All Stories

  1. Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death

    Article • JCI Insight, January 2026, American Society for Clinical Investigation

    MD, PhD Pierre-Louis Tharaux

  2. A red blood cell-derived lipid maintains blood pressure and cardiac function.

    Article • Proceedings of the National Academy of Sciences, January 2026, Proceedings of the National Academy of Sciences

    Eric Camerer, MD, PhD Pierre-Louis Tharaux

  3. When YAP is hyperactivated in podocytes, it persistently “yaps,” disrupting the quiescence of neighboring glomerular cells

    Article • Kidney International, December 2025, Elsevier

    MD, PhD Pierre-Louis Tharaux

  4. Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome

    Article • Blood, October 2025, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  5. Perturbation of the circadian clock in chronic diseases involving organ fibrosis

    Article • Journal of Clinical Investigation, October 2025, American Society for Clinical Investigation

    MD, PhD Pierre-Louis Tharaux

  6. Mineralocorticoid receptor inhibition protects from severe forms of kidney diseases.

    Article • Kidney International, September 2025, Elsevier

    MD, PhD Pierre-Louis Tharaux

  7. Time course profiling of the kynurenine pathway activity in a pig model of crescentic glomerulonephritis

    Article • BMC Nephrology, August 2025, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  8. Pathology-oriented multiplexing enables integrative disease mapping

    Article • Nature, July 2025, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  9. Blood-borne sphingosine 1-phosphate maintains vascular resistance and cardiac function

    Article • January 2025, Cold Spring Harbor Laboratory Press

    MD, PhD Pierre-Louis Tharaux

  10. A macrophage-smooth muscle cell axis influences vascular remodeling through activation of the EGFR pathway in giant cell arteritis

    Article • November 2024, Cold Spring Harbor Laboratory Press

    MD, PhD Pierre-Louis Tharaux

  11. BMP9 is a key player in endothelial identity and its loss is sufficient to induce arteriovenous malformations

    Article • Cardiovascular Research, March 2024, Oxford University Press (OUP)

    MD, PhD Pierre-Louis Tharaux

  12. Vasorin as an actor of bone turnover?

    Article • Journal of Cellular Physiology, March 2024, Wiley

    MD, PhD Pierre-Louis Tharaux

  13. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

    Article • EClinicalMedicine, March 2024, Elsevier

    MD, PhD Pierre-Louis Tharaux

  14. VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation

    Article • Nature Communications, January 2024, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  15. More rapid blood interferon α2 decline in fatal versus surviving COVID-19 patients

    Article • Frontiers in Immunology, November 2023, Frontiers

    MD, PhD Pierre-Louis Tharaux

  16. Risk factors for thromboembolic events in patients hospitalized for COVID-19 pneumonia in a general ward and requiring treatment with oxygen

    Article • Postgraduate Medical Journal, November 2023, Oxford University Press (OUP)

    MD, PhD Pierre-Louis Tharaux

  17. Use of covid-19 convalescent plasma to treat patients admitted to hospital for covid-19 with or without underlying immunodeficiency: open label, randomised clinical trial

    Article • BMJ Medicine, October 2023, BMJ

    MD, PhD Pierre-Louis Tharaux

  18. Podocyte Injury in Diabetic Kidney Disease in Mouse Models Involves TRPC6-mediated Calpain Activation Impairing Autophagy

    Article • Journal of the American Society of Nephrology, September 2023, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  19. B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease

    Article • Clinical Science, September 2023, Portland Press Ltd.

    MD, PhD Pierre-Louis Tharaux

  20. Correction: Autophagy protein 5 controls flow-dependent endothelial functions

    Article • Cellular and Molecular Life Sciences, September 2023, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  21. Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub‐Saharan Africa (the BIOCADRE study)

    Article • British Journal of Haematology, August 2023, Wiley

    MD, PhD Pierre-Louis Tharaux

  22. Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study

    Article • The Lancet, August 2023, Elsevier

    MD, PhD Pierre-Louis Tharaux

  23. Autophagy protein 5 controls flow-dependent endothelial functions

    Article • Cellular and Molecular Life Sciences, July 2023, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  24. From bench to bedside: lessons learned from translational podocyte research

