All Stories

  1. Pharmacologic Inhibition of Vacuolar H+ATPase Attenuates Features of Severe Asthma in Mice

    Article • American Journal of Respiratory Cell and Molecular Biology, January 2020, American Thoracic Society

    Dr Pawan Sharma

  2. Altered Calcium in Ciliary Dysfunction: Potential Role of Endoplasmic Reticulum Stress and Ciliophagy

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2019, American Thoracic Society

    Dr Pawan Sharma

  3. Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition

    Article • European Journal of Pharmacology, November 2019, Elsevier

    Dr Pawan Sharma

  4. Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD

    Article • European Respiratory Journal, October 2019, European Respiratory Society (ERS)

    Dr Sukhwinder Singh Sohal, Dr Pawan Sharma

  5. Inhaled corticosteroids attenuate epithelial mesenchymal transition: implications for COPD and lung cancer prophylaxis

    Article • European Respiratory Journal, July 2019, European Respiratory Society (ERS)

    Dr Sukhwinder Singh Sohal, Dr Pawan Sharma

  6. Epithelial–mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics

    Article • International Journal of Chronic Obstructive Pulmonary Disease, July 2019, Dove Medical Press

    Mathew Eapen, Dr Pawan Sharma, Phil Hansbro, Archana Gaikwad

  7. There can be smoke without fire: warranted caution in promoting electronic cigarettes and heat not burn devices as a safer alternative to cigarette smoking

    Article • ERJ Open Research, July 2019, European Respiratory Society (ERS)

    Dr Pawan Sharma

  8. New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways

    Article • Clinical Science, July 2019, Portland Press Ltd.

    Dr Pawan Sharma

  9. Autophagy, a potential new target in asthma

    Article • American Journal of Respiratory Cell and Molecular Biology, May 2019, American Thoracic Society

    Dr Pawan Sharma, Dr Sukhwinder Singh Sohal

  10. The effectiveness of immunosuppressive cyclosporin in attenuating the progression of interstitial lung diseases

    Article • Journal of Thoracic Disease, May 2019, AME Publishing Company

    Dr Pawan Sharma

  11. IOQS (heat not burn) negatively impacts lung health.

    Article • ERJ Open Research, February 2019, European Respiratory Society (ERS)

    Dr Pawan Sharma

  12. Impact of Maternal Air Pollution Exposure on Children’s Lung Health: An Indian Perspective

    Article • Toxics, November 2018, MDPI AG

    Dr Pawan Sharma

  13. Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities

    Article • Drugs, November 2018, Springer Science + Business Media

    Dr Pawan Sharma

  14. Dysfunctional Immunity and Microbial Adhesion Molecules in Smoking-Induced Pneumonia

    Article • American Journal of Respiratory and Critical Care Medicine, October 2018, American Thoracic Society

    Dr Pawan Sharma

  15. Steroid insensitive fixed airflow obstruction is not related to airway inflammation in older non-smokers with asthma

    Article • September 2018, Springer Science + Business Media

    Dr Pawan Sharma

  16. Impact of Maternal Air Pollution Exposure on Children’s Lung Health: An Indian Perspective

    Article • September 2018, MDPI AG

    Dr Pawan Sharma

  17. Impact of Maternal Air Pollution Exposure on Children’s Lung Health: An Indian Perspective

    Article • August 2018, MDPI AG

    Dr Pawan Sharma

  18. Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease

    Article • Clinical Science, July 2018, Portland Press Ltd.

    Dr Pawan Sharma

  19. sE-cadherin and sVE-cadherin indicate active epithelial/endothelial to mesenchymal transition (EMT and EndoMT) in smokers and COPD: implications for new biomarkers and therapeutics

    Article • Biomarkers, June 2018, Taylor & Francis

    Dr Pawan Sharma

  20. Autophagy and airway fibrosis: Is there a link?

    Article • F1000Research, June 2018, Faculty of 1000, Ltd.

