All Stories

  1. MK2–TNF–Signaling Comes Full Circle

    Article • Trends in Biochemical Sciences, March 2018, Elsevier

    Matthias Gaestel, Manoj B Menon

  2. To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function

    Article • Molecular & Cellular Oncology, November 2017, Taylor & Francis

    Matthias Gaestel, Manoj B Menon

  3. Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells

    Article • Free Radical Biology and Medicine, December 2015, Elsevier

    Matthias Gaestel

  4. Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK

    Article • PLoS ONE, August 2015, PLOS

    Matthias Gaestel, Manoj B Menon

  5. Blockade of MK2 is protective in inflammation-associated colorectal cancer development

    Article • International Journal of Cancer, August 2015, Wiley

    Matthias Gaestel

  6. The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis

    Article • The Journal of Immunology, June 2015, The American Association of Immunologists

    Matthias Gaestel

  7. TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

    Article • Neuron, June 2015, Elsevier

    Matthias Gaestel

  8. Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression

    Article • PLoS ONE, May 2015, PLOS

    Matthias Gaestel

  9. Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations

    Article • PLoS ONE, May 2015, PLOS

    Matthias Gaestel

  10. Oncostatin M regulates SOCS3 mRNA stability via the MEK–ERK1/2-pathway independent of p38MAPK/MK2

    Article • Cellular Signalling, March 2015, Elsevier

    Matthias Gaestel

  11. The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

    Article • eLife, February 2015, eLife

    Matthias Gaestel

  12. Sep(t)arate or not - how some cells take septin-independent routes through cytokinesis

    Article • Journal of Cell Science, February 2015, The Company of Biologists

    Matthias Gaestel, Manoj B Menon

  13. Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries

    Article • Acta Physiologica, February 2015, Wiley

    Matthias Gaestel

  14. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

    Article • RNA, December 2014, Cold Spring Harbor Laboratory Press

    Matthias Gaestel, Manoj B Menon

  15. Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Deficiency Reduces Insulin Sensitivity in High-Fat Diet-Fed Mice

    Article • PLoS ONE, September 2014, PLOS

    Matthias Gaestel

  16. TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

    Article • Neuron, September 2014, Elsevier

    Matthias Gaestel

  17. The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility

    Article • Nature Communications, August 2014, Nature

    Matthias Gaestel

  18. Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury

    Article • Thrombosis and Haemostasis, August 2014, Schattauer GmbH

    Matthias Gaestel

  19. MK2 and Fas Receptor Contribute to the Severity of CNS Demyelination

    Article • PLoS ONE, June 2014, PLOS

    Matthias Gaestel

  20. Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration

    Article • Cardiovascular Research, June 2014, European Society of Cardiology

    Matthias Gaestel, Manoj B Menon

  21. MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection

    Article • The FASEB Journal, June 2014, Federation of American Societies For Experimental Biology (FASEB)

    Matthias Gaestel

  22. Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 Mediates Apoptosis during Lung Vascular Permeability by Regulating Movement of Cleaved Caspase 3

    Article • American Journal of Respiratory Cell and Molecular Biology, May 2014, American Thoracic Society

    Matthias Gaestel

  23. The Role of Mammalian MAPK Signaling in Regulation of Cytokine mRNA Stability and Translation

    Article • Journal of Interferon & Cytokine Research, April 2014, Mary Ann Liebert Inc

    Matthias Gaestel

  24. MAPKAP Kinase 2 (MK2)-Dependent and -Independent Models of Blister Formation in Pemphigus Vulgaris

    Article • Journal of Investigative Dermatology, January 2014, Elsevier

    Matthias Gaestel

  25. Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production

    Article • Biochemical Journal, December 2013, Portland Press Ltd.

