All Stories

  1. Nanomolar concentrations of the photodynamic compound TLD-1433 effectively inactivate numerous human pathogenic viruses

    Article • Heliyon, June 2024, Elsevier

    Professor Kevin Coombs

  2. Identification of Thioredoxin1 interacting proteins in neuronal cytoskeletal organization during autophagy

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Professor Kevin Coombs

  3. Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication

    Article • Viruses, January 2024, MDPI AG

    Professor Kevin Coombs

  4. Procedures to grow and use mammalian orthoreoviruses

    Article • Current Protocols, April 2023, Wiley

    Professor Kevin Coombs

  5. PSMA2 knockdown impacts expression of proteins involved in immune and cellular stress responses in human lung cells

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2023, Elsevier

    Professor Kevin Coombs

  6. Infections of the Cerebellum

    Article • January 2023, Springer Science + Business Media

    Professor Kevin Coombs

  7. Knocking down some cellular genes (HLA-A, HSPA5, IGFBP5, PSMA2) increases ZIka virus growth

    Article • Viruses, December 2022, MDPI AG

    Professor Kevin Coombs

  8. Current understanding of the airborne transmission of important viral animal pathogens in spreading disease

    Article • Biosystems Engineering, December 2022, Elsevier

    Professor Kevin Coombs

  9. Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses

    Article • Frontiers in Microbiology, October 2022, Frontiers

    Professor Kevin Coombs

  10. Development and characterization of influenza M2 ectodomain and/or hemagglutinin stalk-based dendritic cell-targeting vaccines

    Article • Frontiers in Microbiology, August 2022, Frontiers

    Professor Kevin Coombs

  11. Influenza A Virus Uses PSMA2 for Downregulation of the NRF2-Mediated Oxidative Stress Response

    Article • Journal of Virology, March 2022, ASM Journals

    Professor Kevin Coombs

  12. Zika Virus Infection of Sertoli Cells Alters Protein Expression Involved in Activated Immune and Antiviral Response Pathways, Carbohydrate Metabolism and Cardiovascular Disease

    Article • Viruses, February 2022, MDPI AG

    Professor Kevin Coombs

  13. Development and characterization of influenza M2 ectodomain and/or HA stalk-based DC-targeting vaccines for different influenza infections

    Article • October 2021, Cold Spring Harbor Laboratory Press

    Professor Kevin Coombs

  14. Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Professor Kevin Coombs

  15. Dose–response modelling of infectious animal diseases coupled with computational fluid dynamics: A simulation of airborne porcine reproductive and respiratory syndrome virus

    Article • Biosystems Engineering, August 2021, Elsevier

    Professor Kevin Coombs

  16. Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other Coronaviruses

    Article • International Journal of Molecular Sciences, June 2021, MDPI AG

    Professor Kevin Coombs

  17. A Single Point Mutation, Asn16→Lys, Dictates the Temperature-Sensitivity of the Reovirus tsG453 Mutant

    Article • Viruses, February 2021, MDPI AG

    Professor Kevin Coombs

  18. Embryonic Origins of Virus-Induced Hearing Loss: Overview of Molecular Etiology

    Article • Viruses, January 2021, MDPI AG

    Professor Kevin Coombs

  19. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    Article • Autophagy, January 2021, Taylor & Francis

    MD, PhD Pierre-Louis Tharaux, Joilson O. Martins, Dr. rer. nat. Marc Herb, Dr Marcia R Cominetti, Alessio Di Fonzo, Christoph Gerhardt, Dr Mustafa Sahin, Dr Cinzia Volonté, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Prof Robert Bryson-Richardson, Professor Hyun Kyu Song, Prof Claudia Cavadas, Professor Po Sing Leung, Paula Ludovico, Javeed Shah, Giovanni Di Guardo, Dr Takeshi Noda, Professor Tullio Florio, Professor Kevin Coombs, Ning Chen, Maria Vaccaro

  20. Identification of cellular proteins dysregulated by Zika virus infection

    Article • January 2021, Elsevier

    Professor Kevin Coombs

  21. Update on Proteomic approaches to uncovering virus-induced protein alterations and virus –host protein interactions during the progression of viral infection