    Article • Kidney International, June 2023, Elsevier

    MD, PhD Pierre-Louis Tharaux

  25. Renal control of life-threatening malarial anemia

    Article • Cell Reports, February 2023, Elsevier

    MD, PhD Pierre-Louis Tharaux

  26. Type IV Collagen and SOX9 Are Molecular Targets of BET Inhibition in Experimental Glomerulosclerosis

    Article • International Journal of Molecular Sciences, December 2022, MDPI AG

    MD, PhD Pierre-Louis Tharaux

  27. Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice

    Article • Science Translational Medicine, December 2022, American Association for the Advancement of Science

    MD, PhD Pierre-Louis Tharaux

  28. MicroRNAs in kidney injury and disease

    Article • Nature Reviews Nephrology, August 2022, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  29. Reply: COVID-19 drug research and the cohort multiple randomised controlled trial design

    Article • European Respiratory Journal, July 2022, European Respiratory Society (ERS)

    olivier Hermine, MD, PhD Pierre-Louis Tharaux

  30. Vasorin plays a critical role in vascular smooth muscle cells and arterial functions

    Article • Journal of Cellular Physiology, July 2022, Wiley

    MD, PhD Pierre-Louis Tharaux

  31. Should we consider calcimimetics as a therapeutic option for nephrotic syndrome?

    Article • Kidney International, June 2022, Elsevier

    MD, PhD Pierre-Louis Tharaux

  32. ScoMorphoFISH: A deep learning enabled toolbox for single‐cell single‐mRNA quantification and correlative (ultra‐)morphometry

    Article • Journal of Cellular and Molecular Medicine, May 2022, Wiley

    MD, PhD Pierre-Louis Tharaux

  33. The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

    Article • Proceedings of the National Academy of Sciences, May 2022, Proceedings of the National Academy of Sciences

    MD, PhD Pierre-Louis Tharaux, Professor Lorenzo Piemonti

  34. FIBER-ML, an Open-Source Supervised Machine Learning Tool for Quantification of Fibrosis in Tissue Sections

    Article • American Journal Of Pathology, May 2022, Elsevier

    MD, PhD Pierre-Louis Tharaux

  35. The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses

    Article • Journal of Autoimmunity, May 2022, Elsevier

    MD, PhD Pierre-Louis Tharaux

  36. Tocilizumab plus dexamethasone versus dexamethasone in patients with moderate-to-severe COVID-19 pneumonia: A randomised clinical trial from the CORIMUNO-19 study group

    Article • EClinicalMedicine, April 2022, Elsevier

    MD, PhD Pierre-Louis Tharaux

  37. Effect of interleukin-6 receptor antagonists in critically ill adult patients with COVID-19 pneumonia: two randomised controlled trials of the CORIMUNO-19 Collaborative Group

    Article • European Respiratory Journal, February 2022, European Respiratory Society (ERS)

    olivier Hermine, MD, PhD Pierre-Louis Tharaux

  38. Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort

    Article • Science Translational Medicine, January 2022, American Association for the Advancement of Science

    MD, PhD Pierre-Louis Tharaux

  39. A Protective Inter-Organ Communication Response Against Life-Threatening Malarial Anemia

    Article • January 2022, Cold Spring Harbor Laboratory Press

    MD, PhD Pierre-Louis Tharaux

  40. Behavioural immune landscapes of inflammation

    Article • Nature, January 2022, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  41. Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial

    Article • The Lancet Rheumatology, January 2022, Elsevier

    MD, PhD Pierre-Louis Tharaux

  42. Severe COVID-19 is associated with hyperactivation of the alternative complement pathway

    Article • Journal of Allergy and Clinical Immunology, November 2021, Elsevier

    MD, PhD Pierre-Louis Tharaux

  43. PodoSighter: A Cloud-Based Tool for Label-Free Podocyte Detection in Kidney Whole-Slide Images

    Article • Journal of the American Society of Nephrology, September 2021, American Society of Nephrology

    Pinaki Sarder, MD, PhD Pierre-Louis Tharaux

  44. Effectiveness of Tocilizumab in Patients Hospitalized With COVID-19

    Article • JAMA Internal Medicine, September 2021, American Medical Association (AMA)

    MD, PhD Pierre-Louis Tharaux

  45. Parietal epithelial cell dysfunction in crescentic glomerulonephritis

    Article • Cell and Tissue Research, August 2021, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  46. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

    Article • Science Immunology, August 2021, American Association for the Advancement of Science

    MD, PhD Pierre-Louis Tharaux, Eric Hoste, Professor Lorenzo Piemonti

  47. Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19

    Article • JAMA, August 2021, American Medical Association (AMA)

    MD, PhD Pierre-Louis Tharaux

  48. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs

    Article • Journal of Clinical Investigation, June 2021, American Society for Clinical Investigation

