All Stories

  1. Interleukin-9 Regulates NF-kB-Mediated Activation of Astrocytes in Multiple Sclerosis Brain
  2. Neuroprotection beyond neurons: integrated biomarker-based and astroglia- or microglia-targeted approaches to combat neurodegenerative diseases
  3. Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS
  4. Empowering the NSC-34 cell line as a motor neuron model: cytosine arabinoside's action
  5. Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila
  6. Pan-neuronal expression of human mutant SOD1 in Drosophila impairs survival and motor performance, induces early neuroinflammation and chromosome aberrations
  7. A Closer Look at Histamine in Drosophila
  8. Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism
  9. Dysregulation of alternative splicing underlies synaptic defects in familial amyotrophic lateral sclerosis
  10. Further arguments in favor of the biological relevance of purinergic receptors: the novel emergence of a purinergic signature
  11. Machine learning as a new tool in neurological disease prevention, diagnosis, and treatment
  12. Delineating Purinergic Signaling in Drosophila
  13. Rethinking purinergic concepts and updating the emerging role of P2X7 and P2X4 in amyotrophic lateral sclerosis
  14. Vitamin B6 rescues insulin resistance and glucose‐induced DNA damage caused by reduced activity of Drosophila PI3K
  15. Repurposing Histaminergic Drugs in Multiple Sclerosis
  16. A deep scream into the future
  17. Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1G93Amice
  18. S100B Protein as a Therapeutic Target in Multiple Sclerosis: The S100B Inhibitor Arundic Acid Protects from Chronic Experimental Autoimmune Encephalomyelitis
  19. Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model
  20. Growing role of S100B protein as a putative therapeutic target for neurological- and nonneurological-disorders
  21. Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers
  22. Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis
  23. Where and Why Modeling Amyotrophic Lateral Sclerosis
  24. Activation of skeletal muscle–resident glial cells upon nerve injury
  25. What strikes most when we think of Geoff
  26. P2X7 Receptor Agonist 2′(3′)-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington’s Disease
  27. Nerve Growth Factor Neutralization Promotes Oligodendrogenesis by Increasing miR-219a-5p Levels
  28. Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2
  29. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
  30. The Histamine and Multiple Sclerosis Alliance: Pleiotropic Actions and Functional Validation
  31. Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS
  32. Editorial: Dual Role of Microglia in Health and Disease: Pushing the Balance Towards Repair
  33. Duality of P2X7 Receptor in Amyotrophic Lateral Sclerosis
  34. P2X7 Receptor in the Management of Energy Homeostasis: Implications for Obesity, Dyslipidemia, and Insulin Resistance
  35. The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing—Remitting Multiple Sclerosis Mouse Model
  36. Functional microglia neurotransmitters in amyotrophic lateral sclerosis
  37. Histamine beyond its effects on allergy: Potential therapeutic benefits for the treatment of Amyotrophic Lateral Sclerosis (ALS)