    Article • Expert Review of Proteomics, August 2020, Taylor & Francis

    Professor Kevin Coombs

  22. Zika Infection Disrupts Proteins Involved in the Neurosensory System

    Article • Frontiers in Cell and Developmental Biology, July 2020, Frontiers

    Professor Kevin Coombs

  23. ZIKV Infection Induces DNA Damage Response and Alters the Proteome of Gastrointestinal Cells

    Article • Viruses, July 2020, MDPI AG

    Professor Kevin Coombs

  24. Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions

    Article • PLoS Neglected Tropical Diseases, June 2020, PLOS

    Professor Kevin Coombs

  25. Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome

    Article • Cells, March 2020, MDPI AG

    Professor Kevin Coombs

  26. Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses

    Article • Viruses, November 2019, MDPI AG

    Professor Kevin Coombs

  27. Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner

    Article • Science Translational Medicine, September 2019, American Association for the Advancement of Science

    Professor Kevin Coombs

  28. Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells

    Article • Cell Death and Disease, April 2019, Springer Science + Business Media

    Professor Kevin Coombs

  29. Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance

    Article • Frontiers in Microbiology, March 2019, Frontiers

    Professor Kevin Coombs

  30. Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies

    Article • Viruses, March 2019, MDPI AG

    Professor Kevin Coombs

  31. Vero Cell Proteomic Changes Induced by Zika Virus Infection

    Article • PROTEOMICS, January 2019, Wiley

    Professor Kevin Coombs

  32. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

    Article • Virulence, January 2019, Taylor & Francis

    Dr Parvaneh Mehrbod, Mohammad Hashemi, Professor Kevin Coombs, Saeid Ghavami, Hadis Malek

  33. The Effectiveness of Air Ionization in Reducing Bioaerosols and Airborne PRRS Virus in a Ventilated Space

    Article • Transactions of the ASABE, January 2019, American Society of Agricultural and Biological Engineers (ASABE)

    Professor Kevin Coombs

  34. Global Interactomics Connect Nuclear Mitotic Apparatus Protein NUMA1 to Influenza Virus Maturation

    Article • Viruses, December 2018, MDPI AG

    Professor Kevin Coombs

  35. Serum‐reduced media impacts on cell viability and protein expression in human lung epithelial cells

    Article • Journal of Cellular Physiology, December 2018, Wiley

    Professor Kevin Coombs

  36. Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus

    Article • EBioMedicine, June 2018, Elsevier

    Professor Kevin Coombs

  37. Methods and approaches to disease mechanisms using systems kinomics

    Article • Synthetic and Systems Biotechnology, March 2018, Elsevier

    Professor Kevin Coombs

  38. Autophagy activation is required for influenza A virus-induced apoptosis and replication

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, February 2018, Elsevier

    Professor Kevin Coombs

  39. Viruses Produced From Cells

    Article • January 2017, Elsevier

    Professor Kevin Coombs

  40. Infections of the Cerebellum

    Article • January 2017, Springer Science + Business Media

    Professor Kevin Coombs

  41. New use of an old drug: chloroquine reduces viral and ALT levels in HCV non-responders (a randomized, triple-blind, placebo-controlled pilot trial)

    Article • Canadian Journal of Physiology and Pharmacology, June 2016, Canadian Science Publishing

    Saeid Ghavami, Kamran Lankarani, Professor Kevin Coombs

  42. Avian influenza viruses that cause highly virulent infections in humans exhibit distinct replicative properties in contrast to human H1N1 viruses

    Article • Scientific Reports, April 2016, Springer Science + Business Media

    Professor Kevin Coombs

  43. Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis

    Article • Expert Reviews in Molecular Medicine, January 2016, Cambridge University Press

    Saeid Ghavami, Professor Kevin Coombs

  44. Highly Pathogenic H5N1 and Novel H7N9 Influenza A Viruses Induce More Profound Proteomic Host Responses than Seasonal and Pandemic H1N1 Strains

    Article • Journal of Proteome Research, October 2015, American Chemical Society (ACS)

    Professor Kevin Coombs

  45. Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion

    Article • Journal of Virology, September 2015, ASM Journals

    Professor Kevin Coombs

  46. Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways

    Article • PROTEOMICS, May 2015, Wiley

    Professor Kevin Coombs

  47. Quantification of the Host Response Proteome after Herpes Simplex Virus Type 1 Infection

    Article • Journal of Proteome Research, April 2015, American Chemical Society (ACS)

