Obesity and TCF7L2 variants' additive effect on type 2 diabetes risk in cardiac patients

What is it about?

The study investigated the combined effect of obesity and genotype at DG10S478 and rs12255372 in predicting type 2 diabetes risk in a sample of French Canadian cardiac patients. The genotype DG10S478 and rs12255372 were in Hardy-Weinberg equilibrium and in strong linkage disequilibrium. The rate of diabetes increased with an increasing dose of allele X of DG10S478 or allele T of rs12255372 and among obese compared with nonobese participants. The association was consistent for both groups but stronger in nonobese coronary artery disease patients. The study found that polymorphisms in TCF7L2 and obesity are both associated with an increased risk for type 2 diabetes in their French Canadian sample of cardiac patients.

Featured Image

Why is it important?

This research is important because it investigates the combined effect of obesity and genotype at the DG10S478 and rs12255372 markers in predicting type 2 diabetes risk in a sample of French Canadian cardiac patients. The study confirms that polymorphisms in the TCF7L2 gene and obesity are both associated with an increased risk for type 2 diabetes. The genetic association was stronger in non-obese patients, and genotype T/T at rs12255372 was associated with reduced BMI, confirming previous reports. Key Takeaways: 1. Polymorphisms in the TCF7L2 gene and obesity are independent risk factors for type 2 diabetes. 2. The genetic association was stronger in non-obese patients. 3. Genotype T/T at rs12255372 was associated with reduced BMI. 4. Another variant(s) nearby may account for the linkage of type 2 diabetes to the chromosome 10q region.