    MD, PhD Pierre-Louis Tharaux

  49. Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity

    Article • PLOS One, May 2021, PLOS

    MD, PhD Pierre-Louis Tharaux

  50. Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease

    Article • Frontiers in Medicine, March 2021, Frontiers

    MD, PhD Pierre-Louis Tharaux

  51. 3D-printed protected face shields for health care workers in Covid-19 pandemic

    Article • American Journal of Infection Control, March 2021, Elsevier

    MD, PhD Pierre-Louis Tharaux

  52. Calpastatin prevents Angiotensin II-mediated podocyte injury through maintenance of autophagy

    Article • Kidney International, March 2021, Elsevier

    MD, PhD Pierre-Louis Tharaux

  53. Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke

    Article • Circulation Research, February 2021, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  54. Cardiomyopathie toxique induite par l’hydroxychloroquine compliquant le traitement d’un lupus systémique

    Article • Annales de Pathologie, February 2021, Elsevier

    MD, PhD Pierre-Louis Tharaux

  55. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Prof. Dr. Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro, Dr Jorge F Quarleri, Professor hengyi xiao, Dr. Yanzhuang Wang, Prof Giacinto Bagetta, Dr. Ann M Wehman, Dr Pawan Sharma, Dr Anna Krasnodembskaya, Dr Francesca Finetti, Nicoletta Filigheddu, Professor Javier González-Gallego, Professor Günther Weindl, Professor Nektarios Tavernarakis

  56. Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial

    Article • The Lancet Respiratory Medicine, January 2021, Elsevier

    MD, PhD Pierre-Louis Tharaux, CRANSAC Amélie

  57. Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia

    Article • JAMA Internal Medicine, January 2021, American Medical Association (AMA)

    MD, PhD Pierre-Louis Tharaux, CRANSAC Amélie

  58. Sunitinib-induced cardiac hypertrophy and the endothelin axis

    Article • Theranostics, January 2021, Ivyspring International Publisher

    MD, PhD Pierre-Louis Tharaux

  59. Podocyte healthy self-eating boosted by a spermidine meal?

    Article • Kidney International, December 2020, Elsevier

    MD, PhD Pierre-Louis Tharaux

  60. Cell‐derived microparticles and sickle cell disease chronic vasculopathy in sub‐Saharan Africa: A multinational study

    Article • British Journal of Haematology, November 2020, Wiley

    MD, PhD Pierre-Louis Tharaux

  61. Rôle pathogénique de l’expression anormale de la tétraspanine CD9 par les cellules épithéliales pariétales dans les glomérulopathies extracapillaires

    Article • médecine/sciences, October 2020, EDP Sciences

    MD, PhD Pierre-Louis Tharaux

  62. Nuclear receptors in podocyte biology and glomerular disease

    Article • Nature Reviews Nephrology, September 2020, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  63. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

    Article • Science, July 2020, American Association for the Advancement of Science

    MD, PhD Pierre-Louis Tharaux

  64. Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells

    Article • Journal of the American Society of Nephrology, July 2020, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  65. Deletion of the myeloid endothelin-B receptor confers long-term protection from angiotensin II-mediated kidney, eye and vessel injury.

    Article • Kidney International, June 2020, Elsevier

    MD, PhD Pierre-Louis Tharaux

  66. Metabolomic Profiling of Plasma and Erythrocytes in Sickle Mice Points to Altered Nociceptive Pathways

    Article • Cells, May 2020, MDPI AG

    MD, PhD Pierre-Louis Tharaux

  67. Parietal epithelial cells role in repair versus scarring after glomerular injury

    Article • Current Opinion in Nephrology & Hypertension, May 2020, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  68. Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

    Article • April 2020, Cold Spring Harbor Laboratory Press

    MD, PhD Pierre-Louis Tharaux

  69. The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

    Article • Haematologica, March 2020, Ferrata Storti Foundation (Haematologica)

    MD, PhD Pierre-Louis Tharaux

  70. Histamine provides an original vista on cardiorenal syndrome

    Article • Proceedings of the National Academy of Sciences, March 2020, Proceedings of the National Academy of Sciences

    MD, PhD Pierre-Louis Tharaux

  71. Podocytes maintain high basal levels of autophagy independent of mtor signaling

    Article • Autophagy, December 2019, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux

