What is it about?
We showed that Hepatitis B virus DNA integration into the host genome (a commonly-observed but poorly-characterised form of the virus that has been associated with liver cancer development) occurs extremely early after virus infection, rather than after decades of infection as previously thought. We have also established a novel cell culture system to study the mechanisms of HBV DNA integration.
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Why is it important?
Hepatitis B virus DNA integration is now becoming more recognized as a key form of the virus, for both cancer formation and virus persistence. By developing this new model, we have found a way to start dissecting out how, when, and (hopefully) why HBV DNA integration occurs.
Read the Original
This page is a summary of: Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in anIn VitroInfection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles, Journal of Virology, February 2018, ASM Journals,
DOI: 10.1128/jvi.02007-17.
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