Contact

All Stories

  1. Stress-conditioned small extracellular vesicles from young cells to restore resilience in aging

    Article • Medical Hypotheses, March 2026, Elsevier

    Dr Marc Etienne Poirot

  2. The Phospholipid Bis(monoacylglycero)Phosphate Confers Antitumour Immunogenicity to Exosomes Secreted by Dendrogenin A, Which Activates Its Biosynthesis in Tumour Cells

    Article • Journal of Extracellular Vesicles, January 2026, Wiley

    Dr Marc Etienne Poirot

  3. 5,6-Epoxycholestanols Metabolism and Functions: Defining the Epoxycholestanoid (EChA) Family

    Article • January 2026, Wiley

    Dr Marc Etienne Poirot

  4. Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities

    Article • Ageing Research Reviews, January 2026, Elsevier

    Dr Marc Etienne Poirot

  5. Liver X Receptors and the Hallmarks of Aging: From Molecular Mechanisms to Therapeutic Opportunities

    Article • October 2025, Wiley

    Dr Marc Etienne Poirot

  6. Oxysterols at the Crossroads of Cholesterol Metabolism and Cancer

    Article • October 2025, Wiley

    Dr Marc Etienne Poirot

  7. Liver X Receptors and the Hallmarks of Aging: From Molecular Mechanisms to Therapeutic Opportunities

    Article • October 2025, Wiley

    Dr Marc Etienne Poirot

  8. Current advances in phytosterol free forms and esters: Classification, biosynthesis, chemistry, and detection

    Article • Steroids, December 2024, Elsevier

    Dr Marc Etienne Poirot

  9. 11th ENOR meeting: Oxysterols in human health and diseases

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2024, Elsevier

    Dr Marc Etienne Poirot

  10. Editorial: Lipids, lipid oxidation, and cancer: from biology to therapeutics

    Article • Frontiers in Oncology, April 2024, Frontiers

    Dr Marc Etienne Poirot

  11. The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases

    Article • December 2023, Springer Science + Business Media

    Dr Marc Etienne Poirot

  12. 27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

    Article • Journal of Lipid Research, December 2023, Elsevier

    Dr Marc Etienne Poirot

  13. Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2023, Elsevier

    Dr Marc Etienne Poirot

  14. 27-hydroxylation of oncosterone by CYP27A1 switchs its activity from pro-tumor to anti-tumor

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Dr Marc Etienne Poirot

  15. Is cholesterol a risk factor for breast cancer incidence and outcome?

    Article • The Journal of Steroid Biochemistry and Molecular Biology, September 2023, Elsevier

    Dr Marc Etienne Poirot

  16. European Network for oxysterol research (ENOR): 10th ENOR symposium – Web meeting

    Article • Steroids, July 2023, Elsevier

    Dr Marc Etienne Poirot

  17. An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management

    Article • Journal of Personalized Medicine, April 2023, MDPI AG

    Dr Marc Etienne Poirot

  18. Vitamin E components give a multitude of oxidation products.

    Article • Food Bioscience, October 2022, Elsevier

    Dr Marc Etienne Poirot

  19. Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes

    Article • Autophagy, September 2022, Taylor & Francis

    Dr Marc Etienne Poirot

  20. Celebrating the 10th anniversary of the creation of the European Network for Oxysterol Research (ENOR)

    Article • The Journal of Steroid Biochemistry and Molecular Biology, July 2022, Elsevier

    Dr Marc Etienne Poirot

  21. Cholesterol is a lipid producing signaling molecules controlling Aging

    Article • Ageing Research Reviews, May 2022, Elsevier

    Dr Marc Etienne Poirot

  22. Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

    Article • Journal of Extracellular Vesicles, April 2022, Wiley

    Dr Marc Etienne Poirot

  23. Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: A systematic review and meta-analysis of preclinical models

