All Stories

  1. Empowering the NSC-34 cell line as a motor neuron model: cytosine arabinoside's action
  2. A Closer Look at Histamine in Drosophila
  3. Further arguments in favor of the biological relevance of purinergic receptors: the novel emergence of a purinergic signature
  4. Machine learning as a new tool in neurological disease prevention, diagnosis, and treatment
  5. Delineating Purinergic Signaling in Drosophila
  6. Rethinking purinergic concepts and updating the emerging role of P2X7 and P2X4 in amyotrophic lateral sclerosis
  7. Vitamin B6 rescues insulin resistance and glucose‐induced DNA damage caused by reduced activity of Drosophila PI3K
  8. Repurposing Histaminergic Drugs in Multiple Sclerosis
  9. S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis
  10. Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model
  11. Growing role of S100B protein as a putative therapeutic target for neurological- and nonneurological-disorders
  12. Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers
  13. Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis
  14. Where and Why Modeling Amyotrophic Lateral Sclerosis
  15. Activation of skeletal muscle–resident glial cells upon nerve injury
  16. What strikes most when we think of Geoff
  17. P2X7 Receptor Agonist 2′(3′)-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington’s Disease
  18. Nerve Growth Factor Neutralization Promotes Oligodendrogenesis by Increasing miR-219a-5p Levels
  19. Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2
  20. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  21. The Histamine and Multiple Sclerosis Alliance: Pleiotropic Actions and Functional Validation
  22. Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
  23. Duality of P2X7 Receptor in Amyotrophic Lateral Sclerosis
  24. P2X7 Receptor in the Management of Energy Homeostasis: Implications for Obesity, Dyslipidemia, and Insulin Resistance
  25. The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing—Remitting Multiple Sclerosis Mouse Model
  26. Functional microglia neurotransmitters in amyotrophic lateral sclerosis
  27. Histamine beyond its effects on allergy: Potential therapeutic benefits for the treatment of Amyotrophic Lateral Sclerosis (ALS)
  28. Stimulation of P2X7 Enhances Whole Body Energy Metabolism in Mice
  29. P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
  30. Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS
  31. Histaminergic transmission slows progression of amyotrophic lateral sclerosis
  32. Commentary: Stephen William Hawking (8 January 1942 - 14 March 2018)
  33. Micropatterned Geometry Shape Oligodendrocyte and Microglia Plasticity
  34. Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis
  35. Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis
  36. P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
  37. Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression
  38. Meet Our Editorial Board Member
  39. Purinergic contribution to amyotrophic lateral sclerosis
  40. M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b
  41. New Kid on the Block: Does Histamine Get Along with Inflammation in Amyotrophic Lateral Sclerosis?
  42. MicroRNAs: Newcomers into the ALS Picture
  43. Editorial (Thematic Issue: MiRNAcles in the Brain: What to Wish and What to Fear)
  44. Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
  45. Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
  46. Commentary: (Research Highlights Inflammation, Demyelination and Neurodegeneration: Risky Buddies in Multiple Sclerosis)
  47. P2Y12Receptor on the Verge of a Neuroinflammatory Breakdown
  48. Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
  49. Commentary-1 Research Highlights (Never Underestimate the Power of Adenosine in Multiple Sclerosis)
  50. Commentary: Never Underestimate the Power of Adenosine in Multiple Sclerosis
  51. Commentary: (Research Highlights: “MiRNAcles” in Brain)
  52. Commentary (Brilliant Blue G: What a Little More Colour Can Be)
  53. Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
  54. P2X3 receptor: a novel ‘CASKade’ of signaling?
  55. The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis
  56. Plasticity of primary microglia on micropatterned geometries and spontaneous long-distance migration in microfluidic channels
  57. Metabotropic Purinergic Receptors in Lipid Membrane Microdomains
  58. Metabotropic Purinergic Receptors in Lipid Membrane Microdomains
  59. Editorial [Pharmacology and Therapeutic Activity of Purinergic Drugs for Disorders of the Nervous System]
  60. P2X7 Receptors: Channels, Pores and More
  61. Purinergic Signalling: What is Missing and Needed Next? The Use of Transgenic Mice, Crystallographic Analysis and MicroRNA
  62. ALS: Focus on purinergic signalling
  63. Commentary [ Research Highlights(To miR or Not to miR: That is the Question in ALS Disease ]
  64. Purinergic signalling at the plasma membrane: a multipurpose and multidirectional mode to deal with amyotrophic lateral sclerosis and multiple sclerosis
  65. N-Glycans mutations rule oligomeric assembly and functional expression of P2X3 receptor for extracellular ATP
  66. UDP exerts cytostatic and cytotoxic actions in human neuroblastoma SH-SY5Y cells over-expressing P2Y6 receptor
  67. Effects of Acute Perinatal Asphyxia in the Rat Hippocampus
  68. P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis
  69. The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis
  70. Rapid constitutive and ligand-activated endocytic trafficking of P2X3receptor
  71. A Model of Ischemia-Induced Neuroblast Activation in the Adult Subventricular Zone
  72. Membrane compartments and purinergic signalling: the purinome, a complex interplay among ligands, degrading enzymes, receptors and transporters