    Dr Pawan Sharma

  21. Maternal E-Cigarette Exposure in Mice Alters DNA Methylation and Lung Cytokine Expression in Offspring

    Article • American Journal of Respiratory Cell and Molecular Biology, March 2018, American Thoracic Society

    Brian Oliver, Dr Pawan Sharma

  22. A circadian based inflammatory response – implications for respiratory disease and treatment

    Article • Sleep Science and Practice, September 2017, Springer Science + Business Media

    Dr Pawan Sharma

  23. Maternal eCigarette vaping enhances Th2 driven asthma in the offspring

    Article • September 2017, European Respiratory Society (ERS)

    Dr Pawan Sharma

  24. Effect of long-term maternal smoking on the offspring’s lung health

    Article • AJP Lung Cellular and Molecular Physiology, August 2017, American Physiological Society

    Dr Pawan Sharma, Brian Oliver

  25. Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells

    Article • AJP Lung Cellular and Molecular Physiology, July 2017, American Physiological Society

    Dr Pawan Sharma

  26. Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice

    Article • Scientific Reports, April 2017, Springer Science + Business Media

    Dr Pawan Sharma

  27. Autophagy and airway fibrosis: Is there a link?

    Article • F1000Research, April 2017, Faculty of 1000, Ltd.

    Dr Deepak Deshpande, Anudeep Kota, Brian Oliver, Dr Pawan Sharma, Mehra Haghi

  28. Targeting ASK1 in preventing airway smooth muscle growth: Implications for airway remodeling in COPD

    Article • European Respiratory Journal, September 2016, European Respiratory Society (ERS)

    Dr Pawan Sharma

  29. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells

    Article • AJP Lung Cellular and Molecular Physiology, February 2016, American Physiological Society

    Dr Pawan Sharma

  30. A role for transient receptor potential ankyrin 1 cation channel (TRPA1) in airway hyper-responsiveness?

    Article • Canadian Journal of Physiology and Pharmacology, March 2015, Canadian Science Publishing

    Dr Pawan Sharma

  31. Characterization of the dystrophin–glycoprotein complex in airway smooth muscle: role of δ-sarcoglycan in airway responsiveness 1

    Article • Canadian Journal of Physiology and Pharmacology, March 2015, Canadian Science Publishing

    Dr Pawan Sharma

  32. Mechanisms of glucocorticoid action and insensitivity in airways disease

    Article • Pulmonary Pharmacology & Therapeutics, December 2014, Elsevier

    Dr Pawan Sharma

  33. Role of Dystrophin in Airway Smooth Muscle Phenotype, Contraction and Lung Function

    Article • PLoS ONE, July 2014, PLOS

    Dr Pawan Sharma

  34. Airway mesenchymal cell death by mevalonate cascade inhibition: Integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, July 2014, Elsevier

    Dr Pawan Sharma

  35. Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

    Article • Pharmacology & Therapeutics, July 2014, Elsevier

    Dr Pawan Sharma

  36. Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary...

    Article • Molecular Pharmacology, February 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Pawan Sharma

  37. Models to study airway smooth muscle contraction in vivo, ex vivo and in vitro: Implications in understanding asthma

    Article • Pulmonary Pharmacology & Therapeutics, February 2013, Elsevier

    Dr Pawan Sharma

  38. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase

    Article • British Journal of Pharmacology, September 2012, Wiley

    Dr Pawan Sharma

  39. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts

    Article • Cell Death and Disease, June 2012, Springer Science + Business Media

    Dr Pawan Sharma

  40. Anti-Mitogenic Effects Of Bitter Taste Receptor (BTR) Agonists On Human Airway Smooth Muscle (ASM) Cells

    Article • May 2012, American Thoracic Society

    Dr Pawan Sharma

  41. Mevalonate Cascade Inhibition Induced Apoptosis, Autophagy, And ER-Stress In Airway Mesenchymal Cells: Regulatory Function Of Autophagy And Bcl2 Pro-Apoptotic Proteins

    Article • May 2012, American Thoracic Society

    Dr Pawan Sharma

  42. Reduction In Airway Smooth Muscle Contraction And Airway Narrowing By PDE4 Inhibitor Roflumilast Is Enhanced In Presence Of An Inhaled Corticosteroid