    Article • Biochemical Pharmacology, February 2022, Elsevier

    Dr Marc Etienne Poirot

  24. Sterol metabolism and cancer

    Article • Biochemical Pharmacology, February 2022, Elsevier

    Dr Marc Etienne Poirot

  25. Acknowledgement to Reviewers of Immunometabolism in 2021

    Article • Immunometabolism, January 2022, Wolters Kluwer Health

    Dr Marc Etienne Poirot

  26. European network for oxysterol research (ENOR): 10 th anniversary

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2021, Elsevier

    Dr Marc Etienne Poirot

  27. Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models

    Article • June 2021, Cold Spring Harbor Laboratory Press

    Dr Marc Etienne Poirot

  28. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Prof. Dr. Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro, Dr Jorge F Quarleri, Professor hengyi xiao, Dr. Yanzhuang Wang, Prof Giacinto Bagetta, Dr. Ann M Wehman, Dr Pawan Sharma, Dr Anna Krasnodembskaya, Dr Francesca Finetti, Nicoletta Filigheddu, Professor Javier González-Gallego, Professor Günther Weindl, Professor Nektarios Tavernarakis

  29. Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia

    Article • Cancers, October 2020, MDPI AG

    Dr Marc Etienne Poirot

  30. The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets

    Article • British Journal of Pharmacology, August 2020, Wiley

    Dr Marc Etienne Poirot

  31. Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

    Article • Cancers, June 2020, MDPI AG

    Dr Marc Etienne Poirot

  32. The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets

    Article • May 2020, Authorea, Inc.

    Dr Marc Etienne Poirot

  33. Oxysterols and sterols: From lipidomics to food sciences

    Article • The Journal of Steroid Biochemistry and Molecular Biology, February 2020, Elsevier

    Dr Marc Etienne Poirot

  34. Vitamin E: an overview

    Article • January 2020, Elsevier

    Dr Marc Etienne Poirot

  35. A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2019, Elsevier

    Dr Marc Etienne Poirot

  36. Oxysterols: An expanding family of structurally diversified bioactive steroids

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 2019, Elsevier

    Dr Marc Etienne Poirot

  37. The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, September 2019, Elsevier

    Dr Marc Etienne Poirot

  38. Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis

    Article • The Journal of Steroid Biochemistry and Molecular Biology, June 2019, Elsevier

    Dr Marc Etienne Poirot

  39. Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis

    Article • Bioorganic Chemistry, June 2019, Elsevier

    Dr Marc Etienne Poirot

  40. HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris

    Article • Molecules, January 2019, MDPI AG

    Dr Marc Etienne Poirot

  41. Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3β,5α-diol (OCDO), a tumor promoter and cholesterol metabolite

    Article • Biochimie, October 2018, Elsevier

    Dr Marc Etienne Poirot

  42. The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer

    Article • Cancer Research, August 2018, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  43. Extracellular vesicles: lipids as key components of their biogenesis and functions

    Article • Journal of Lipid Research, August 2018, Elsevier

    Dr Marc Etienne Poirot

  44. The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers

    Article • Biochemical Pharmacology, July 2018, Elsevier

    Dr Marc Etienne Poirot

  45. Abstract 5238: Characterization of the enzyme generating the cholesterol metabolite and tumor suppressor dendrogenin A in the breast and its deregulations in breast cancer

    Article • Cancer Research, July 2018, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  46. Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment

    Article • Autophagy, March 2018, Taylor & Francis

    Dr Marc Etienne Poirot

  47. Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation

    Article • Biomedicines, February 2018, MDPI AG

    Dr Marc Etienne Poirot

  48. Meet Our Editorial Board Member

    Article • The Natural Products Journal, February 2018, Bentham Science Publishers

    Dr Marc Etienne Poirot

  49. Dendrogenin A (DDA) is a cholesterol metabolite with potent anticancer properties

    Article • Nature Communications, December 2017, Nature

    Dr Marie Tosolini, Dr Marc Etienne Poirot

  50. Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM-mediated autophagy, cell differentiation and death

    Article • Biochemical Pharmacology, November 2017, Elsevier

    Dr Marc Etienne Poirot

  51. Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

    Article • Proceedings of the National Academy of Sciences, October 2017, Proceedings of the National Academy of Sciences

    Dr Marc Etienne Poirot

  52. Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry

    Article • Chemistry and Physics of Lipids, October 2017, Elsevier

    Dr Marc Etienne Poirot

  53. Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS

    Article • Chemistry and Physics of Lipids, October 2017, Elsevier

    Dr Marc Etienne Poirot

  54. Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2017, Elsevier

    Dr Marc Etienne Poirot

  55. From tamoxifen to dendrogenin A: The discovery of a mammalian tumor suppressor and cholesterol metabolite

    Article • Biochimie, November 2016, Elsevier

    Dr Marc Etienne Poirot

  56. When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite1

    Article • Biochemical Society Transactions, April 2016, Portland Press Ltd.