  72. L’hypertension artérielle maligne , un futur prometteur

    Article • La Presse Médicale, December 2019, Elsevier

    MD, PhD Pierre-Louis Tharaux

  73. CELL-Derived Microparticles and Sickle CELL Disease Chronic Vasculopathy in Sub-Saharan Africa

    Article • Blood, November 2019, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  74. Studying the Determinant of Sickle Cell Disease Vasculopathy in Sub-Saharan Africa : The Biocadre Study

    Article • Blood, November 2019, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  75. Cellular regeneration of podocytes from parietal cells: the debate is still open

    Article • Kidney International, September 2019, Elsevier

    MD, PhD Pierre-Louis Tharaux

  76. Uncovering the crucial pathogenic role of parietal epithelial cells in severe kidney diseases.

    Article • Nature Communications, July 2019, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  77. Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing

    Article • Blood Advances, June 2019, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  78. Posttranslational modifications of sickle hemoglobin in microparticles may promote injury

    Article • Kidney International, June 2019, Elsevier

    MD, PhD Pierre-Louis Tharaux

  79. Local miscommunications between glomerular cells as potential therapeutic targets for crescentic glomerulonephritides

    Article • Néphrologie & Thérapeutique, April 2019, Elsevier

    MD, PhD Pierre-Louis Tharaux

  80. A novel role for myeloid endothelin-B receptors in hypertension

    Article • European Heart Journal, January 2019, Oxford University Press (OUP)

    MD, PhD Pierre-Louis Tharaux

  81. Immunofluorescence Staining of WT-1/Podocalyxin on Mouse Kidney Sections

    Article • BIO-PROTOCOL, January 2019, Bio-Protocol, LLC

    MD, PhD Pierre-Louis Tharaux

  82. Imatinib Protects Against Hypoxia/Reoxygenation Induced Lung and Kidney Injury in a Humanized Mouse Model for SCD

    Article • Blood, November 2018, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  83. Proteomic Landscape of Neutrophils in Sickle Cell Anemia: An Unexpected Autoimmune Profile

    Article • Blood, November 2018, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  84. Resolution of sickle cell disease associated inflammation and tissue damage with 17R-Resolvin D1

    Article • Blood, November 2018, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  85. L’inhibition du récepteur de l’EGF sur les cellules immunitaires réduit l’athérosclérose expérimentale

    Article • médecine/sciences, June 2018, EDP Sciences

    MD, PhD Pierre-Louis Tharaux

  86. Selective EGF-Receptor Inhibition in CD4+ T Cells Induces Anergy and Limits Atherosclerosis

    Article • Journal of the American College of Cardiology, January 2018, Elsevier

    MD, PhD Pierre-Louis Tharaux

  87. Selective EGFR (Epidermal Growth Factor Receptor) Deletion in Myeloid Cells Limits Atherosclerosis—Brief Report

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 2018, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  88. Endothelial autophagy as a key mechanism in arterial diseases

    Article • Artery Research, December 2017, Elsevier

    MD, PhD Pierre-Louis Tharaux

  89. Cell cycle unlocking by a microRNA contributes to rapid kidney demolition in autoimmune diseases.

    Article • Nature Communications, November 2017, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  90. EndothelialEpas1Deficiency Is Sufficient To Promote Parietal Epithelial Cell Activation and FSGS in Experimental Hypertension

    Article • Journal of the American Society of Nephrology, September 2017, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  91. Endothelium-Neutrophil Communication via B1-Kinin Receptor–Bearing Microvesicles in Vasculitis

    Article • Journal of the American Society of Nephrology, July 2017, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  92. Targeting white blood cells: opportunities for new therapeutics for Sickle Cell Disease.

    Article • Haematologica, April 2017, Ferrata Storti Foundation (Haematologica)

    MD, PhD Pierre-Louis Tharaux

  93. Targeting mTOR Signaling Can Prevent the Progression of FSGS

    Article • Journal of the American Society of Nephrology, March 2017, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  94. Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism

    Article • Theranostics, January 2017, Ivyspring International Publisher

    MD, PhD Pierre-Louis Tharaux

  95. Hmox1Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries

    Article • Journal of Diabetes Research, January 2017, Hindawi Publishing Corporation

    MD, PhD Pierre-Louis Tharaux

  96. Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1

    Article • Journal of Biological Chemistry, December 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    MD, PhD Pierre-Louis Tharaux

  97. The Endothelin Receptor Etb Plays a Crucial Role for Recruitment of Neutrophils to the Vascular Wall in Sickle Cell Disease