    Matthias Gaestel, Manoj B Menon

  26. Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

    Article • Proceedings of the National Academy of Sciences, September 2013, Proceedings of the National Academy of Sciences

    Matthias Gaestel, Manoj B Menon

  27. Cross Talk between the Akt and p38  Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

    Article • Molecular and Cellular Biology, August 2013, ASM Journals

    Matthias Gaestel

  28. LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP

    Article • Cellular Signalling, June 2013, Elsevier

    Matthias Gaestel

  29. Mitogen-Activated Protein Kinase-Activated Protein Kinases 2 and 3 Regulate SERCA2a Expression and Fiber Type Composition To Modulate Skeletal Muscle and Cardiomyocyte Function

    Article • Molecular and Cellular Biology, April 2013, ASM Journals

    Matthias Gaestel, Manoj B Menon

  30. Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover

    Article • Journal of Bone and Mineral Research, March 2013, Wiley

    Matthias Gaestel

  31. Crucial Roles of the Protein Kinases MK2 and MK3 in a Mouse Model of Glomerulonephritis

    Article • PLoS ONE, January 2013, PLOS

    Matthias Gaestel

  32. p38  Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin

    Article • The Journal of Immunology, January 2013, The American Association of Immunologists

    Matthias Gaestel

  33. What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition

    Article • Biological Chemistry, January 2013, De Gruyter

    Matthias Gaestel

  34. Retraction notice to “Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target” [J. Mol. Cell. Cardiol. 42 (2007) 981–990]

    Article • Journal of Molecular and Cellular Cardiology, November 2012, Elsevier

    Matthias Gaestel

  35. The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest

    Article • Cell Cycle, October 2012, Taylor & Francis

    Matthias Gaestel, Dr Sandra Guaita-Esterurelas

  36. The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

    Article • PLoS Genetics, September 2012, PLOS

    Matthias Gaestel

  37. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

    Article • The EMBO Journal, August 2012, Wiley

    Matthias Gaestel

  38. The Extracellular Signal-Regulated Kinase 3 (Mitogen-Activated Protein Kinase 6 [MAPK6])-MAPK-Activated Protein Kinase 5 Signaling Complex Regulates Septin Function and Dendrite Morphology

    Article • Molecular and Cellular Biology, April 2012, ASM Journals

    Matthias Gaestel, Manoj B Menon

  39. Guidelines for the use and interpretation of assays for monitoring autophagy

    Article • Autophagy, April 2012, Taylor & Francis

    Dave Bridges, Professor CIRO ISIDORO, Professor George Perry, Dr Takeshi Noda, Professor Nektarios Tavernarakis, Matthias Gaestel, Dr Francesca Demarchi, Maria Vaccaro, Juan Segura-Aguilar, Leonardo Travassos, Manoj B Menon, Isabelle Dugail, Dr Legembre Patrick, Dr Marc Etienne Poirot, Professor Paula I. Moreira, Executive Director, The Hormel Institute Robert Clarke, Professor Godefridus J Peters

  40. Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling

    Article • Journal of Cellular Physiology, January 2012, Wiley

    Matthias Gaestel

  41. Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2011, Elsevier

    Matthias Gaestel

  42. Monitoring protein–protein interactions in mammalian cells by trans -SUMOylation

    Article • Biochemical Journal, September 2011, Portland Press Ltd.

    Matthias Gaestel

  43. Small-Molecule Protein and Lipid Kinase Inhibitors in Inflammation and Specific Models for Their Evaluation

    Article • August 2011, Springer Science + Business Media

    Matthias Gaestel

  44. SB202190-Induced Cell Type-Specific Vacuole Formation and Defective Autophagy Do Not Depend on p38 MAP Kinase Inhibition

    Article • PLoS ONE, August 2011, PLOS

    Matthias Gaestel, Manoj B Menon

  45. Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3

    Article • Journal of Biological Chemistry, May 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  46. The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis

    Article • Molecular Cell, February 2011, Elsevier

    Matthias Gaestel

  47. Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Angiotensin II-Induced Inflammation and Hypertension: Regulation of Oxidative Stress

    Article • Hypertension, December 2010, Wolters Kluwer Health

    Matthias Gaestel

  48. Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins

    Article • Biochemical Society Transactions, December 2010, Portland Press Ltd.