    Dr Marc Etienne Poirot

  57. Erratum

    Article • Autophagy, February 2016, Taylor & Francis

    Dr Janos KristonVizi, Juan Segura-Aguilar, Professor Nektarios Tavernarakis, Dr Reinhard Dechant, Dr Vasilis J Promponas, Professor Marc Lecuit, Professor Paula I. Moreira, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Professor Jean-François Beaulieu, Shile Huang, Maria João Sousa, Professor Godefridus J Peters, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Professor Abdel Halim Harrath, Professor Günther Weindl, Dr Marc Etienne Poirot

  58. Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds

    Article • Frontiers in Oncology, January 2016, Frontiers

    Dr Marc Etienne Poirot

  59. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Article • Autophagy, January 2016, Taylor & Francis

    Professor CIRO ISIDORO, Dr Akira Matsuura, Prof Hirokazu Arimoto, Professor Marc Diederich, Maria Vaccaro, Professor Abdel Halim Harrath, Professor Hyun Kyu Song, Dr Takeshi Noda, Dr Regina Menezes, Dr Janos KristonVizi, Cristina Muñoz-Pinedo, Professor Nektarios Tavernarakis, Juan Segura-Aguilar, Professor Marc Lecuit, Leonardo Travassos, Prof Robert Bryson-Richardson, Isabelle Dugail, PD Dipl.-Ing. Dr. techn. Werner J Kovacs, Dr Luca Galluzzi, Dr Reinhard Dechant, Dr. Sandra Moreno, Maurizio Molinari, Dr Vasilis J Promponas, Professor Günther Weindl, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Maria João Sousa, Dr Janna Morrison, Professor Mark Cragg, Executive Director, The Hormel Institute Robert Clarke, Dr Eleonora García Véscovi, Paula Ludovico, Professor Jean-François Beaulieu, Shile Huang, Professor George Perry, Professor Godefridus J Peters, Shuo-Chien Ling, Professor Jiwu Wei, Deepak Shukla, Dave Bridges

  60. dendrogenin A: a good cholesterol metabolite against cancer

    Article • Current Medicinal Chemistry, October 2015, Bentham Science Publishers

    Dr Marc Etienne Poirot

  61. Abstract 1165: Identification of a cholesterol onco-metabolite, promoter of tumor in breast cancers, and of the enzyme involved in its biosynthesis

    Article • Cancer Research, August 2015, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  62. Dendrogenin A and B two new steroidal alkaloids increasing neural responsiveness in the deafened guinea pig

    Article • Frontiers in Aging Neuroscience, July 2015, Frontiers

    Dr Marc Etienne Poirot

  63. Cholesterol metabolites exported from human brain

    Article • Steroids, July 2015, Elsevier

    Dr Marc Etienne Poirot

  64. Abstract P3-05-12: Circulating oxysterol metabolites as potential new surrogate markers for hormonotherapy in patients with hormone receptor-positive breast cancer? A pilot study

    Article • Cancer Research, May 2015, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  65. Dendrogenin_A : A Natural Liver X Receptor Modulator for the Treatment of Acute Myeloid Leukemia

    Article • Blood, December 2014, American Society of Hematology

    Dr Marc Etienne Poirot

  66. The fatal ADORAtion of adenosine based cyclic dinucleotides

    Article • Molecular and Cellular Biology, November 2014, ASM Journals

    Dr Marie Tosolini, Dr Marc Etienne Poirot

  67. One step synthesis of 6-oxo-cholestan-3β,5α-diol

    Article • Biochemical and Biophysical Research Communications, April 2014, Elsevier

    Dr Marc Etienne Poirot

  68. The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells

    Article • Biochemical and Biophysical Research Communications, April 2014, Elsevier

    Dr Marc Etienne Poirot

  69. Cholesterol and Cancer, in the Balance

    Article • Science, March 2014, American Association for the Advancement of Science

