodegenerative Diseases
  140. Neurofilamentopathy in Neurodegenerative Diseases
  141. Mitophagy in Neurodegeneration: An Opportunity for Therapy?
  142. Effects of rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
  143. SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
  144. Mitochondria as Potential Targets in Antidiabetic Therapy
  145. Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen
  146. Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia
  147. Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters
  148. Autophagy in Alzheimer’s disease
  149. Effects of Estrogen in the Brain: Is it a Neuroprotective Agent in Alzheimers Disease?
  150. A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease
  151. Mitochondria: The Missing Link Between Preconditioning and Neuroprotection
  152. Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
  153. Mitochondrial preconditioning: a potential neuroprotective strategy
  154. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
  155. Mitochondria: A therapeutic target in neurodegeneration
  156. Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?
  157. Natural Oxidant Balance in Parkinson Disease
  158. Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes
  159. Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia
  160. Doxorubicin: The Good, the Bad and the Ugly Effect
  161. An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease
  162. RNA oxidation in Alzheimer disease and related neurodegenerative disorders
  163. Altered redox balance in disease: Can we change the new equilibria?
  164. Alzheimer’s Disease: An Overview
  165. Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease
  166. Food Deprivation Promotes Oxidative Imbalance in Rat Brain
  167. Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
  168. Oxidative Stress Signaling in Alzheimers Disease
  169. Mechanisms of Action of Metformin in Type 2 Diabetes and Associated Complications: An Overview
  170. Antioxidant Therapy in Alzheimers Disease: Theory and Practice
  171. Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage
  172. Metformin Protects the Brain Against the Oxidative Imbalance Promoted by Type 2 Diabetes
  173. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
  174. Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
  175. Nucleic acid oxidation in Alzheimer disease
  176. Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease
  177. Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson Diseases
  178. Oxidative RNA Damage and Neurodegeneration
  179. Metformin promotes isolated rat liver mitochondria impairment
  180. Alzheimer's Disease: A Lesson from Mitochondrial Dysfunction
  181. Soybean oil treatment impairs glucose-stimulated insulin secretion and changes fatty acid composition of normal and diabetic islets
  182. Errata
  183. Autophagocytosis of Mitochondria Is Prominent in Alzheimer Disease
  184. Vascular oxidative stress in Alzheimer disease
  185. Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
  186. Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease
  187. Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats
  188. Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
  189. Indices of Metabolic Dysfunction and Oxidative Stress
  190. Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
  191. The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics
  192. The Key Role of Oxidative Stress in Alzheimer's Disease
  193. Foreword: Mitochondria in Alzheimer disease
  194. Involvement of Oxidative Stress in Alzheimer Disease
  195. Telomeres and telomerase in Alzheimer’s disease: Epiphenomena or a new focus for therapeutic strategy?
  196. Therapeutic options in Alzheimer’s disease
  197. The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease
  198. Neuropathology in Alzheimer's Disease: Awaking from a Hundred-Year-Old Dream
  199. Insulin Attenuates Diabetes-Related Mitochondrial Alterations: A Comparative Study
  200. Presenilin mutation: A deadly first hit in Alzheimer disease
  201. Tamoxifen and Estradiol Interact with the Flavin Mononucleotide Site of Complex I Leading to Mitochondrial Failure
  202. CoQ10 therapy attenuates amyloid β-peptide toxicity in brain mitochondria isolated from aged diabetic rats
  203. Oxidative Stress: The Old Enemy in Alzheimers Disease Pathophysiology
  204. Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease
  205. Alzheimer's disease: an intracellular movement disorder?
  206. Redox metals and oxidative abnormalities in human prion diseases
  207. Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
  208. Neurodegenerative Pathways in Parkinsons Disease: Therapeutic Strategies
  209. Oxidative Stress and Neurodegeneration
  210. Therapeutic Opportunities in Alzheimer Disease: One for all or all for One?
  211. Chronological primacy of oxidative stress in Alzheimer disease
  212. Tau phosphorylation in Alzheimer's disease: pathogen or protector?
  213. A Second Look into the Oxidant Mechanisms in Alzheimers Disease
  214. Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats
  215. Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron
  216. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations
  217. Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen
  218. Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease
  219. Biphasic expression of lipin suggests dual roles in adipocyte development
  220. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease
  221. Neurofilament proteins in neurodegenerative diseases
  222. Therapeutic potential of oxidant mechanisms in Alzheimer’s disease
  223. Hydroxytamoxifen protects against oxidative stress in brain mitochondria
  224. Effect of Streptozotocin-Induced Diabetes on Rat Brain Mitochondria
  225. Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-  Exposure
  226. Effect of amyloid ?-peptide on permeability transition pore: A comparative study
  227. Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria
  228. Susceptibility to β-Amyloid-Induced Toxicity Is Decreased in Goto-Kakizaki Diabetic Rats: Involvement of Oxidative Stress