    Professor Kevin Coombs

  48. Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells

    Article • Frontiers in Cellular and Infection Microbiology, April 2015, Frontiers

    Professor Kevin Coombs

  49. Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1

    Article • AJP Lung Cellular and Molecular Physiology, February 2015, American Physiological Society

    Professor Kevin Coombs

  50. Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

    Article • World Journal of Gastroenterology, January 2015, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Kamran Lankarani, Professor Kevin Coombs

  51. Proteasomal Serine Hydrolases Are Up-Regulated by and Required for Influenza Virus Infection

    Article • Journal of Proteome Research, April 2014, American Chemical Society (ACS)

    Professor Kevin Coombs

  52. Reoviruses: Molecular Biology☆

    Article • January 2014, Elsevier

    Professor Kevin Coombs

  53. Knockdown of specific host factors protects against influenza virus-induced cell death

    Article • Cell Death and Disease, August 2013, Springer Science + Business Media

    Professor Kevin Coombs

  54. Influenza A Infection of Primary Human Airway Epithelial Cells Up-Regulates Proteins Related to Purine Metabolism and Ubiquitin-Related Signaling

    Article • Journal of Proteome Research, June 2013, American Chemical Society (ACS)

    Professor Kevin Coombs

  55. Generation and characterization of a new panel of broadly reactive anti-NS1 mAbs for detection of influenza A virus

    Article • Journal of General Virology, March 2013, Society for General Microbiology

    Professor Kevin Coombs

  56. Quantitative omics and its application to study virus-host interactions—a new frontier

    Article • Frontiers in Microbiology, January 2013, Frontiers

    Professor Kevin Coombs

  57. HeLa cell response proteome alterations induced by mammalian reovirus T3D infection

    Article • Virology Journal, January 2013, Springer Science + Business Media

    Professor Kevin Coombs

  58. Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection

    Article • PLoS ONE, December 2012, PLOS

    Professor Kevin Coombs

  59. Transcriptomics and quantitative proteomics in virology

    Article • Future Virology, December 2012, Future Medicine

    Professor Kevin Coombs

  60. Influenza Virus Induces Apoptosis via BAD-Mediated Mitochondrial Dysregulation

    Article • Journal of Virology, November 2012, ASM Journals

    Professor Kevin Coombs

  61. Response of Primary Human Airway Epithelial Cells to Influenza Infection: A Quantitative Proteomic Study

    Article • Journal of Proteome Research, July 2012, American Chemical Society (ACS)

    Professor Kevin Coombs

  62. Influenza A Virus Replication In A549 Human Epithelial Cells Requires Activation Of Autophagy Pathways

    Article • May 2012, American Thoracic Society

    Professor Kevin Coombs

  63. Medical Microbiology and Diagnosis in the “Omic” Era

    Article • Journal of Medical Microbiology & Diagnosis, January 2012, OMICS Publishing Group

    Professor Kevin Coombs

  64. Fishing Beyond the Peer: Future Omic Analyses of Virus-Host Interactions

    Article • Journal of Virology & Antiviral Research, January 2012, OMICS Publishing Group

    Professor Kevin Coombs

  65. Non-Biased Enrichment Does Not Improve Quantitative Proteomic Delineation of Reovirus T3D-Infected HeLa Cell Protein Alterations