    Dr Marc Etienne Poirot

  70. Emerging concepts on the role of exosomes in lipid metabolic diseases

    Article • Biochimie, January 2014, Elsevier

    Dr Marc Etienne Poirot

  71. Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, January 2014, Elsevier

    Dr Marc Etienne Poirot

  72. Generation of whole-body scintigraphic images with new GATE output capacities

    Article • October 2013, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Marc Etienne Poirot

  73. Progesterone and a phospholipase inhibitor increase the endosomal bis(monoacylglycero)phosphate content and block HIV viral particle intercellular transmission

    Article • Biochimie, September 2013, Elsevier

    Dr Marc Etienne Poirot

  74. 5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells

    Article • Biochemical Pharmacology, July 2013, Elsevier

    Dr Marc Etienne Poirot

  75. Oxysterols and related sterols: Implications in pharmacology and pathophysiology

    Article • Biochemical Pharmacology, July 2013, Elsevier

    Dr Marc Etienne Poirot

  76. Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism

    Article • Oncotarget, June 2013, Impact Journals, LLC

    Dr Marc Etienne Poirot

  77. Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties

    Article • Nature Communications, May 2013, Nature

    Dr Thomas Filleron, Dr Marc Etienne Poirot

  78. Improved realism of hybrid mouse models may not be sufficient to generate reference dosimetric data

    Article • Medical Physics, April 2013, Wiley

    Dr Marc Etienne Poirot

  79. Abstract 1662: Dendrogenin A is a newly identified mammalian steroidal alkaloid that induced autophagic cell death in melanoma cells through an LXRbeta-, Nur77- and Nor1-dependent way.

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  80. Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer

    Article • Biochimie, March 2013, Elsevier

    Dr Marc Etienne Poirot

  81. Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A

    Article • Biochimie, March 2013, Elsevier

    Dr Marc Etienne Poirot

  82. Cholesterol epoxide hydrolase and cancer

    Article • Current Opinion in Pharmacology, December 2012, Elsevier

    Dr Marc Etienne Poirot

  83. Cholesterol metabolism and cancer: the good, the bad and the ugly

    Article • Current Opinion in Pharmacology, December 2012, Elsevier

    Dr Marc Etienne Poirot

  84. Cholesterol metabolism and resistance to tamoxifen

    Article • Current Opinion in Pharmacology, December 2012, Elsevier

    Dr Marc Etienne Poirot

  85. MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

    Article • Autophagy, July 2012, Taylor & Francis

    Dr Marc Etienne Poirot

  86. Guidelines for the use and interpretation of assays for monitoring autophagy

    Article • Autophagy, April 2012, Taylor & Francis

    Dave Bridges, Professor CIRO ISIDORO, Professor George Perry, Dr Takeshi Noda, Professor Nektarios Tavernarakis, Matthias Gaestel, Dr Francesca Demarchi, Maria Vaccaro, Juan Segura-Aguilar, Leonardo Travassos, Manoj B Menon, Isabelle Dugail, Dr Legembre Patrick, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Professor Godefridus J Peters, Professor Brigitte Galliot, Professor Luca Scorrano

  87. Abstract 956: The liver-X-receptor-α is involved in the induction by Tamoxifen of breast cancer cell differentiation and death

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  88. Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor

    Article • Biochemical Pharmacology, March 2012, Elsevier

    Dr Marc Etienne Poirot

  89. Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles

    Article • Journal of Lipid Research, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Marc Etienne Poirot

  90. Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands

    Article • Chemistry and Physics of Lipids, September 2011, Elsevier

    Dr Marc Etienne Poirot

  91. Exosomes as intercellular signalosomes and pharmacological effectors

    Article • Biochemical Pharmacology, May 2011, Elsevier

    Dr Marc Etienne Poirot

  92. Abstract 938: Discovery of Dendrogenin A as the first endogenous alkylaminooxysterol present in mammals with potent cell differentiation and anticancer activity

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  93. Four decades of discovery in breast cancer research and treatment an interview with V. Craig Jordan

    Article • The International Journal of Developmental Biology, January 2011, UBC Press

    Dr Marc Etienne Poirot

  94. R42 – Oral Un « bon et mauvais cholestérol » pour la thérapie et dans la pathophysiologie des cancers : les cholestérols époxydes et leurs dérivés sous les feux de la rampe