    Article • Blood, December 2016, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  98. Sildenafil Prevents Podocyte InjuryviaPPAR-γ–Mediated TRPC6 Inhibition

    Article • Journal of the American Society of Nephrology, November 2016, American Society of Nephrology

    Tom Nijenhuis, MD, PhD Pierre-Louis Tharaux

  99. Autophagy in kidney disease and aging: lessons from rodent models

    Article • Kidney International, November 2016, Elsevier

    MD, PhD Pierre-Louis Tharaux

  100. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic ShockNovelty and Significance

    Article • Circulation Research, August 2016, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  101. Erratum: Erratum: Efficient second-harmonic imaging of collagen in histological slides using Bessel beam excitation

    Article • Scientific Reports, August 2016, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  102. Efficient second-harmonic imaging of collagen in histological slides using Bessel beam excitation

    Article • Scientific Reports, July 2016, Nature

    MD, PhD Pierre-Louis Tharaux

  103. Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage

    Article • Journal of the American Society of Nephrology, July 2016, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  104. Identification of the Single Immunodominant Region of the Native Human CC Chemokine Receptor 6 Recognized by Mouse Monoclonal Antibodies

    Article • PLOS One, June 2016, PLOS

    MD, PhD Pierre-Louis Tharaux

  105. French Intensive Care Society, International congress – Réanimation 2016

    Article • Annals of Intensive Care, June 2016, Springer Science + Business Media

    Professor Mabrouk Bahloul, MD, PhD Pierre-Louis Tharaux, Professor Eric DECONINCK

  106. Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx

    Article • Journal of the American Society of Nephrology, March 2016, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  107. How Is Proteinuric Diabetic Nephropathy Caused by Disturbed Proteostasis and Autophagy in Podocytes?

    Article • Diabetes, February 2016, American Diabetes Association

    MD, PhD Pierre-Louis Tharaux

  108. Delayed Healing of Sickle Cell Ulcers Is due to Impaired Angiogenesis and CXCL12 Secretion in Skin Wounds

    Article • Journal of Investigative Dermatology, February 2016, Elsevier

    Dany Nassar, MD, PhD Pierre-Louis Tharaux

  109. A Novel Extrinsic Pathway for the Unfolded Protein Response in the Kidney

    Article • Journal of the American Society of Nephrology, January 2016, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  110. Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury

    Article • Journal of the American Society of Nephrology, July 2015, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  111. Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response

    Article • PLOS One, June 2015, PLOS

    MD, PhD Pierre-Louis Tharaux

  112. Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

    Article • Autophagy, June 2015, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux

  113. Nuclear Factor Erythroid 2-Related Factor 2 Drives Podocyte-Specific Expression of Peroxisome Proliferator-Activated Receptor   Essential for Resistance to Crescentic GN

    Article • Journal of the American Society of Nephrology, May 2015, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  114. Correction to Multifunctional Rare-Earth Vanadate Nanoparticles: Luminescent Labels, Oxidant Sensors, and MRI Contrast Agents

    Article • ACS Nano, April 2015, American Chemical Society (ACS)

    MD, PhD Pierre-Louis Tharaux

  115. Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

    Article • Blood, March 2015, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  116. ROS Detection and Quantification with Lanthanide-Based Nanosensors

    Article • Biophysical Journal, January 2015, Elsevier

    MD, PhD Pierre-Louis Tharaux

  117. Multifunctional Rare-Earth Vanadate Nanoparticles: Luminescent Labels, Oxidant Sensors, and MRI Contrast Agents

    Article • ACS Nano, November 2014, American Chemical Society (ACS)

    MD, PhD Pierre-Louis Tharaux

  118. Early renal damage in patients with sickle cell disease in sub-Saharan Africa: a multinational, prospective, cross-sectional study

    Article • The Lancet Haematology, November 2014, Elsevier

    MD, PhD Pierre-Louis Tharaux

  119. Genetic Background–Dependent Thrombotic Microangiopathy Is Related to Vascular Endothelial Growth Factor Receptor 2 Signaling during Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

    Article • American Journal Of Pathology, September 2014, Elsevier

    MD, PhD Pierre-Louis Tharaux

  120. Update on crescentic glomerulonephritis

    Article • Seminars in Immunopathology, June 2014, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  121. Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice

    Article • Kidney International, May 2014, Elsevier

    MD, PhD Pierre-Louis Tharaux

  122. Regulation of the ROS Response Dynamics and Organization to PDGF Motile Stimuli Revealed by Single Nanoparticle Imaging

