All Stories

  1. Effects of Dietary Sodium Modulation on Circulating Extracellular Vesicles

    Article • Hypertension, December 2025, Wolters Kluwer Health

    Prof. Lucio Barile

  2. To the Editor— DNA methylation and the potential role of extracellular vesicles in epilepsy-associated atrial fibrillation

    Article • Heart Rhythm, December 2025, Elsevier

    Prof. Lucio Barile

  3. Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation

    Article • Cell Communication and Signaling, November 2025, Springer Science + Business Media

    Prof. Lucio Barile

  4. Extracellular vesicle signature is associated with cardio-metabolic improvement after bariatric surgery

    Article • European Journal of Preventive Cardiology, September 2025, Oxford University Press (OUP)

    Prof. Lucio Barile

  5. Machine learning-assisted assessment of extracellular vesicles can monitor cellular rejection after heart transplant

    Article • Communications Medicine, July 2025, Springer Science + Business Media

    Prof. Lucio Barile

  6. Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

    Article • Immunity, April 2025, Elsevier

    Prof. Lucio Barile

  7. Unveiling the role of tyrosine kinases in doxorubicin-induced cardiotoxicity and beyond

    Article • Cardiovascular Research, March 2025, Oxford University Press (OUP)

    Prof. Lucio Barile

  8. Age- and sex-related variations in extracellular vesicle profiling for the assessment of cardiovascular risk: the EVaging index

    Article • npj Aging, December 2024, Springer Science + Business Media

    Prof. Lucio Barile

  9. miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues

    Article • Cardiovascular Research, November 2024, Oxford University Press (OUP)

    Prof. Lucio Barile

  10. Extracellular vesicles from II trimester human amniotic fluid as paracrine conveyors counteracting oxidative stress

    Article • Redox Biology, September 2024, Elsevier

    Prof. Lucio Barile

  11. A novel ionic model for matured and paced atrial-like human iPSC-CMs integrating I...

    Article • Computers in Biology and Medicine, September 2024, Elsevier

    Prof. Lucio Barile

  12. Extracellular vesicles selective capture by peptide-functionalized hollow fiber membranes

    Article • Journal of Colloid and Interface Science, August 2024, Elsevier

    Prof. Lucio Barile

  13. Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

    Article • Nature Aging, July 2024, Springer Science + Business Media

    Prof. Lucio Barile

  14. Evolving Strategies for Extracellular Vesicles as Future Cardiac Therapeutics: From Macro- to Nano-Applications

    Article • International Journal of Molecular Sciences, June 2024, MDPI AG

    Prof. Lucio Barile

  15. Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology

    Article • Journal of Thrombosis and Haemostasis, June 2024, Elsevier

    Prof. Lucio Barile

  16. Addressing Heterogeneity in Direct Analysis of Extracellular Vesicles and Their Analogs by Membrane Sensing Peptides as Pan‐Vesicular Affinity Probes

    Article • Advanced Science, May 2024, Wiley

    Prof. Lucio Barile

  17. Macrophage‐derived extracellular vesicles alter cardiac recovery and metabolism in a rat heart model of donation after circulatory death

    Article • Journal of Cellular and Molecular Medicine, April 2024, Wiley

    Prof. Lucio Barile

  18. Injury minimization after myocardial infarction: focus on extracellular vesicles

    Article • European Heart Journal, February 2024, Oxford University Press (OUP)

    Prof. Lucio Barile

  19. A novel ionic model for matured and paced atrial–like hiPSC–CMs integratingIKurandIKCacurrents

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Prof. Lucio Barile

  20. Impact of Isolation Methods on Extracellular Vesicle Functionality In Vitro and In Vivo

    Article • Advanced Biology, October 2023, Wiley

    Prof. Lucio Barile

  21. Intracoronary delivery of extracellular vesicles from human cardiac progenitor cells reduces infarct size in porcine acute myocardial infarction

    Article • European Heart Journal, October 2023, Oxford University Press (OUP)

    Prof. Lucio Barile

  22. Particle profiling of EV‐lipoprotein mixtures by AFM nanomechanical imaging

    Article • Journal of Extracellular Vesicles, October 2023, Wiley

    Prof. Lucio Barile

  23. Cardiomyocyte-targeting exosomes from sulforaphane-treated fibroblasts affords cardioprotection in infarcted rats

    Article • Journal of Translational Medicine, May 2023, Springer Science + Business Media

    Prof. Lucio Barile

  24. Extracellular Vesicles as Bridges Between Host Immune Cells and Graft Organ During Cellular Rejection

    Article • JACC Basic to Translational Science, May 2023, Elsevier

    Prof. Lucio Barile

  25. A dynamic clamping approach using in silico IK1 current for discrimination of chamber-specific hiPSC-derived cardiomyocytes

    Article • Communications Biology, March 2023, Springer Science + Business Media

    Prof. Lucio Barile

  26. Plasma Extracellular Vesicles as Liquid Biopsy to Unravel the Molecular Mechanisms of Cardiac Reverse Remodeling Following Resynchronization Therapy?

