All Stories

  1. Deciphering the role of the hendecad-repeat coiled-coil domain of TRIM72 in membrane curvature recognition
  2. SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity
  3. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
  4. Quo Vadis Experimental Structural Biology?
  5. Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
  6. Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates
  7. Structural insights into ClpP protease side exit pore‐opening by a pH drop coupled with substrate hydrolysis
  8. LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
  9. Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway
  10. Crystal structure of yeast Gid10 in complex with Pro/N-degron
  11. Dynamics and Entropy of Cyclohexane Rings Control pH-Responsive Reactivity
  12. Opening the side exit pores of ClpP by lowering the pH of proteolytic chamber coupled with substrate hydrolysis
  13. Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction
  14. Phospholipid transfer function of PTPIP51 at mitochondria‐associated ER membranes
  15. UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
  16. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  17. Structural basis for the N‐degron specificity of ClpS1 from Arabidopsis thaliana
  18. Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis
  19. TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages
  20. Enhancing Protein Crystallization under a Magnetic Field
  21. Targeted Degradation of Transcription Coactivator SRC‐1 through the N‐Degron Pathway
  22. Use of the LC3B-fusion technique for biochemical and structural studies of proteins involved in the N-degron pathway
  23. Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant
  24. A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser
  25. Structural and Mechanistic Insights into Caffeine Degradation by the Bacterial N-Demethylase Complex
  26. Structural studies of a novel ubiquitin-modifying enzyme, SdeA, using various tools
  27. Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex
  28. MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity
  29. eIF4A3 Phosphorylation by CDKs Affects NMD during the Cell Cycle
  30. A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate
  31. pH-dependent regulation of SQSTM1/p62 during autophagy
  32. Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
  33. The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation
  34. Structural insight into degradation mechanism of N-end rule substrates by p62/SQSTM1 selective autophagy adaptor
  35. Structural and Biochemical Study of the Mono ADP-Ribosyltransferase Domain of SdeA, a Ubiquitylating/Deubiquitylating Enzyme from Legionella pneumophila
  36. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
  37. Unveiling the pathway to Z-DNA in the protein-induced B–Z transition
  38. Structural Studies of Peptide Binding Interaction of HCV IRES Domain IV
  39. A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ
  40. An assessment tool for determination of coiled-coil orientation
  41. ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils
  42. Structural Characterization of RNA Recognition Motif-2 Domain of SART3
  43. The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane
  44. Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway
  45. The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism
  46. Structural Characterization of pre-miRNA 155
  47. A facile method to prepare large quantities of active caspase-3 overexpressed by auto-induction in the C41(DE3) strain
  48. Structure biology of selective autophagy receptors
  49. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  50. Structural stability of CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1
  51. Mitochondrial ATP synthase activity is impaired by suppressed O -GlcNAcylation in Alzheimer's disease
  52. mTRAQ-based quantitative analysis combined with peptide fractionation based on cysteinyl peptide enrichment
  53. A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation
  54. Swapping of interaction partners with ATG5 for autophagosome maturation
  55. PEA-15 facilitates EGFR dephosphorylation
  56. Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners
  57. eIF4AIII enhances translation of nuclear cap-binding complex–bound mRNAs by promoting disruption of secondary structures in 5′UTR
  58. Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase
  59. Crystallization and preliminary X-ray analysis of the C-terminal fragment of Ski7 fromSaccharomyces cerevisiae
  60. Insights into the Molecular Evolution of HslU ATPase through Biochemical and Mutational Analyses
  61. Expansion of the clinicopathological and mutational spectrum of Perry syndrome
  62. In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe
  63. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling
  64. Structural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) from Trypanosoma brucei
  65. Change in single cystathionine β-synthase domain-containing protein from a bent to flat conformation upon adenosine monophosphate binding
  66. Renal Protective Effects of Toll-like Receptor 4 Signaling Blockade in Type 2 Diabetic Mice
  67. Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8
  68. Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases
  69. Crystal structure of the single cystathionine β-synthase domain-containing protein CBSX1 from Arabidopsis thaliana
  70. Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20
  71. Structures of the ribosome-inactivating protein from barley seeds reveal a unique activation mechanism
  72. Structure of the autophagic E2 enzyme Atg10
  73. Crystal structure ofPyrococcus furiosusPF2050, a member of the DUF2666 protein family
  74. Correction
  75. Structural insights into the conformational diversity of ClpP from Bacillus subtilis
  76. Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
  77. Single Cystathionine  -Synthase Domain-Containing Proteins Modulate Development by Regulating the Thioredoxin System in Arabidopsis
  78. Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome
  79. Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1
  80. Crystal structures of two CBSX proteins fromArabidopsis thaliana
  81. Structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) fromHaloferax volcanii
  82. Corrigendum to “Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii” [Biochem. Biophys. Res. Commun. 405 (2011) 112–117]