    Article • Chemistry & Biology, May 2014, Elsevier

    MD, PhD Pierre-Louis Tharaux

  123. Direct Action of Endothelin-1 on Podocytes Promotes Diabetic Glomerulosclerosis

    Article • Journal of the American Society of Nephrology, April 2014, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  124. Atteintes rénales au cours de la drépanocytose

    Article • Néphrologie & Thérapeutique, February 2014, Elsevier

    MD, PhD Pierre-Louis Tharaux

  125. The role of endothelin in glomerular diseases: Cellular culprits, cellular targets

    Article • Life Sciences, December 2013, Elsevier

    MD, PhD Pierre-Louis Tharaux

  126. ET-B receptors in podocytes promote diabetic glomerulosclerosis with β-catenin and NFκB activation

    Article • Life Sciences, December 2013, Elsevier

    MD, PhD Pierre-Louis Tharaux

  127. A pM inhibitor of HB-EGF derived from diphtheria toxin for the treatment of HB-EGF-related diseases

    Article • Toxicon, December 2013, Elsevier

    MD, PhD Pierre-Louis Tharaux

  128. Sickle Cell Disease Glomerulopathy In Five Subsaharian African Countries: Results Of The Cadre Study

    Article • Blood, November 2013, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  129. Transplantation rénale chez deux frères jumeaux monozygotes porteurs d’un polymorphisme G1/G2 de APOL1

    Article • Néphrologie & Thérapeutique, November 2013, Elsevier

    MD, PhD Pierre-Louis Tharaux

  130. Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression

    Article • Journal of Clinical Investigation, September 2013, American Society for Clinical Investigation

    MD, PhD Pierre-Louis Tharaux

  131. L22. Crescent formation: Unraveling local mediators that break glomerular epithelial cell tolerance to immune injury

    Article • La Presse Médicale, April 2013, Elsevier

    MD, PhD Pierre-Louis Tharaux

  132. Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, October 2012, Elsevier

    MD, PhD Pierre-Louis Tharaux

  133. Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease

    Article • Blood, September 2012, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  134. Analysis of Uncoupling Protein 2-Deficient Mice upon Anaesthesia and Sedation Revealed a Role for UCP2 in Locomotion

    Article • PLOS One, August 2012, PLOS

    MD, PhD Pierre-Louis Tharaux

  135. 22. Engineering of an HB-EGF Inhibitor from the Diphtheria Toxin Receptor–Binding Domain for the Treatment of HB-EGF-Related Diseases

    Article • Toxicon, August 2012, Elsevier

    MD, PhD Pierre-Louis Tharaux

  136. How Many Ways Can a Podocyte Die?

    Article • Seminars in Nephrology, July 2012, Elsevier

    MD, PhD Pierre-Louis Tharaux

  137. Targeting signaling pathways in glomerular diseases

    Article • Current Opinion in Nephrology & Hypertension, July 2012, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  138. Epidermal growth factor: a new therapeutic target in glomerular disease

    Article • Nephrology Dialysis Transplantation, March 2012, Oxford University Press (OUP)

    MD, PhD Pierre-Louis Tharaux

  139. Endothelin and the podocyte

    Article • Clinical Kidney Journal, February 2012, Oxford University Press (OUP)

    MD, PhD Pierre-Louis Tharaux

  140. Red Blood Cell Sickling During Oxygen Cycles in a Microdroplet Device

    Article • Biophysical Journal, January 2012, Elsevier

    MD, PhD Pierre-Louis Tharaux

  141. Erratum: Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

    Article • Nature Medicine, November 2011, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  142. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

    Article • Nature Medicine, September 2011, Nature

    MD, PhD Pierre-Louis Tharaux

  143. Red Blood Cell Sickling in Microdroplet Arrays

    Article • Biophysical Journal, February 2011, Elsevier

    MD, PhD Pierre-Louis Tharaux

  144. Endothelin in Renal Injury due to Sickle Cell Disease

    Article • January 2011, Karger Publishers

    MD, PhD Pierre-Louis Tharaux

  145. Endothelin and Podocyte Injury in Chronic Kidney Disease

    Article • January 2011, Karger Publishers

    MD, PhD Pierre-Louis Tharaux

  146. Response to Angiotensin II Type 1a–Deficient Bone Marrow–Derived Dendritic Cells Produce Higher Levels of Monocyte Chemoattractant Protein 1

    Article • Hypertension, July 2010, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  147. Corrigendum