    Article • Journal of Clinical Medicine, January 2023, MDPI AG

    Prof. Lucio Barile

  27. Fndc5/irisin-enriched extracellular vesicles: a new hormonal relay in the regular race against vascular ageing

    Article • European Heart Journal, September 2022, Oxford University Press (OUP)

    Prof. Lucio Barile

  28. Identification of a serum and urine extracellular vesicle signature predicting renal outcome after kidney transplant

    Article • Nephrology Dialysis Transplantation, September 2022, Oxford University Press (OUP)

    Prof. Lucio Barile

  29. Myosins and MyomiR Network in Patients with Obstructive Hypertrophic Cardiomyopathy

    Article • Biomedicines, September 2022, MDPI AG

    Prof. Lucio Barile

  30. Risk stratification of patients with SARS-CoV-2 by tissue factor expression in circulating extracellular vesicles

    Article • Vascular Pharmacology, August 2022, Elsevier

    Prof. Lucio Barile

  31. Compositional profiling of EV-lipoprotein mixtures by AFM nanomechanical imaging

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Prof. Lucio Barile

  32. Investigating the Paracrine Role of Perinatal Derivatives: Human Amniotic Fluid Stem Cell-Extracellular Vesicles Show Promising Transient Potential for Cardiomyocyte Renewal

    Article • Frontiers in Bioengineering and Biotechnology, June 2022, Frontiers

    Prof. Lucio Barile

  33. Good reasons for targeting SARS-CoV-2 by engineered extracellular vesicles

    Article • Molecular Therapy — Methods & Clinical Development, June 2022, Elsevier

    Prof. Lucio Barile

  34. Supervised and unsupervised learning to define the cardiovascular risk of patients according to an extracellular vesicle molecular signature

    Article • Translational Research, June 2022, Elsevier

    Prof. Lucio Barile

  35. Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies

    Article • Brain, April 2022, Oxford University Press (OUP)

    Prof. Lucio Barile

  36. Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles

    Article • Cardiovascular Research, March 2022, Oxford University Press (OUP)

    Prof. Lucio Barile, Manuel Mayr

  37. Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging

    Article • Theranostics, January 2022, Ivyspring International Publisher

    Prof. Lucio Barile

  38. Extracellular Vesicle Surface Markers as a Diagnostic Tool in Transient Ischemic Attacks

    Article • Stroke, October 2021, Wolters Kluwer Health

    Prof. Lucio Barile

  39. Characterization of Circulating Extracellular Vesicle Surface Antigens in Patients With Primary Aldosteronism

    Article • Hypertension, September 2021, Wolters Kluwer Health

    Prof. Lucio Barile

  40. Correction to: Cardiac Graft Assessment in the Era of Machine Perfusion: Current and Future Biomarkers

    Article • Journal of the American Heart Association, June 2021, Wolters Kluwer Health

    Prof. Lucio Barile

  41. Circulating extracellular vesicles are endowed with enhanced procoagulant activity in SARS-CoV-2 infection

    Article • EBioMedicine, May 2021, Elsevier

    Prof. Lucio Barile

  42. Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab

    Article • Frontiers in Physiology, April 2021, Frontiers

    Prof. Lucio Barile

  43. Profiling Inflammatory Extracellular Vesicles in Plasma and Cerebrospinal Fluid: An Optimized Diagnostic Model for Parkinson’s Disease

    Article • Biomedicines, February 2021, MDPI AG

    Prof. Lucio Barile

  44. Cardiac Graft Assessment in the Era of Machine Perfusion: Current and Future Biomarkers

    Article • Journal of the American Heart Association, February 2021, Wolters Kluwer Health

    Prof. Lucio Barile

  45. A Changing Paradigm in Heart Transplantation: An Integrative Approach for Invasive and Non-Invasive Allograft Rejection Monitoring

    Article • Biomolecules, February 2021, MDPI AG

    Prof. Lucio Barile

  46. Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer

    Article • Communications Biology, January 2021, Springer Science + Business Media

    Prof. Lucio Barile

  47. An exosomal-carried short periostin isoform induces cardiomyocyte proliferation

    Article • Theranostics, January 2021, Ivyspring International Publisher

    Prof. Lucio Barile

  48. Insights into therapeutic products, preclinical research models and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC working group on cardiovascular regenerative and r...