    Article • May 2012, American Thoracic Society

    Dr Pawan Sharma

  43. Phosphodiesterase 4 Inhibitors Enhance Glucocorticoid-Dependent Gene Transcription In Human Airway Epithelial Cells: A Mechanism For The Clinical Efficacy Of Roflumilast In Severe Chronic Obstructive Pulmonary Disease

    Article • May 2012, American Thoracic Society

    Dr Pawan Sharma

  44. Motility, Survival, and Proliferation

    Article • January 2012, Wiley

    Dr Pawan Sharma

  45. Airway Smooth Muscle Cells

    Article • July 2011, Wiley

    Dr Pawan Sharma

  46. Modifiers Of Camp Signaling Inhibit TGF-Beta1 Induced Fibrosis Through PKA Mediated Regulation Of The Map Kinase Pathway

    Article • May 2011, American Thoracic Society

    Dr Pawan Sharma

  47. Epithelium-Dependent Modulation Of Muscarinic Hyperresponsiveness Of Airways From Caveolin-1 Knockout Mice Is Mediated Through Cyclooxygenase-2

    Article • May 2011, American Thoracic Society

    Dr Pawan Sharma

  48. Autophagy Regulates Tgf-Beta1 Induced Fibrosis In Human Airway Smooth Muscle Cells

    Article • May 2011, American Thoracic Society

    Dr Pawan Sharma

  49. Glutamate Enhances Amphiregulin (AREG) Production from Human Airway Smooth Muscle Cells

    Article • Journal of Allergy and Clinical Immunology, February 2011, Elsevier

    Dr Pawan Sharma

  50. Mevalonate Cascade Regulation of Airway Mesenchymal Cell Autophagy and Apoptosis: A Dual Role for p53

    Article • PLoS ONE, January 2011, PLOS

    Dr Pawan Sharma

  51.  -Dystroglycan binds caveolin-1 in smooth muscle: a functional role in caveolae distribution and Ca2+ release

    Article • Journal of Cell Science, August 2010, The Company of Biologists

    Dr Pawan Sharma

  52. Dual Role For P53 In Simvastatin-Induced Cell Death In Airway Mesenchymal Cells

    Article • May 2010, American Thoracic Society

    Dr Pawan Sharma

  53. The Dystrophin Glycoprotein Complex (DGC) Regulates Spatial Organization And Function Of Caveolae In Human Airway Smooth Muscle Cells

    Article • May 2010, American Thoracic Society

    Dr Pawan Sharma

  54. Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, April 2010, Elsevier

    Dr Pawan Sharma

  55. S100A8/A9 as a Pro-inflammatory Cytokine in Obstructive Airway Disease Via the Multi-Ligand Receptor, RAGE

    Article • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, December 2009, Bentham Science Publishers

    Dr Pawan Sharma

  56. Airway smooth muscle in asthma: Phenotype plasticity and function

    Article • Pulmonary Pharmacology & Therapeutics, October 2009, Elsevier

    Dr Pawan Sharma

  57. Role of Dystrophin in Contractile Phenotype Expression and Ca2+Mobilization in Airway Smooth Muscle.

    Article • April 2009, American Thoracic Society

    Dr Pawan Sharma

  58. hTERT-Immortalized Human Airway Smooth Muscle Cells Retain a Multifunctional Phenotype.

    Article • April 2009, American Thoracic Society

    Dr Pawan Sharma

  59. β-Dystroglycan Interacts with Caveolin-1: Central Role in Intracellular Calcium Mobilization by Airway Smooth Muscle.

    Article • April 2009, American Thoracic Society

    Dr Pawan Sharma

  60. Pharmacology of a Novel, Orally Active PDE4 Inhibitor

    Article • Pharmacology, January 2009, Karger Publishers

    Dr Pawan Sharma, Dr. MAHESH KUMAR SETH

  61. Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor

    Article • Inflammation Research, March 2008, Springer Science + Business Media

    Dr Pawan Sharma

  62. Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation

    Article • AJP Lung Cellular and Molecular Physiology, January 2008, American Physiological Society

    Dr Pawan Sharma

  63. Insulin increases the expression of contractile phenotypic markers in airway smooth muscle

    Article • AJP Cell Physiology, July 2007, American Physiological Society

    Dr Pawan Sharma