What is it about?
Cardiac progenitor cells transplantation improves cardiac function after myocardial infarction. This effect is largely mediated by secreted factors. Exosomes , secreted nano-sized membrane vesicles, act as intercellular carriers of proteins and nucleic acids including miRNA. We investigated the role of Exo in the paracrine secretion by human CPCs.
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Why is it important?
As a cell-free product, Exosomes have a potential for circumventing the limitations of cell therapy for cardiac repair.
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This page is a summary of: Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction, Cardiovascular Research, July 2014, European Society of Cardiology,
DOI: 10.1093/cvr/cvu167.
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