    Article • Cardiovascular Research, December 2020, Oxford University Press (OUP)

    Prof. Lucio Barile

  49. Circulating extracellular vesicles as non-invasive biomarker of rejection in heart transplant

    Article • The Journal of Heart and Lung Transplantation, October 2020, Elsevier

    Prof. Lucio Barile

  50. Sphingolipid composition of circulating extracellular vesicles after myocardial ischemia

    Article • Scientific Reports, September 2020, Springer Science + Business Media

    Prof. Lucio Barile

  51. Role of cardiac progenitor cell-derived exosomes in a human model of ageing-induced cardiac dysfunction

    Article • Vascular Pharmacology, September 2020, Elsevier

    Prof. Lucio Barile

  52. Systemic delivery of cardiac progenitor cell-derived exosomes ameliorate cardiac dysfunction induced by cancer drugs

    Article • Vascular Pharmacology, September 2020, Elsevier

    Prof. Lucio Barile

  53. Immune profiling of plasma-derived extracellular vesicles identifies Parkinson disease

    Article • Neurology Neuroimmunology & Neuroinflammation, August 2020, Wolters Kluwer Health

    Prof. Lucio Barile

  54. An extracellular vesicle epitope profile is associated with acute myocardial infarction

    Article • Journal of Cellular and Molecular Medicine, July 2020, Wiley

    Prof. Lucio Barile

  55. The swan song of dying cells

    Article • Cardiovascular Research, June 2020, Oxford University Press (OUP)

    Prof. Lucio Barile

  56. Perioperative cardioprotection: back to bedside

    Article • Minerva Anestesiologica, April 2020, Edizioni Minerva Medica

    Prof. Lucio Barile

  57. Message in a Bottle: Upgrading Cardiac Repair into Rejuvenation

    Article • Cells, March 2020, MDPI AG

    Prof. Lucio Barile

  58. Mitochondrial and mitochondrial‐independent pathways of myocardial cell death during ischaemia and reperfusion injury

    Article • Journal of Cellular and Molecular Medicine, March 2020, Wiley

    Prof. Lucio Barile, Dr. Hector Cabrera-Fuentes, Professor Antigone Lazou

  59. Role of somatic cell sources in the maturation degree of human induced pluripotent stem cell-derived cardiomyocytes

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, March 2020, Elsevier

    Prof. Lucio Barile

  60. Ticagrelor Enhances Release of Anti-Hypoxic Cardiac Progenitor Cell-Derived Exosomes Through Increasing Cell Proliferation In Vitro

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Prof. Lucio Barile

  61. Human Induced Pluripotent Stem Cells Derived from a Cardiac Somatic Source: Insights for an In-Vitro Cardiomyocyte Platform

    Article • International Journal of Molecular Sciences, January 2020, MDPI AG

    Prof. Lucio Barile

  62. Inflammatory extracellular vesicles prompt heart dysfunction via TRL4-dependent NF-κB activation

    Article • Theranostics, January 2020, Ivyspring International Publisher

    Prof. Lucio Barile

  63. GMP-Grade Methods for Cardiac Progenitor Cells: Cell Bank Production and Quality Control

    Article • January 2020, Springer Science + Business Media

    Prof. Lucio Barile

  64. EXODEVICE: Continuous Perfusion Large Scale Exosome Cultivation Bioreactor

    Article • November 2019, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. Lucio Barile

  65. Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome

    Article • International Journal of Cardiology, July 2019, Elsevier

    Prof. Lucio Barile

  66. Flow Cytometric Analysis of Extracellular Vesicles from Cell-conditioned Media

    Article • Journal of Visualized Experiments, February 2019, MyJove Corporation

    Prof. Lucio Barile

  67. Flow Cytometric Analysis of Extracellular Vesicles from Cell-conditioned Media

    Article • Journal of Visualized Experiments, February 2019, MyJove Corporation

    Prof. Lucio Barile

  68. Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

    Article • International Journal of Molecular Sciences, January 2019, MDPI AG

    Prof. Lucio Barile

  69. Circulating blood cells and extracellular vesicles in acute cardioprotection

    Article • Cardiovascular Research, December 2018, Oxford University Press (OUP)