    Article • Frontiers in Microbiology, January 2012, Frontiers

    Professor Kevin Coombs

  66. Activity based protein profiling to detect serine hydrolase alterations in virus infected cells

    Article • Frontiers in Microbiology, January 2012, Frontiers

    Professor Kevin Coombs

  67. Virus-triggered autophagy in viral hepatitis - possible novel strategies for drug development

    Article • Journal of Viral Hepatitis, October 2011, Wiley

    Professor Kevin Coombs

  68. Quantitative proteomics of complex mixtures

    Article • Expert Review of Proteomics, October 2011, Taylor & Francis

    Professor Kevin Coombs

  69. Reoviruses

    Article • February 2011, Wiley

    Professor Kevin Coombs

  70. Quantitative Proteomic Analyses of Influenza Virus-Infected Cultured Human Lung Cells

    Article • Journal of Virology, August 2010, ASM Journals

    Professor Kevin Coombs

  71. Conserved structure/function of the orthoreovirus major core proteins

    Article • Virus Research, September 2009, Elsevier

    Professor Kevin Coombs

  72. Avian Reoviruses: Propagation, Quantification, and Storage

    Article • Current Protocols in Microbiology, August 2009, Wiley

    Professor Kevin Coombs

  73. Growth and Maintenance of Quail Fibrosarcoma QM5 Cells

    Article • Current Protocols in Microbiology, August 2009, Wiley

    Professor Kevin Coombs

  74. Mammalian Reoviruses: Propagation, Quantification, and Storage

    Article • Current Protocols in Microbiology, August 2009, Wiley

    Professor Kevin Coombs

  75. Corrigendum to ‘Survival of enveloped and non-enveloped viruses on surfaces compared with other micro-organisms and impact of suboptimal disinfectant exposure [Journal of Hospital Infection 2008;69:368–376]’

    Article • Journal of Hospital Infection, March 2009, Elsevier

    Professor Kevin Coombs

  76. Survival of enveloped and non-enveloped viruses on surfaces compared with other micro-organisms and impact of suboptimal disinfectant exposure

    Article • Journal of Hospital Infection, August 2008, Elsevier

    Professor Kevin Coombs

  77. Characterization of a trypsin-dependent avian influenza H5N1-pseudotyped HIV vector system for high throughput screening of inhibitory molecules

    Article • Antiviral Research, July 2008, Elsevier

    Professor Kevin Coombs

  78. Assignment of avian reovirus temperature-sensitive mutant recombination groups E, F, and G to genome segments

    Article • Virology, June 2008, Elsevier

    Professor Kevin Coombs

  79. Reovirus Serotypes Elicit Distinctive Patterns of Recall Immunity in Humans

    Article • Journal of Virology, May 2008, ASM Journals

    Professor Kevin Coombs

  80. Conformational changes accompany activation of reovirus RNA-dependent RNA transcription

    Article • Journal of Structural Biology, May 2008, Elsevier

    Professor Kevin Coombs

  81. Avian reovirus L2 genome segment sequences and predicted structure/function of the encoded RNA-dependent RNA polymerase protein

    Article • Virology Journal, January 2008, Springer Science + Business Media

    Professor Kevin Coombs

  82. Genetic characterization of a new mammalian reovirus, type 2 Winnipeg (T2W)

    Article • Virus Genes, October 2006, Springer Science + Business Media

    Professor Kevin Coombs

  83. Reoviruses

    Article • April 2006, Wiley

    Professor Kevin Coombs

  84. Intracellular ATP and total adenylate concentrations are critical predictors of reovirus productivity from Vero cells

    Article • Biotechnology and Bioengineering, March 2006, Wiley

    Professor Kevin Coombs

  85. Sequences of avian reovirus M1, M2 and M3 genes and predicted structure/function of the encoded μ proteins

    Article • Virus Research, March 2006, Elsevier

    Professor Kevin Coombs

  86. High-resolution mass spectrometric mapping of reovirus digestion

    Article • Rapid Communications in Mass Spectrometry, January 2006, Wiley

    Professor Kevin Coombs

  87. Infectious entry of reovirus cores into mammalian cells enhanced by transfection

    Article • Journal of Virological Methods, September 2005, Elsevier

    Professor Kevin Coombs

  88. Assignment of avian reovirus temperature-sensitive mutant recombination groups B, C, and D to genome segments

    Article • Virology, August 2005, Elsevier

    Professor Kevin Coombs

  89. Enteric Virus Indicators: Reovirus Versus Poliovirus

    Article • Journal of Environmental Engineering, July 2005, American Society of Civil Engineers (ASCE)

    Professor Kevin Coombs

  90. Avian Reovirus Temperature-Sensitive Mutant tsA12 Has a Lesion in Major Core Protein σA and Is Defective in Assembly

    Article • Journal of Virology, October 2004, ASM Journals

    Professor Kevin Coombs

  91. Mycophenolic acid inhibits avian reovirus replication

    Article • Antiviral Research, October 2004, Elsevier

    Professor Kevin Coombs

  92. Inhibition of Reovirus by Mycophenolic Acid Is Associated with the M1 Genome Segment

    Article • Journal of Virology, June 2004, ASM Journals

    Professor Kevin Coombs

  93. REOVIRUS TYPE 2 ISOLATED FROM CEREBROSPINAL FLUID

    Article • The Pediatric Infectious Disease Journal, April 2004, Wolters Kluwer Health