    Matthias Gaestel

  49. MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin

    Article • Biochemical Pharmacology, December 2010, Elsevier

    Matthias Gaestel, Manoj B Menon

  50. Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

    Article • Nucleic Acids Research, November 2010, Oxford University Press (OUP)

    Matthias Gaestel, Manoj B Menon

  51. Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Contributes to Secondary Damage after Spinal Cord Injury

    Article • Journal of Neuroscience, October 2010, Society for Neuroscience

    Matthias Gaestel

  52. Characterization of a novel MK3 splice variant from murine ventricular myocardium

    Article • Cellular Signalling, October 2010, Elsevier

    Matthias Gaestel

  53. p38 MAP Kinase and MAPKAP Kinases MK2/3 Cooperatively Phosphorylate Epithelial Keratins

    Article • Journal of Biological Chemistry, August 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel, Manoj B Menon

  54. Characterization of the expression and regulation of MK5 in the murine ventricular myocardium

    Article • Cellular Signalling, July 2010, Elsevier

    Matthias Gaestel

  55. MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR

    Article • The FASEB Journal, May 2010, Federation of American Societies For Experimental Biology (FASEB)

    Matthias Gaestel

  56. Regulation of vimentin intermediate filaments in endothelial cells by hypoxia

    Article • AJP Cell Physiology, April 2010, American Physiological Society

    Matthias Gaestel

  57. TRIF Signaling Stimulates Translation of TNF-  mRNA via Prolonged Activation of MK2

    Article • The Journal of Immunology, April 2010, The American Association of Immunologists

    Matthias Gaestel

  58. p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Matthias Gaestel

  59. Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation

    Article • Journal of Cell Science, March 2010, The Company of Biologists

    Matthias Gaestel

  60. The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in the p38/TNF-α Pathway of Systemic and Cutaneous Inflammation

    Article • Journal of Investigative Dermatology, February 2010, Elsevier

    Matthias Gaestel

  61. The p38 MAPK Regulates IL-24 Expression by Stabilization of the 3′ UTR of IL-24 mRNA

    Article • PLoS ONE, January 2010, PLOS

    Matthias Gaestel

  62. MAPKAPK-2 Signaling Is Critical for Cutaneous Wound Healing

    Article • Journal of Investigative Dermatology, January 2010, Elsevier

    Matthias Gaestel

  63. Biological monitoring of non-thermal effects of mobile phone radiation: recent approaches and challenges

    Article • Biological Reviews, December 2009, Wiley

    Matthias Gaestel

  64. Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration

    Article • Cell Motility and the Cytoskeleton, December 2009, Wiley

    Matthias Gaestel, Manoj B Menon

  65. MK2 regulates the early stages of skin tumor promotion

    Article • Carcinogenesis, October 2009, Oxford University Press (OUP)

    Matthias Gaestel

  66. Modulation of HSP27 alters hypoxia-induced endothelial permeability and related signaling pathways

    Article • Journal of Cellular Physiology, September 2009, Wiley

    Matthias Gaestel

  67. Peptides as Signaling Inhibitors for Mammalian MAP Kinase Cascades

    Article • Current Pharmaceutical Design, July 2009, Bentham Science Publishers

    Matthias Gaestel

  68. Targeting innate immunity protein kinase signalling in inflammation

    Article • Nature Reviews Drug Discovery, June 2009, Nature

    Matthias Gaestel

  69. The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages

    Article • FEBS Letters, May 2009, Wiley

    Matthias Gaestel

  70. MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells

    Article • The EMBO Journal, April 2009, Wiley

    Matthias Gaestel

  71. MAPK-activated Protein Kinase 2 Differentially Regulates Plasmodium falciparum Glycosylphosphatidylinositol-induced Production of Tumor Necrosis Factor-  and Interleukin-12 in Macrophages

    Article • Journal of Biological Chemistry, April 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  72. Reduced Oxazolone-Induced Skin Inflammation in MAPKAP Kinase 2 Knockout Mice