    Dr Sean Michael Davidson, Prof. Lucio Barile, Dr. Hector Cabrera-Fuentes, Professor Pasquale Pagliaro, Dr Henrique Girao

  70. Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

    Article • Frontiers in Physiology, August 2018, Frontiers

    Prof. Lucio Barile

  71. Notch pathway activation enhances cardiosphere in vitro expansion

    Article • August 2018, Wiley

    Prof. Lucio Barile

  72. ALDH1A3 Is the Key Isoform That Contributes to Aldehyde Dehydrogenase Activity and Affects in Vitro Proliferation in Cardiac Atrial Appendage Progenitor Cells

    Article • Frontiers in Cardiovascular Medicine, July 2018, Frontiers

    Prof. Lucio Barile

  73. The Bioactivities of Exosomes secreted by Cardiac Progenitor Cells

    Article • Cardiovascular Research, March 2018, Oxford University Press (OUP)

    Prof. Lucio Barile

  74. Beneficial effects of exosomes secreted by cardiac-derived progenitor cells and other cell types in myocardial ischemia

    Article • November 2017, AME Publishing Company

    Prof. Lucio Barile

  75. Angiogenic activity of exosomes isolated from human pericardial fluid

    Article • Biotarget, November 2017, AME Publishing Company

    Prof. Lucio Barile

  76. Exosomes: Therapy delivery tools and biomarkers of diseases

    Article • Pharmacology & Therapeutics, June 2017, Elsevier

    Prof. Lucio Barile

  77. Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity

    Article • Cardiovascular Research, April 2017, Oxford University Press (OUP)

    Prof. Lucio Barile

  78. First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential

    Article • Stem Cells Translational Medicine, March 2017, Wiley

    Prof. Lucio Barile

  79. Roles of exosomes in cardioprotection

    Article • European Heart Journal, July 2016, European Society of Cardiology

    Prof. Lucio Barile

  80. Induced Pluripotent Stem (IPS) Cells to Assess the Cardioprotective and Proangiogenic Activities of Exosomes Secreted by Human Cardiac Progenitor Cells

    Article • Biophysical Journal, February 2016, Elsevier

    Prof. Lucio Barile

  81. OUP accepted manuscript

    Article • EP Europace, January 2016, European Society of Cardiology

    Prof. Lucio Barile

  82. Epigenetic Regulation of Myocardial Homeostasis, Self-Regeneration and Senescence

    Article • Current Drug Targets, August 2015, Bentham Science Publishers

    Dr Vincenzo Lionetti, Prof. Lucio Barile

  83. Combination of mi RNA 499 and mi RNA 133 Exerts a Synergic Effect on Cardiac Differentiation

    Article • Stem Cells, March 2015, Oxford University Press (OUP)

    Prof. Lucio Barile, Dr Federica Pisano, Federica Pisano

  84. Exosomes for Intramyocardial Intercellular Communication

    Article • Stem Cells International, January 2015, Hindawi Publishing Corporation

    Prof. Lucio Barile

  85. Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of pulmonary hypertension

    Article • Cardiovascular Research, August 2014, European Society of Cardiology

    Prof. Lucio Barile

  86. Exosomes act as intercellular carriers of proteins and miRNAs

    Article • Cardiovascular Research, July 2014, European Society of Cardiology

    Prof. Lucio Barile

  87. Altered functional differentiation of mesoangioblasts in a genetic myopathy

    Article • Journal of Cellular and Molecular Medicine, February 2013, Wiley

    Prof. Lucio Barile

  88. Human Cardiospheres as a Source of Multipotent Stem and Progenitor Cells

    Article • Stem Cells International, January 2013, Wiley

    Prof. Lucio Barile

  89. Prometheus’s heart: what lies beneath

    Article • Journal of Cellular and Molecular Medicine, January 2012, Wiley

    Prof. Lucio Barile, Dr Vincenzo Lionetti

  90. Prevention of Myocardial Remodeling by Chronic INaL Blockade in Pulmonary Hypertension

    Article • Biophysical Journal, January 2012, Elsevier

    Prof. Lucio Barile

  91. Exosomes and Cardiomyocytes

    Article • Journal of Biomedicine and Biotechnology, January 2012, Wiley

    Prof. Lucio Barile

  92. Isolation and Expansion of Adult Cardiac Stem/Progenitor Cells in the Form of Cardiospheres from Human Cardiac Biopsies and Murine Hearts