  38. Stimulation of P2X7 Enhances Whole Body Energy Metabolism in Mice
  39. P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
  40. Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS
  41. Histaminergic transmission slows progression of amyotrophic lateral sclerosis
  42. Commentary: Stephen William Hawking (8 January 1942 - 14 March 2018)
  43. Micropatterned Geometry Shape Oligodendrocyte and Microglia Plasticity
  44. Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis
  45. Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis
  46. P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia
  47. Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression
  48. Meet Our Editorial Board Member
  49. Purinergic contribution to amyotrophic lateral sclerosis
  50. MicroRNA-125b regulates microglia activation and motor neuron death in ALS
  51. M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b
  52. New Kid on the Block: Does Histamine Get Along with Inflammation in Amyotrophic Lateral Sclerosis?
  53. MicroRNAs: Newcomers into the ALS Picture
  54. Editorial (Thematic Issue: MiRNAcles in the Brain: What to Wish and What to Fear)
  55. Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
  56. Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis
  57. Commentary: (Research Highlights Inflammation, Demyelination and Neurodegeneration: Risky Buddies in Multiple Sclerosis)
  58. P2Y12Receptor on the Verge of a Neuroinflammatory Breakdown
  59. Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
  60. Commentary-1 Research Highlights (Never Underestimate the Power of Adenosine in Multiple Sclerosis)
  61. Commentary: Never Underestimate the Power of Adenosine in Multiple Sclerosis
  62. Commentary: (Research Highlights: “MiRNAcles” in Brain)
  63. Commentary (Brilliant Blue G: What a Little More Colour Can Be)
  64. Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
  65. P2X3 receptor: a novel ‘CASKade’ of signaling?
  66. The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis
  67. Plasticity of primary microglia on micropatterned geometries and spontaneous long-distance migration in microfluidic channels
  68. Metabotropic Purinergic Receptors in Lipid Membrane Microdomains
  69. Metabotropic Purinergic Receptors in Lipid Membrane Microdomains
  70. Editorial [Pharmacology and Therapeutic Activity of Purinergic Drugs for Disorders of the Nervous System]
  71. P2X7 Receptors: Channels, Pores and More
  72. Purinergic Signalling: What is Missing and Needed Next? The Use of Transgenic Mice, Crystallographic Analysis and MicroRNA
  73. ALS: Focus on purinergic signalling
  74. Commentary [ Research Highlights(To miR or Not to miR: That is the Question in ALS Disease ]
  75. Purinergic signalling at the plasma membrane: a multipurpose and multidirectional mode to deal with amyotrophic lateral sclerosis and multiple sclerosis
  76. N-Glycans mutations rule oligomeric assembly and functional expression of P2X3 receptor for extracellular ATP
  77. UDP exerts cytostatic and cytotoxic actions in human neuroblastoma SH-SY5Y cells over-expressing P2Y6 receptor
  78. Effects of Acute Perinatal Asphyxia in the Rat Hippocampus
  79. P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis
  80. The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis
  81. Rapid constitutive and ligand-activated endocytic trafficking of P2X3receptor
  82. A Model of Ischemia-Induced Neuroblast Activation in the Adult Subventricular Zone
  83. Membrane compartments and purinergic signalling: the purinome, a complex interplay among ligands, degrading enzymes, receptors and transporters
  84. Membrane compartments and purinergic signalling
  85. Receptor webs: Can the chunking theory tell us more about it?
  86. Protein cooperation: From neurons to networks
  87. Do ATP and NO interact in the CNS?
  88. Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study
  89. P2 Receptor Antagonist Trinitrophenyl-Adenosine-Triphosphate Protects Hippocampus from Oxygen and Glucose Deprivation Cell Death
  90. Comparative analysis of P2Y4 and P2Y6 receptor architecture in native and transfected neuronal systems
  91. Extracellular adenosine triphosphate induces glutamate transporter-1 expression in hippocampus
  92. P2Y1 receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortex
  93. A novel pathway of cell growth regulation mediated by a PLA2 -derived phosphoinositide metabolite
  94. A Purine Analog-Sensitive Protein Kinase Activity Associates with Trk Nerve Growth Factor Receptors
  95. P2 receptor web: Complexity and fine-tuning
  96. The P2Y4 receptor forms homo-oligomeric complexes in several CNS and PNS neuronal cells