    Article • Journal of Investigative Dermatology, April 2009, Elsevier

    Matthias Gaestel

  73. Mitogen Activated Protein Kinase Activated Protein Kinase 2 Regulates Actin Polymerization and Vascular Leak in Ventilator Associated Lung Injury

    Article • PLoS ONE, February 2009, PLOS

    Matthias Gaestel

  74. RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells: DEPENDENCE ON TRAF2 AND TAK1

    Article • Journal of Biological Chemistry, February 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  75. MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia

    Article • Cell Stress and Chaperones, February 2009, Springer Science + Business Media

    Matthias Gaestel

  76. NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway

    Article • Nature Medicine, February 2009, Nature

    Matthias Gaestel

  77. Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation

    Article • Nucleic Acids Research, December 2008, Oxford University Press (OUP)

    Matthias Gaestel

  78. MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization

    Article • European Journal of Neuroscience, August 2008, Wiley

    Matthias Gaestel

  79. MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

    Article • Journal of Neurochemistry, June 2008, Wiley

    Matthias Gaestel

  80. Adenosine increases calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries

    Article • Acta Physiologica, May 2008, Wiley

    Matthias Gaestel

  81. Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy

    Article • Nephrology Dialysis Transplantation, March 2008, Oxford University Press (OUP)

    Matthias Gaestel

  82. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

    Article • Biochemical Journal, February 2008, Portland Press Ltd.

    Matthias Gaestel

  83. MK2 and MK3 - a pair of isoenzymes?

    Article • Frontiers in Bioscience, January 2008, Frontiers in Bioscience

    Matthias Gaestel

  84. Corrigendum: Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ

    Article • Nature Immunology, January 2008, Nature

    Matthias Gaestel

  85. Systemic Deficiency of the MAP Kinase Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

    Article • Circulation Research, November 2007, Wolters Kluwer Health

    Matthias Gaestel

  86. Lack of MK2 Inhibits Myofibroblast Formation and Exacerbates Pulmonary Fibrosis

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2007, American Thoracic Society

    Matthias Gaestel

  87. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

    Article • Nature Immunology, September 2007, Nature

    Matthias Gaestel

  88. Protein Kinases as Small Molecule Inhibitor Targets in Inflammation

    Article • Current Medicinal Chemistry, September 2007, Bentham Science Publishers

    Matthias Gaestel

  89. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation

    Article • Nucleic Acids Research, August 2007, Oxford University Press (OUP)

    Matthias Gaestel

  90. Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands

    Article • Molecular Immunology, July 2007, Elsevier

    Matthias Gaestel

  91. MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation

    Article • The Journal of Experimental Medicine, June 2007, Rockefeller University Press

    Matthias Gaestel

  92. MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization

    Article • Biochemical and Biophysical Research Communications, June 2007, Elsevier

    Matthias Gaestel

  93. RETRACTED: Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target

    Article • Journal of Molecular and Cellular Cardiology, May 2007, Elsevier

    Matthias Gaestel

  94. Ubc9 fusion–directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation

    Article • Nature Methods, February 2007, Nature

    Matthias Gaestel

  95. Smooth muscle α-actin expression and myofibroblast differentiation by TGFβ are dependent upon MK2

    Article • Journal of Cellular Biochemistry, January 2007, Wiley

    Matthias Gaestel

  96. CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

    Article • Cellular Signalling, November 2006, Elsevier

    Matthias Gaestel

  97. The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

    Article • Molecular and Cellular Biology, October 2006, ASM Journals

    Matthias Gaestel

  98. Characterization of the Atypical MAPK ERK4 and Its Activation of the MAPK-activated Protein Kinase MK5

    Article • Journal of Biological Chemistry, September 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  99. Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor

    Article • Journal of the American College of Cardiology, August 2006, Elsevier

    Matthias Gaestel

  100. Analysis of Properties of Small Heat Shock Protein Hsp25 in MAPK-activated Protein Kinase 2 (MK2)-deficient Cells: MK2-DEPENDENT INSOLUBILIZATION OF Hsp25 OLIGOMERS CORRELATES WITH SUSCEPTIBILITY TO STRESS