    Article • January 2012, Springer Science + Business Media

    Prof. Lucio Barile

  93. Aberrant Functional Differentiation of Cardiac Precursors from a Dystrophic Mouse

    Article • Biophysical Journal, January 2012, Elsevier

    Prof. Lucio Barile

  94. Induced pluripotent stem cells: progress towards a biomedical application

    Article • Expert Review of Cardiovascular Therapy, October 2011, Taylor & Francis

    Prof. Lucio Barile

  95. A Brugada syndrome mutation (p.S216L) and its modulation by p.H558R polymorphism: standard and dynamic characterization

    Article • Cardiovascular Research, June 2011, European Society of Cardiology

    Prof. Lucio Barile

  96. Ferritin as a reporter gene for in vivo tracking of stem cells by 1.5-T cardiac MRI in a rat model of myocardial infarction

    Article • AJP Heart and Circulatory Physiology, June 2011, American Physiological Society

    Prof. Lucio Barile

  97. Cardiac Cell Therapy: The Next (Re)Generation

    Article • Stem Cell Reviews and Reports, March 2011, Springer Science + Business Media

    Prof. Lucio Barile

  98. Evidence for the Existence of Resident Cardiac Stem Cells

    Article • January 2011, Springer Science + Business Media

    Prof. Lucio Barile

  99. Bone marrow‐derived cells can acquire cardiac stem cells properties in damaged heart

    Article • Journal of Cellular and Molecular Medicine, January 2011, Wiley

    Prof. Lucio Barile

  100. Caffeine-induced Ca2+ signaling as an index of cardiac progenitor cells differentiation

    Article • Basic Research in Cardiology, July 2010, Springer Science + Business Media

    Prof. Lucio Barile

  101. Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application

    Article • Journal of Cellular and Molecular Medicine, May 2010, Wiley

    Prof. Lucio Barile, Professor Joost PG Sluijter

  102. c-kit cardiac progenitor cells: What is their potential?

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    Prof. Lucio Barile

  103. New Perspectives to Repair a Broken Heart

    Article • Cardiovascular & Hematological Agents in Medicinal Chemistry, April 2009, Bentham Science Publishers

    Prof. Lucio Barile

  104. Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields

    Article • Cardiovascular Research, February 2009, European Society of Cardiology

    Prof. Lucio Barile

  105. Stem cells in the heart: What's the buzz all about? Part 2: Arrhythmic risks and clinical studies

    Article • Heart Rhythm, June 2008, Elsevier

    Prof. Lucio Barile

  106. Stem cells in the heart: What's the buzz all about?—Part 1: Preclinical considerations

    Article • Heart Rhythm, May 2008, Elsevier

    Prof. Lucio Barile

  107. Ion Cyclotron Resonance as a Tool in Regenerative Medicine

    Article • Electromagnetic Biology and Medicine, January 2008, Taylor & Francis

    Prof. Lucio Barile

  108. Endogenous Cardiac Stem Cells

    Article • Progress in Cardiovascular Diseases, July 2007, Elsevier

    Prof. Lucio Barile

  109. Extremely low frequency magnetic field induces differentiation of the human cardiac stem cells

    Article • Journal of Molecular and Cellular Cardiology, June 2007, Elsevier

    Prof. Lucio Barile

  110. Cardiac stem cells can be generated in damaged heart from bone marrow-derived cells

    Article • Journal of Molecular and Cellular Cardiology, June 2007, Elsevier

    Prof. Lucio Barile

  111. The levels of GFP gene expression driven by regulatory regions of the mouse kit gene discriminate between HSC and progenitors

    Article • Blood Cells Molecules and Diseases, March 2007, Elsevier

    Prof. Lucio Barile

  112. Regenerative Potential of Cardiosphere-Derived Cells Expanded From Percutaneous Endomyocardial Biopsy Specimens

    Article • Circulation, February 2007, Wolters Kluwer Health

    Prof. Lucio Barile

  113. Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration

    Article • Nature Clinical Practice Neurology, February 2007, Springer Science + Business Media

    Prof. Lucio Barile

  114. Cyclic Nucleotides and Neuroblastoma Differentiation

    Article • Nucleosides Nucleotides & Nucleic Acids, December 2004, Taylor & Francis

    Prof. Lucio Barile

  115. Potential Role of Mycophenolate Mofetil in the Management of Neuroblastoma Patients

    Article • Nucleosides Nucleotides & Nucleic Acids, December 2004, Taylor & Francis

    Prof. Lucio Barile

  116. Low levels of mycophenolic acid induce differentiation of human neuroblastoma cell lines

    Article • International Journal of Cancer, August 2004, Wiley

    Prof. Lucio Barile