  97. P2X7 Receptor Modulation on Microglial Cells and Reduction of Brain Infarct Caused by Middle Cerebral Artery Occlusion in Rat
  98. Oligodendrocytes express P2Y12 metabotropic receptor in adult rat brain
  99. P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFα and potential role in myocardial cell death
  100. Differences in the neurotoxicity profile induced by ATP and ATPγS in cultured cerebellar granule neurons
  101. ATP regulates oligodendrocyte progenitor migration, proliferation, and differentiation: involvement of metabotropic P2 receptors
  102. Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia
  103. The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells
  104. Metabotropic P2 receptor activation regulates oligodendrocyte progenitor migration and development
  105. Role of the metabotropic P2Y4 receptor during hypoglycemia: cross talk with the ionotropic NMDAR1 receptor
  106. P2X3receptor localizes into lipid rafts in neuronal cells
  107. Synaptic P2X7 and Oxygen/Glucose Deprivation in Organotypic Hippocampal Cultures
  108. 2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines
  109. Overexpression of superoxide dismutase 1 protects against β-amyloid peptide toxicity: effect of estrogen and copper chelators
  110. Pathways of survival induced by NGF and extracellular ATP after growth factor deprivation
  111. Extracellular ATP and Neurodegeneration
  112. Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors
  113. Up-regulation of p2x2, p2x4 receptor and ischemic cell death: prevention by p2 antagonists
  114. Cerebellar lesion up-regulates P2X1 and P2X2 purinergic receptors in precerebellar nuclei
  115. Identification of an Ectokinase Activity in Cerebellar Granule Primary Neuronal Cultures
  116. Extracellular ATP and nerve growth factor intensify hypoglycemia-induced cell death in primary neurons: role of P2 and NGFRp75 receptors
  117. P2 receptor modulation and cytotoxic function in cultured CNS neurons
  118. Interaction between ATP and nerve growth factor signalling in the survival and neuritic outgrowth from PC12 cells
  119. Glucose deprivation and chemical hypoxia: neuroprotection by P2 receptor antagonists
  120. Hypoglycaemia-induced cell death: features of neuroprotection by the P2 receptor antagonist basilen blue
  121. Effect of P2 purinoceptor antagonists on kainate-induced currents in rat cultured neurons
  122. Antagonists of P2 receptor prevent NGF-dependent neuritogenesis in PC12 cells
  123. Neuroprotective effects of modulators of P2 receptors in primary culture of CNS neurones
  124. Characterization of an ecto-phosphorylated protein of cultured cerebellar granule neurons
  125. Characterization of an ecto‐phosphorylated protein of cultured cerebellar granule neurons
  126. Prevention of Glutamate-Evoked Cytotoxicity
  127. Biological Effects of P2 Purinoceptor Modulators in Cultured Primary Cerebellar Granule Neurons
  128. Purines and cell death
  129. Binding and Functions of Extracellular ATP in Cultured Cerebellar Granule Neurons
  130. Selected P2 purinoceptor modulators prevent glutamate-evoked cytotoxicity in cultured cerebellar granule neurons
  131. Stimulation ofvgfgene expression by NGF is mediated through multiple signal transduction pathways involving protein phosphorylation
  132. Nerve growth factor-activated protein kinase N modulates the cAMP-dependent protein kinase
  133. Development of a method for measuring cell number: Application to CNS primary neuronal cultures
  134. LiCl promotes survival of GABAergic neurons from cerebellum and cerebral cortex: LiCl induces survival of GABAergic neurons
  135. Dexamethasone abolishes the activation by nerve growth factor of protein kinase N: effects of nerve growth factor and dexamethasone on protein kinase N
  136. 6-Methylmercaptopurine Riboside Is a Potent and Selective Inhibitor of Nerve Growth Factor-Activated Protein Kinase N
  137. Nerve Growth Factor (NGF) Responses by Non-Neuronal Cells: Detection by Assay of a Novel NGF-Activated Protein Kinase
  138. Nerve Growth Factor (NGF) Responses by Non-Neuronal Cells: Detection by Assay of a Novel NGF-Activated Protein Kinase
  139. Motility, heat, and lactate production in ejaculated bovine sperm
  140. Stimulation of Inositol Incorporation into Lipids of PC 12 Cells by Nerve Growth Factor and Bradykinin
  141. Lithium Stimulation of Membrane-Bound Phospholipase C from PC 12 Cells Exposed to Nerve Growth Factor
  142. Lithium stimulates the binding of GTP to the membranes of PC12 cells cultured with nerve growth factor
  143. NGF Modulates the Synthesis of a Nuclear Lactic Dehydrogenase with Single-stranded DNA-Binding Properties