  83. Crystal Structure of a Coiled-Coil Domain from Human ROCK I
  84. Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii
  85. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
  86. Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing
  87. Expression, purification and biochemical characterization of the N-terminal regions of human TIG3 and HRASLS3 proteins
  88. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
  89. A simple technique to convert sitting-drop vapor diffusion into hanging-drop vapor diffusion by solidifying the reservoir solution with agarose
  90. Biochemical and structural characterization of 5′-methylthioadenosine nucleosidases from Arabidopsis thaliana
  91. Conformational Change of ClpP from Bacillus subtilis Characterized by Electron Microscopic study
  92. Crystal structure of PRY-SPRY domain of human TRIM72
  93. Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy
  94. Real-time imaging of NF-AT nucleocytoplasmic shuttling with a photoswitchable fluorescence protein in live cells
  95. A preliminary crystallographic study of CDCP2 fromArabidopsis thaliana
  96. Structural and biochemical characterization of ClpP fromBacillus subtilis
  97. Structural comparison of 5′-methylthioadenosine nucleosidases fromArabidopsis thaliana
  98. Purification, crystallization and preliminary X-ray diffraction analysis of a cystathionine β-synthase domain-containing protein, CDCP2, fromArabidopsis thaliana
  99. A Role for a Menthone Reductase in Resistance against Microbial Pathogens in Plants
  100. A degradation signal recognition in prokaryotes
  101. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(β-amino ester) block copolymer micelles for cancer therapy
  102. Structural and Functional Insights into Dom34, a Key Component of No-Go mRNA Decay
  103. The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding
  104. Structural Basis of SspB-tail Recognition by the Zinc Binding Domain of ClpX
  105. Structural characterization of the photoswitchable fluorescent protein Dronpa-C62S
  106. STAM–AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH
  107. Crystal structure of 5′-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-Å resolution
  108. Crystal Structure of the FERM Domain of Focal Adhesion Kinase
  109. Characterization of the HslU chaperone affinity for HslV protease
  110. Crystal Structure of the Bowman–Birk Inhibitor from Barley Seeds in Ternary Complex with Porcine Trypsin
  111. Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair
  112. Proteomics-based Target Identification: BENGAMIDES AS A NEW CLASS OF METHIONINE AMINOPEPTIDASE INHIBITORS
  113. Structural Basis of Degradation Signal Recognition by SspB, a Specificity-Enhancing Factor for the ClpXP Proteolytic Machine
  114. Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes
  115. Homotetrameric Structure of the SNAP-23 N-terminal Coiled-coil Domain
  116. SAP couples Fyn to SLAM immune receptors
  117. Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV
  118. Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)
  119. Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor
  120. Crystal Structure of Klebsiella aerogenesUreE, a Nickel-binding Metallochaperone for Urease Activation
  121. The Quaternary Arrangement of HslU and HslV in a Cocrystal: A Response to Wang, Yale
  122. Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography
  123. Mutational studies on HslU and its docking mode with HslV
  124. Docking of components in a bacterial complex
  125. Nucleoside diphosphate kinase from the hyperthermophilic archaeonMethanococcus jannaschii: overexpression, crystallization and preliminary X-ray crystallographic analysis
  126. Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family
  127. Crystallization and preliminary X-ray crystallographic analysis ofEscherichia coliCyaY, a structural homologue of human frataxin
  128. Crystallization and preliminary X-ray diffraction analysis ofSaccharomyces cerevisiaeYgr203p, a homologue of Acr2 arsenate reductase
  129. Crystallization and preliminary X-ray crystallographic analysis of human nucleoside diphosphate kinase A
  130. Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications
  131. Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae
  132. Crystal structure of a 16 kda double-headed bowman-birk trypsin inhibitor from barley seeds at 1.9 Å resolution
  133. Crystallization and preliminary X-ray analysis of Saccharomyces cerevisiae Ypd1p, a key intermediate in phosphorelay signal transduction
  134. Crystallization and preliminary X-ray analysis of a complex between the Bowman–Birk trypsin inhibitor from barley and porcine pancreatic trypsin
  135. Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin in complex with chymotrypsin
  136. Crystallization and preliminary X-ray crystallographic analysis of deoxycytidylate hydroxymethylase from bacteriophage T4
  137. Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex
  138. A thermostable xylose isomerase fromThermus caldophilus: biochemical characterization, crystallization and preliminary X-ray analysis
  139. Preliminary X-ray crystallographic analysis of Bowman–Birk trypsin inhibitor from barley seeds
  140. Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator
  141. Crystal structure of carboxylesterase from Pseudomonas fluorescens, an α/β hydrolase with broad substrate specificity
  142. The crystal structure of a triacylglycerol lipase from Pseudomonas cepacia reveals a highly open conformation in the absence of a bound inhibitor
  143. Crystal structure analyses of uncomplexed ecotin in two crystal forms: Implications for its function and stability
  144. Crystal structure of the complex of porcine pancreatic trypsin with Kunitz-type soybean trypsin inhibitor
  145. Refined Structure of the Chitinase from Barley Seeds at 2.0 Å Resolution
  146. Crystal structure of Bacillus licheniformis α-Amylase at 1.7resolution
  147. Crystal structure of an uncleaved α 1 -antitrypsin reveals the conformation of its inhibitory reactive loop
  148. Crystallization and preliminary X-ray crystallographic analysis of DNA polymerase fromThermus aquaticus
  149. Crystallization, molecular replacement solution, and refinement of tetrameric β-amylase from sweet potato
  150. Crystallization and preliminary X-ray crystallographic study of ribosome-inactivating protein from barley seeds
  151. Crystallization and preliminary X-ray crystallographic analysis of chitinase from barley seeds