    Professor Kevin Coombs

  94. Article • Virology Journal, January 2004, Springer Science + Business Media

    Professor Kevin Coombs

  95. Introduction to Virus Structure, Classification, Replication, and Hosts

    Article • August 2003, Taylor & Francis

    Professor Kevin Coombs

  96. Reoviruses

    Article • July 2003, Wiley

    Professor Kevin Coombs

  97. Digestion pattern of reovirus outer capsid protein σ3 determined by mass spectrometry

    Article • Virology, July 2003, Elsevier

    Professor Kevin Coombs

  98. Mammalian reovirus core protein µ2 initiates at the first start codon and is acetylated

    Article • Rapid Communications in Mass Spectrometry, November 2002, Wiley

    Professor Kevin Coombs

  99. Avian Reovirus Major μ-Class Outer Capsid Protein Influences Efficiency of Productive Macrophage Infection in a Virus Strain-Specific Manner

    Article • Journal of Virology, June 2001, ASM Journals

    Professor Kevin Coombs

  100. Generation and Genetic Characterization of Avian Reovirus Temperature-Sensitive Mutants

    Article • Virology, May 2001, Elsevier

    Professor Kevin Coombs

  101. Reovirus ςNS Protein Is Required for Nucleation of Viral Assembly Complexes and Formation of Viral Inclusions

    Article • Journal of Virology, February 2001, ASM Journals

    Professor Kevin Coombs

  102. Application of a Serum-Free Medium for the Growth of Vero Cells and the Production of Reovirus

    Article • Biotechnology Progress, October 2000, American Chemical Society (ACS)

    Professor Kevin Coombs

  103. A comparative analysis of Freon substitutes in the purification of reovirus and calicivirus

    Article • Journal of Virological Methods, October 2000, Elsevier

    Professor Kevin Coombs

  104. Production of reovirus type-1 and type-3 from Vero cells grown on solid and macroporous microcarriers

    Article • Biotechnology and Bioengineering, January 1999, Wiley

    Professor Kevin Coombs

  105. Absence of superinfection exclusion during asynchronous reovirus infections of mouse, monkey, and human cell lines

    Article • Virus Research, April 1998, Elsevier

    Professor Kevin Coombs

  106. Stoichiometry of Reovirus Structural Proteins in Virus, ISVP, and Core Particles

    Article • Virology, March 1998, Elsevier

    Professor Kevin Coombs

  107. Assembly of the reovirus outer capsid requires μ1/σ3 interactions which are prevented by misfolded σ3 protein in temperature-sensitive mutant tsG453

    Article • Virus Research, December 1996, Elsevier

    Professor Kevin Coombs

  108. Identification and characterization of a double-stranded RNA- reovirus temperature-sensitive mutant defective in minor core protein mu2

    Article • Journal of Virology, July 1996, ASM Journals

    Professor Kevin Coombs

  109. The Reovirus Mutant tsA279 Has Temperature-Sensitive Lesions in the M2 and L2 Genes: The M2 Gene Is Associated with Decreased Viral Protein Production and Blockade in Transmembrane Transport

    Article • Virology, February 1995, Elsevier

    Professor Kevin Coombs

  110. Crystallization of the reovirus type 3 dearing core crystal packing is determined by the λ2 protein

    Article • Journal of Molecular Biology, September 1990, Elsevier

    Professor Kevin Coombs

  111. Organization of the sindbis virus nucleocapsid as revealed by bifunctional cross-linking agents

    Article • Journal of Molecular Biology, May 1987, Elsevier

    Dr Dennis Taylor Brown, Professor Kevin Coombs

  112. Topological organization of Sindbis virus capsid protein in isolated nucleocapsids

    Article • Virus Research, April 1987, Elsevier

    Dr Dennis Taylor Brown, Professor Kevin Coombs

  113. Evidence for a change in capsid morphology during Sindbis virus envelopment

    Article • Virus Research, January 1984, Elsevier

    Dr Dennis Taylor Brown, Professor Kevin Coombs