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  101. MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity: RELEVANCE TO NEUROINFLAMMATION IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER DISEASE

    Article • Journal of Biological Chemistry, June 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  102. Gene deletion of MK2 inhibits TNF-  and IL-6 and protects against cerulein-induced pancreatitis

    Article • AJP Gastrointestinal and Liver Physiology, June 2006, American Physiological Society

    Matthias Gaestel

  103. TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway

    Article • AJP Lung Cellular and Molecular Physiology, May 2006, American Physiological Society

    Matthias Gaestel

  104. Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element

    Article • Molecular and Cellular Biology, March 2006, ASM Journals

    Matthias Gaestel

  105. MAPKAP kinases — MKs — two's company, three's a crowd

    Article • Nature Reviews Molecular Cell Biology, January 2006, Nature

    Matthias Gaestel

  106. Phosphorylation of HSF1 by MAPK-Activated Protein Kinase 2 on Serine 121, Inhibits Transcriptional Activity and Promotes HSP90 Binding

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  107. Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways

    Article • AJP Cell Physiology, September 2005, American Physiological Society

    Matthias Gaestel

  108. HDM2 phosphorylation by MAPKAP kinase 2

    Article • Oncogene, January 2005, Nature

    Matthias Gaestel

  109. Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons

    Article • Journal of Biological Chemistry, January 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel, David Levy

  110. Scaffolding by ERK3 regulates MK5 in development

    Article • The EMBO Journal, November 2004, Wiley

    Matthias Gaestel

  111. Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell

    Article • Journal of Applied Physiology, May 2004, American Physiological Society

    Matthias Gaestel

  112. A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis

    Article • Biochemical and Biophysical Research Communications, April 2004, Elsevier

    Matthias Gaestel

  113. P66ShcAinteracts with MAPKAP kinase 2 and regulates its activity

    Article • FEBS Letters, March 2004, Wiley

    Matthias Gaestel

  114. IFN-  Regulation in Anti-CD4 Antibody-Induced T Cell Unresponsiveness

    Article • Journal of the American Society of Nephrology, March 2004, American Society of Nephrology

    Matthias Gaestel

  115. Elimination of Protein Kinase MK5/PRAK Activity by Targeted Homologous Recombination

    Article • Molecular and Cellular Biology, November 2003, ASM Journals

    Matthias Gaestel

  116. Role of p38  Map Kinase in Type I Interferon Signaling

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel, David Levy

  117. Analysis of the Interaction of Small Heat Shock Proteins with Unfolding Proteins

    Article • Journal of Biological Chemistry, March 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  118. Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization

    Article • Biochemical and Biophysical Research Communications, February 2003, Elsevier

    Matthias Gaestel

  119. Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease

    Article • The Journal of Experimental Medicine, December 2002, Rockefeller University Press

    Matthias Gaestel

  120. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

    Article • The EMBO Journal, December 2002, Wiley

    Matthias Gaestel

  121. Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?

    Article • Biochemical Society Transactions, November 2002, Portland Press Ltd.

    Matthias Gaestel

  122. Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Deficiency Protects Brain from Ischemic Injury in Mice

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  123. Cytoskeletal Changes in Hypoxic Pulmonary Endothelial Cells Are Dependent on MAPK-activated Protein Kinase MK2

    Article • Journal of Biological Chemistry, August 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  124. Distinct Cellular Functions of MK2

    Article • Molecular and Cellular Biology, July 2002, ASM Journals

    Matthias Gaestel

  125. In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance

    Article • Biological Chemistry, January 2002, De Gruyter

    Matthias Gaestel

  126. Identification of a Phosphorylation Site on Skeletal Muscle Myosin Light Chain Kinase That Becomes Phosphorylated during Muscle Contraction

    Article • Archives of Biochemistry and Biophysics, January 2002, Elsevier

    Matthias Gaestel

  127. MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels

    Article • Journal of Biological Chemistry, December 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  128. FRET‐based detection of different conformations of MK2