  73. Membrane compartments and purinergic signalling
  74. Receptor webs: Can the chunking theory tell us more about it?
  75. Protein cooperation: From neurons to networks
  76. Do ATP and NO interact in the CNS?
  77. Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study
  78. P2 Receptor Antagonist Trinitrophenyl-Adenosine-Triphosphate Protects Hippocampus from Oxygen and Glucose Deprivation Cell Death
  79. Comparative analysis of P2Y4 and P2Y6 receptor architecture in native and transfected neuronal systems
  80. Extracellular adenosine triphosphate induces glutamate transporter-1 expression in hippocampus
  81. P2Y1 receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortex
  82. A novel pathway of cell growth regulation mediated by a PLA2 -derived phosphoinositide metabolite
  83. A Purine Analog-Sensitive Protein Kinase Activity Associates with Trk Nerve Growth Factor Receptors
  84. P2 receptor web: Complexity and fine-tuning
  85. The P2Y4 receptor forms homo-oligomeric complexes in several CNS and PNS neuronal cells
  86. P2X7 Receptor Modulation on Microglial Cells and Reduction of Brain Infarct Caused by Middle Cerebral Artery Occlusion in Rat
  87. Oligodendrocytes express P2Y12 metabotropic receptor in adult rat brain
  88. P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFα and potential role in myocardial cell death
  89. Differences in the neurotoxicity profile induced by ATP and ATPγS in cultured cerebellar granule neurons
  90. ATP regulates oligodendrocyte progenitor migration, proliferation, and differentiation: involvement of metabotropic P2 receptors
  91. Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia
  92. The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells
  93. Metabotropic P2 receptor activation regulates oligodendrocyte progenitor migration and development
  94. Role of the metabotropic P2Y4 receptor during hypoglycemia: cross talk with the ionotropic NMDAR1 receptor
  95. P2X3receptor localizes into lipid rafts in neuronal cells
  96. Synaptic P2X7 and Oxygen/Glucose Deprivation in Organotypic Hippocampal Cultures
  97. 2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines
  98. Overexpression of superoxide dismutase 1 protects against β-amyloid peptide toxicity: effect of estrogen and copper chelators
  99. Pathways of survival induced by NGF and extracellular ATP after growth factor deprivation
  100. Extracellular ATP and Neurodegeneration
  101. Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors
  102. Up-regulation of p2x2, p2x4 receptor and ischemic cell death: prevention by p2 antagonists
  103. Cerebellar lesion up-regulates P2X1 and P2X2 purinergic receptors in precerebellar nuclei
  104. Identification of an Ectokinase Activity in Cerebellar Granule Primary Neuronal Cultures
  105. Extracellular ATP and nerve growth factor intensify hypoglycemia-induced cell death in primary neurons: role of P2 and NGFRp75 receptors
  106. P2 receptor modulation and cytotoxic function in cultured CNS neurons
  107. Interaction between ATP and nerve growth factor signalling in the survival and neuritic outgrowth from PC12 cells
  108. Glucose deprivation and chemical hypoxia: neuroprotection by P2 receptor antagonists
  109. Hypoglycaemia-induced cell death: features of neuroprotection by the P2 receptor antagonist basilen blue
  110. Effect of P2 purinoceptor antagonists on kainate-induced currents in rat cultured neurons
  111. Antagonists of P2 receptor prevent NGF-dependent neuritogenesis in PC12 cells
  112. Neuroprotective effects of modulators of P2 receptors in primary culture of CNS neurones
  113. Characterization of an ecto-phosphorylated protein of cultured cerebellar granule neurons
  114. Characterization of an ecto‐phosphorylated protein of cultured cerebellar granule neurons
  115. Prevention of Glutamate-Evoked Cytotoxicity
  116. Biological Effects of P2 Purinoceptor Modulators in Cultured Primary Cerebellar Granule Neurons
  117. Binding and Functions of Extracellular ATP in Cultured Cerebellar Granule Neurons
  118. Selected P2 purinoceptor modulators prevent glutamate-evoked cytotoxicity in cultured cerebellar granule neurons
  119. Stimulation ofvgfgene expression by NGF is mediated through multiple signal transduction pathways involving protein phosphorylation
  120. Nerve growth factor-activated protein kinase N modulates the cAMP-dependent protein kinase
  121. Development of a method for measuring cell number: Application to CNS primary neuronal cultures
  122. LiCl promotes survival of GABAergic neurons from cerebellum and cerebral cortex: LiCl induces survival of GABAergic neurons
  123. Dexamethasone abolishes the activation by nerve growth factor of protein kinase N: effects of nerve growth factor and dexamethasone on protein kinase N
  124. 6-Methylmercaptopurine Riboside Is a Potent and Selective Inhibitor of Nerve Growth Factor-Activated Protein Kinase N
  125. Nerve Growth Factor (NGF) Responses by Non-Neuronal Cells: Detection by Assay of a Novel NGF-Activated Protein Kinase
  126. Motility, heat, and lactate production in ejaculated bovine sperm
  127. Stimulation of Inositol Incorporation into Lipids of PC 12 Cells by Nerve Growth Factor and Bradykinin
  128. Lithium Stimulation of Membrane-Bound Phospholipase C from PC 12 Cells Exposed to Nerve Growth Factor
  129. Lithium stimulates the binding of GTP to the membranes of PC12 cells cultured with nerve growth factor
  130. NGF Modulates the Synthesis of a Nuclear Lactic Dehydrogenase with Single-stranded DNA-Binding Properties