    Article • Bulletin du Cancer, October 2010, Elsevier

    Dr Marc Etienne Poirot

  95. R44: Médiateurs lipidiques et cancer : les exosomes comme « signalosomes » intercellulaires transporteurs de prostaglandines

    Article • Bulletin du Cancer, October 2010, Elsevier

    Dr Marc Etienne Poirot

  96. R167 - Oral, Club Mex-H Quantification du volume tumoral résiduel des cancers du rectum post-radiochimiothérapie par histomorphométrie quantitative

    Article • Bulletin du Cancer, October 2010, Elsevier

    Dr Marc Etienne Poirot

  97. R92: Intérêt de la modélisation moléculaire dans le développement de nouveaux radiopharmaceutiques en oncologie nucléaire

    Article • Bulletin du Cancer, October 2010, Elsevier

    Dr Marc Etienne Poirot

  98. Auraptene Is an Inhibitor of Cholesterol Esterification and a Modulator of Estrogen Receptors

    Article • Molecular Pharmacology, August 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Marc Etienne Poirot

  99. Correction for de Medina et al., Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands

    Article • Proceedings of the National Academy of Sciences, July 2010, Proceedings of the National Academy of Sciences

    Dr Marc Etienne Poirot

  100. Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands

    Article • Proceedings of the National Academy of Sciences, July 2010, Proceedings of the National Academy of Sciences

    Dr Marc Etienne Poirot

  101. Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: From molecular modeling to in vivo evaluation

    Article • Bioorganic & Medicinal Chemistry, July 2010, Elsevier

    Dr Marc Etienne Poirot

  102. Ciblage peptidique en oncologie nucléaire : intérêt de la modélisation moléculaire

    Article • Médecine Nucléaire, May 2010, Elsevier

    Dr Marc Etienne Poirot

  103. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

    Article • Journal of Lipid Research, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Marc Etienne Poirot

  104. Abstract 2918: Molecular identification of the cholesterol-5,6-epoxide hydrolase: A new target for selective estrogen receptor modulators and unsaturated fatty acids

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  105. Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting

    Article • European Journal of Medicinal Chemistry, February 2010, Elsevier

    Dr Marc Etienne Poirot

  106. Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases

    Article • Journal of Medicinal Chemistry, December 2009, American Chemical Society (ACS)

    Dr Marc Etienne Poirot

  107. Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation

    Article • Autophagy, October 2009, Taylor & Francis

    Dr Marc Etienne Poirot

  108. Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism

    Article • Cell Death and Differentiation, June 2009, Springer Science + Business Media

    Dr Marc Etienne Poirot

  109. Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion

    Article • Journal of Lipid Research, June 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Marc Etienne Poirot

  110. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism

    Article • Molecular Cancer Therapeutics, December 2008, American Association for Cancer Research (AACR)

    Dr Marc Etienne Poirot

  111. Structure-based identification of ER and ACAT as molecular targets involved in the chemopreventive activity of the citrus auraptene

    Article • Planta Medica, July 2008, Thieme Publishing Group

    Dr Marc Etienne Poirot

  112. Preclinical evaluation of new radioligand of cholecystokinin/gastrin receptors in endocrine tumors xenograft nude mice

    Article • Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment, February 2007, Elsevier

    Dr Marc Etienne Poirot

  113. Insights into the Cholecystokinin 2 Receptor Binding Site and Processes of Activation

    Article • Molecular Pharmacology, September 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Marc Etienne Poirot

  114. The Prototypical Inhibitor of Cholesterol Esterification, Sah 58-035 [3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide], Is an Agonist of Estrogen Receptors

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Marc Etienne Poirot

  115. Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways

    Article • November 2005, Springer Science + Business Media

    Dr Marc Etienne Poirot

  116. Synthesis and Biological Properties of New Stilbene Derivatives of Resveratrol as New Selective Aryl Hydrocarbon Modulators

    Article • Journal of Medicinal Chemistry, January 2005, American Chemical Society (ACS)

    Dr Marc Etienne Poirot

  117. Multiple Targeting by the Antitumor Drug Tamoxifen: A Structure-Activity Study

    Article • Current Medicinal Chemistry - Anti-Cancer Agents, November 2004, Bentham Science Publishers