    Article • EMBO Reports, August 2001, EMBO

    Matthias Gaestel

  129. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology

    Article • The EMBO Journal, July 2001, Wiley

    Matthias Gaestel

  130. Heat Shock Protein 27 Is a Substrate of cGMP-dependent Protein Kinase in Intact Human Platelets: PHOSPHORYLATION-INDUCED ACTIN POLYMERIZATION CAUSED BY HSP27 MUTANTS

    Article • Journal of Biological Chemistry, November 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  131. Mouse Hsp25, a small heat shock protein

    Article • European Journal of Biochemistry, April 2000, Wiley

    Matthias Gaestel

  132. Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway

    Article • Proceedings of the National Academy of Sciences, November 1999, Proceedings of the National Academy of Sciences

    Matthias Gaestel

  133. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism

    Article • The EMBO Journal, September 1999, Wiley

    Matthias Gaestel

  134. Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction

    Article • Journal of Biological Chemistry, September 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  135. Stress-induced Stimulation of Early Growth Response Gene-1 by p38/Stress-activated Protein Kinase 2 Is Mediated by a cAMP-responsive Promoter Element in a MAPKAP Kinase 2-independent Manner

    Article • Journal of Biological Chemistry, July 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  136. Regulation of Hsp27 Oligomerization, Chaperone Function, and Protective Activity against Oxidative Stress/Tumor Necrosis Factor   by Phosphorylation

    Article • Journal of Biological Chemistry, July 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  137. The Dynamics of Hsp25 Quaternary Structure: STRUCTURE AND FUNCTION OF DIFFERENT OLIGOMERIC SPECIES

    Article • Journal of Biological Chemistry, May 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  138. MAPKAP Kinase 2 Phosphorylates Serum Response Factor in Vitro and in Vivo

    Article • Journal of Biological Chemistry, May 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Michael A Cahill, Matthias Gaestel

  139. Preoperative Treatment of Rectal Cancer with Radiation, Chemotherapy and Hyperthermia: Analysis of Treatment Efficacy and Heat-Shock Response

    Article • Radiation Research, April 1999, JSTOR

    Matthias Gaestel

  140. Thiol/disulfide exchange between small heat shock protein 25 and glutathione

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, October 1998, Elsevier

    Matthias Gaestel

  141. Evidence for ahsp25-Specific Mechanism Involved in Transcriptional Activation by Heat Shock

    Article • Experimental Cell Research, July 1998, Elsevier

    Matthias Gaestel

  142. Leptomycin B-sensitive nuclear export of MAPKAP kinase 2is regulated by phosphorylation

    Article • The EMBO Journal, June 1998, Wiley

    Matthias Gaestel

  143. Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFα- and hydrogen peroxide-induced cell death

    Article • Journal of Cellular Biochemistry, June 1998, Wiley

    Matthias Gaestel

  144. Small Heat-Shock Protein Family: Function in Health and Disease

    Article • Annals of the New York Academy of Sciences, June 1998, Wiley

    Matthias Gaestel

  145. The effect of the intersubunit disulfide bond on the structural and functional properties of the small heat shock protein Hsp25

    Article • International Journal of Biological Macromolecules, May 1998, Elsevier

    Matthias Gaestel

  146. [28] Purification and characterization of small heat shock proteins

    Article • January 1998, Elsevier

    Matthias Gaestel

  147. Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2 -mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25

    Article • Cell Stress and Chaperones, January 1998, Springer Science + Business Media

    Matthias Gaestel

  148. PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype

    Article • Journal of Cellular Physiology, December 1997, Wiley

    Matthias Gaestel

  149. CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

    Article • The EMBO Journal, March 1997, Wiley

    Matthias Gaestel

  150. Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation

    Article • The EMBO Journal, January 1997, Wiley

    Matthias Gaestel

  151. The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27

    Article • Cell Stress and Chaperones, January 1997, Springer Science + Business Media

    Matthias Gaestel

  152. P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional Level

    Article • Biochemical and Biophysical Research Communications, January 1997, Elsevier

