What is it about?
A combination of relatively rigid macrocycle of the studied calixarenes and their long flexible substituents capable of H-bonding gives almost infinite number of polymorphs depending on the preparation procedure. The hydrophilicity of one of these calixarenes can be switched on/off by consecutive treatment with different organic solvent vapors and drying, which gives hydrophilic or hydrophobic polymorph.
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Why is it important?
The results give insight into the structural factors of polymorphophism, which can be extrapolated to pharmaceuticals.
Perspectives
The efficient procedures of polymorph screening can be elaborated giving discovery of more polymorphs than crystallization from melts and solutions
Valery Gorbatchuk
Kazan Federal University
Read the Original
This page is a summary of: Smart Polymorphism of Thiacalix[4]arene with Long-Chain Amide Containing Substituents, Crystal Growth & Design, May 2017, American Chemical Society (ACS),
DOI: 10.1021/acs.cgd.7b00463.
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