What is it about?
The nanostructure pharmaceutical formulations (NPF) which contains testosterone undecanoate (TU) been used in life science as parent compound delivery systems for therapeutic, but and been used to enhance the performance in sport, so it is a significant substance for public health and nutritional supplements. In most Pharmacopoeias testosterone is described as an ester of some lower acids (often propionate). The aim of this study is to determine purity of the parent compound by chromatography and absorption spectrum in the frame of middle infrared.
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Why is it important?
Chemical structure of undecanoate was prepared and used in order to achieve a better absorption. This is explained by increased lipophilicity of undecanoate. Due to its lipophilic character, TU is soluble in non–polar solvents but shows a satisfactory solubility in absolute ethanol. Based on the molecular structure, a moderate absorption in the frame of UV with a maximum absorption at a not too high wave-length can be predicted. Maximum absorption occurs in a spectral region in which usual ingredients do not present significant interference.
Perspectives
This research highlights the role of the analytical methods in assessing the quality of the parent compound, by using some techniques such as chromatographic, spectroscopic and spectrophotometric dosing, their corresponding methods that have been applied in the analysis of NPF
habilitated doctor, chemist Monica BUTNARIU
University of Life Sciences "King Mihai I" from Timisoara
Read the Original
This page is a summary of: Spectrophotometric and chromatographic strategies for exploring of the nanostructure pharmaceutical formulations which contains testosterone undecanoate, Scientific Reports, February 2020, Springer Science + Business Media,
DOI: 10.1038/s41598-020-60657-4.
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