    Matthias Gaestel

  153. Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade

    Article • FEBS Letters, October 1996, Wiley

    Matthias Gaestel

  154. The anti-cancer drug cisplatin induces HSP25 in Ehrlich ascites tumor cells by a mechanism different from transcriptional stimulation influencing predominantly HSP25 translation

    Article • International Journal of Cancer, June 1996, Wiley

    Matthias Gaestel

  155. Dimer structure as a minimum cooperative subunit of small heat-shock proteins

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, December 1995, Elsevier

    Matthias Gaestel

  156. Constitutive Activation of Mitogen-activated Protein Kinase-activated Protein Kinase 2 by Mutation of Phosphorylation Sites and an A-helix Motif

    Article • Journal of Biological Chemistry, November 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Matthias Gaestel

  157. 1H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids

    Article • FEBS Letters, August 1995, Wiley

    Matthias Gaestel

  158. Structural and functional homology between periplasmic bacterial molecular chaperones and small heat shock proteins

    Article • FEMS Immunology & Medical Microbiology, July 1995, Wiley

    Matthias Gaestel

  159. MAPKAP kinase 2 is activated by heat shock and TNF-α: In vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade

    Article • Journal of Cellular Biochemistry, February 1995, Wiley

    Matthias Gaestel

  160. αA-crystallin confers cellular thermoresistance

    Article • FEBS Letters, November 1994, Wiley

    Matthias Gaestel

  161. Characterization of the Proline-Rich Region of Mouse Mapkap Kinase2: Influence on Catalytic Properties and Binding to the c-abl-SH3 Domain in Vitro

    Article • Biochemical and Biophysical Research Communications, September 1994, Elsevier

    Matthias Gaestel

  162. The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain

    Article • FEBS Letters, December 1993, Wiley

    Matthias Gaestel

  163. Comparison of the homologous carboxy-terminal domain and tail of α-crystallin and small heat shock protein

    Article • Molecular Biology Reports, October 1993, Springer Science + Business Media

    Matthias Gaestel

  164. Structure and organisation of a murine gene encoding small heat-shock protein Hsp25

    Article • Gene, June 1993, Elsevier

    Matthias Gaestel

  165. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

    Article • FEBS Letters, November 1992, Wiley

    Matthias Gaestel

  166. Over-expression of the small heat-shock protein, hsp25, inhibits growth of Ehrlich ascites tumor cells

    Article • FEBS Letters, September 1992, Wiley

    Matthias Gaestel

  167. Supramolecular structure of the recombinant murine small heat shock protein hsp25

    Article • FEBS Letters, August 1991, Wiley

    Matthias Gaestel

  168. Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosa

    Article • Biochemical and Biophysical Research Communications, June 1989, Elsevier

    Matthias Gaestel

  169. Bispecific antibody-producing hybrid hybridomas selected by a fluorescence activated cell sorter

    Article • Journal of Immunological Methods, February 1987, Elsevier

    Matthias Gaestel

  170. Simple preparative two-step purification of interleukin-2 from culture medium of lectin stimulated normal human lymphocytes

    Article • Journal of Immunological Methods, March 1986, Elsevier

    Matthias Gaestel

  171. The influence of Ca2+ on the lateral lipid distribution and phase transition in phosphatidylethanolamine/phosphatidylserine vesicles

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, January 1984, Elsevier

    Matthias Gaestel

  172. A theoretical approach to cluster formation in biological membranes

    Article • Biosystems, January 1984, Elsevier

    Matthias Gaestel

  173. Lateral lipid distribution and phase transition in phosphatidylethanolamine/phosphatidylserine vesicles

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 1983, Elsevier

    Matthias Gaestel

  174. The electric potential profile across the erythrocyte membrane

    Article • Journal of Theoretical Biology, May 1982, Elsevier

    Matthias Gaestel

  175. Protein Kinases as Substrates for SAPKs

    Article • Springer Science + Business Media

    Matthias Gaestel