    Article • AJP Renal Physiology, May 2010, American Physiological Society

    MD, PhD Pierre-Louis Tharaux

  148. Extracellular matrix alterations in hypertensive vascular remodeling

    Article • Journal of Molecular and Cellular Cardiology, March 2010, Elsevier

    MD, PhD Pierre-Louis Tharaux

  149. Glomerular Hyperfiltration in Adult Sickle Cell Anemia: A Frequent Hemolysis Associated Feature

    Article • Clinical Journal of the American Society of Nephrology, February 2010, American Society of Nephrology

    MD, PhD Pierre-Louis Tharaux

  150. TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice

    Article • Journal of Clinical Investigation, February 2010, American Society for Clinical Investigation

    MD, PhD Pierre-Louis Tharaux, Professor Jason Johnson

  151. Sickling of red blood cells through rapid oxygen exchange in microfluidic drops

    Article • Lab on a Chip, January 2010, Royal Society of Chemistry

    MD, PhD Pierre-Louis Tharaux

  152. A Role for Angiotensin II Type 1 Receptors on Bone Marrow-Derived Cells in the Pathogenesis of Angiotensin II–Dependent Hypertension

    Article • Hypertension, January 2010, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux, Prof. Dr. Johannes Stegbauer

  153. Measurement of the quadratic hyperpolarizability of the collagen triple helix and application to second harmonic imaging of natural and biomimetic collagenous tissues

    Article • September 2009, SPIE

    Dr Mathias Strupler, MD, PhD Pierre-Louis Tharaux

  154. Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells

    Article • Nature Nanotechnology, August 2009, Nature

    MD, PhD Pierre-Louis Tharaux

  155. Intracellular detection of Reactive Oxygen Species using single lanthanide nanoparticle imaging: application to vascular signaling

    Article • Biophysical Journal, February 2009, Elsevier

    MD, PhD Pierre-Louis Tharaux

  156. Efficacy of the endothelin receptor blocker bosentan for refractory sickle cell leg ulcers

    Article • British Journal of Haematology, September 2008, Wiley

    MD, PhD Pierre-Louis Tharaux

  157. Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension

    Article • AJP Renal Physiology, August 2008, American Physiological Society

    MD, PhD Pierre-Louis Tharaux

  158. Ultrasound Imaging of Renal Vaso-Occlusive Events in Transgenic Sickle Mice Exposed to Hypoxic Stress

    Article • Ultrasound in Medicine & Biology, July 2008, Elsevier

    MD, PhD Pierre-Louis Tharaux

  159. Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease

    Article • Journal of Clinical Investigation, May 2008, American Society for Clinical Investigation

    MD, PhD Pierre-Louis Tharaux

  160. Second harmonic microscopy to quantify renal interstitial fibrosis and arterial remodeling

    Article • Journal of Biomedical Optics, January 2008, SPIE

    Dr Mathias Strupler, MD, PhD Pierre-Louis Tharaux

  161. Variation in natriuretic peptides and mitral flow indexes during successful ventilatory weaning: a preliminary study

    Article • Intensive Care Medicine, April 2007, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  162. Second harmonic imaging and scoring of collagen in fibrotic tissues

    Article • Optics Express, April 2007, Optical Society of America (OSA)

    Dr Mathias Strupler, MD, PhD Pierre-Louis Tharaux

  163. Nonlinear microscopy of collagen fibers

    Article • February 2007, SPIE

    Dr Mathias Strupler, MD, PhD Pierre-Louis Tharaux

  164. Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells

    Article • Journal of Biological Chemistry, December 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    MD, PhD Pierre-Louis Tharaux

  165. The Dual Endothelin Receptor Antagonist Bosentan Prevents the Acute Sickle Cell-Related Hypoxic Lung and Kidney Injury in Transgenic SAD Mice.

    Article • Blood, November 2006, American Society of Hematology

    MD, PhD Pierre-Louis Tharaux

  166. Nouvelle approche des fibroses par microscopie multiphotonique avec génération de second harmonique

    Article • médecine/sciences, October 2006, EDP Sciences

    Dr Mathias Strupler, MD, PhD Pierre-Louis Tharaux

  167. Heparin binding EGF is necessary for vasospastic response to endothelin

    Article • The FASEB Journal, September 2006, Federation of American Societies For Experimental Biology (FASEB)

    MD, PhD Pierre-Louis Tharaux

  168. Transforming Growth Factor-α Mediates Nuclear Factor κB Activation in Strained Arteries

    Article • Circulation Research, August 2006, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  169. Urinary endothelin-1 as a marker of renal damage in sickle cell disease