    Professor Gilles Favre, Dr Marc Etienne Poirot

  118. Molecular Characterization of the Microsomal Tamoxifen Binding Site

    Article • Journal of Biological Chemistry, June 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Marc Etienne Poirot

  119. Tamoxifen Is a Potent Inhibitor of Cholesterol Esterification and Prevents the Formation of Foam Cells

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Marc Etienne Poirot

  120. High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor

    Article • Oncogene, September 2003, Springer Science + Business Media

    Dr Marc Etienne Poirot

  121. Identification of Tyrosine 189 and Asparagine 358 of the Cholecystokinin 2 Receptor in Direct Interaction with the Crucial C-Terminal Amide of Cholecystokinin by Molecular Modeling, Site-Directed Mutagenesis, and Structure/Affinity Studies

    Article • Molecular Pharmacology, May 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Marc Etienne Poirot

  122. Contrasting Effects of Prenyltransferase Inhibitors on Estrogen-Dependent Cell Cycle Progression and Estrogen Receptor-Mediated Transcriptional Activity in MCF-7 Cells

    Article • Endocrinology, March 2003, Endocrine Society

    Professor Gilles Favre, Dr Marc Etienne Poirot

  123. Insulin and estrogen receptor ligand influence the FGF-2 activities in MCF-7 breast cancer cells

    Article • Biochemical Pharmacology, February 2003, Elsevier

    Dr Marc Etienne Poirot

  124. Identification of Two Tamoxifen Target Proteins by Photolabeling with 4-(2-Morpholinoethoxy)benzophenone

    Article • Bioconjugate Chemistry, July 2002, American Chemical Society (ACS)

    Dr Marc Etienne Poirot

  125. Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aorta

    Article • Cardiovascular Research, June 2001, European Society of Cardiology

    Dr Marc Etienne Poirot

  126. Synthesis, binding and structure–affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS)

    Article • Bioorganic & Medicinal Chemistry, August 2000, Elsevier

    Dr Marc Etienne Poirot

  127. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor

    Article • Biochemical Pharmacology, December 1999, Elsevier

    Dr Marc Etienne Poirot

  128. Modifications of benzylphenoxy ethanamine antiestrogen molecules: influence affinity for antiestrogen binding site (AEBS) and cell cytotoxicity

    Article • Biochemical Pharmacology, March 1999, Elsevier

    Dr Marc Etienne Poirot

  129. Different populations of progesterone receptor–steroid complexes in binding to specific DNA sequences: effects of salts on kinetics and specificity

    Article • The Journal of Steroid Biochemistry and Molecular Biology, November 1998, Elsevier

    Dr Marc Etienne Poirot

  130. Microsomal epoxide hydrolase of rat liver is a subunit of theanti-oestrogen-binding site

    Article • Biochemical Journal, August 1998, Portland Press Ltd.

    Dr Marc Etienne Poirot

  131. Characterization of the Membranous Antiestrogen Binding Protein: I Partial purification of the protein in its active state

    Article • Journal of Receptor Research, January 1994, Taylor & Francis

    Dr Marc Etienne Poirot

  132. Characterization of the Membranous Antiestrogen Binding Protein: II Purification to homogeneity

    Article • Journal of Receptor Research, January 1994, Taylor & Francis

    Dr Marc Etienne Poirot

  133. Characterization of a benzyl-phenoxy-ethanamine binding protein in Trypanosoma equiperdum and the possible relation between binding affinity and trypanocidal activity

    Article • Molecular and Biochemical Parasitology, April 1993, Elsevier

    Dr Marc Etienne Poirot

  134. Cytosolic Type II Estrogen Binding Site in Rat Uterus: Specific Photolabeling with Estrone

    Article • Journal of Receptor Research, January 1992, Taylor & Francis

    Dr Marc Etienne Poirot

  135. The anti-proliferative properties of 4-benzylphenoxy ethanamine derivatives are mediated by the anti-estrogen binding site (ABS), whereas the anti-estrogenic effects of trifluopromazine are not

    Article • Biochemical Pharmacology, August 1990, Elsevier

    Dr Marc Etienne Poirot

  136. Further evidence for a biological role of anti-estrogen-binding sites in mediating the growth inhibitory action of diphenylmethane derivatives

    Article • Chemico-Biological Interactions, January 1988, Elsevier

    Dr Marc Etienne Poirot