    Article • Nephrology Dialysis Transplantation, September 2005, Oxford University Press (OUP)

    MD, PhD Pierre-Louis Tharaux

  170. EGF receptor activated by HB-EGF is required to calcium influx and vasoconstriction induced by endothelin-1

    Article • Journal of Hypertension, August 2005, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  171. UCP-2 does not modulate angiotensin II-induced high blood pressure but limits the development of hypertensive renal sclerosis

    Article • Journal of Hypertension, August 2005, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  172. Exploring type I angiotensin (AT1) receptor functions through gene targeting

    Article • Acta Physiologica Scandinavica, August 2004, Wiley

    MD, PhD Pierre-Louis Tharaux

  173. Progression and regression in renal vascular and glomerular fibrosis

    Article • International Journal of Experimental Pathology, April 2004, Wiley

    MD, PhD Pierre-Louis Tharaux

  174. Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition

    Article • The FASEB Journal, March 2004, Federation of American Societies For Experimental Biology (FASEB)

    MD, PhD Pierre-Louis Tharaux

  175. Troponin T as a marker of differentiation revealed by proteomic analysis in renal arterioles

    Article • The FASEB Journal, January 2004, Federation of American Societies For Experimental Biology (FASEB)

    MD, PhD Pierre-Louis Tharaux

  176. Analyse protéomique des protéines impliquées dans le phénotype rénal en hypertension rénovasculaire

    Article • Therapies, January 2004, Elsevier

    MD, PhD Pierre-Louis Tharaux

  177. Rho Kinase Promotes Alloimmune Responses by Regulating the Proliferation and Structure of T Cells

    Article • The Journal of Immunology, July 2003, The American Association of Immunologists

    MD, PhD Pierre-Louis Tharaux

  178. Epidermal growth factor receptor transactivation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice

    Article • The FASEB Journal, December 2002, Wiley

    MD, PhD Pierre-Louis Tharaux

  179. Cutaneous microvascular blood flow and reactivity in patients with homozygous sickle cell anaemia

    Article • European Journal Of Haematology, June 2002, Wiley

    MD, PhD Pierre-Louis Tharaux

  180. Renal and vascular effects of S21402, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase, in healthy subjects with hypovolemia*

    Article • Clinical Pharmacology & Therapeutics, June 2002, Nature

    MD, PhD Pierre-Louis Tharaux

  181. Regression of Renal Vascular Fibrosis by Endothelin Receptor Antagonism

    Article • Hypertension, February 2001, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  182. Transgenic Mice as a Tool to Study the Renin-Angiotensin System

    Article • January 2001, Karger Publishers

    MD, PhD Pierre-Louis Tharaux

  183. Angiotensin II Activates Collagen I Gene Through a Mechanism Involving the MAP/ER Kinase Pathway

    Article • Hypertension, September 2000, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  184. Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic Mice During Inhibition of Nitric Oxide Synthesis : Evidence for an Endothelin-Mediated Mechanism

    Article • Circulation, November 1999, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  185. Vascular Endothelin-1 Gene Expression and Synthesis and Effect on Renal Type I Collagen Synthesis and Nephroangiosclerosis During Nitric Oxide Synthase Inhibition in Rats

    Article • Circulation, April 1999, Wolters Kluwer Health

    MD, PhD Pierre-Louis Tharaux

  186. Activation of renin synthesis is dependent on intact nitric oxide production

    Article • Kidney International, June 1997, Elsevier

    MD, PhD Pierre-Louis Tharaux

  187. Role of αv integrins in mesangial cell adhesion to vitronectin and von Willebrand factor

    Article • Kidney International, June 1997, Elsevier

    MD, PhD Pierre-Louis Tharaux

  188. EGF and TGF-beta regulate neutral endopeptidase expression in renal vascular smooth muscle cells

    Article • AJP Cell Physiology, June 1997, American Physiological Society

    MD, PhD Pierre-Louis Tharaux

  189. Interest and limits of in vitro studies in renal vascular endocrinology

    Article • Cell Biology and Toxicology, December 1996, Springer Science + Business Media

    MD, PhD Pierre-Louis Tharaux

  190. Plasma Atrial and Brain Natriuretic Peptides in Mitral Stenosis Treated by Valvulotomy

    Article • Clinical Science, December 1994, Portland Press Ltd.

    MD, PhD Pierre-Louis Tharaux