What is it about?
A fundamental metabolic feature of cancerous tissues is high glucose consumption.
Featured Image
Why is it important?
The rate of glucose consumption in a cancer cell can be 10–15 times higher than in normal cells. Isolation and cultivation of tumor cells in vitro highlight properties that are associated with intensive glucose utilization, the presence of minimal oxidative metabolism, an increase in lactate concentrations in the culture medium and a reduced rate of oxygen consumption. Although glycolysis is suggested as a general feature of malignant cells and recently identified as a possible contributing factor to tumor progression, several studies highlight distinct metabolic characteristics in some tumors, including a relative decrease in avidity compared to glucose and/or a glutamine dependency of lactate and even proliferative tumor cells.
Perspectives
The aim of this review is to determine the particularities in the energy metabolism of cancer cells, focusing on the main nutritional substrates, such as glucose and glutamine, evaluating lactate dehydrogenase as a potential marker of malignancy and estimating activators and inhibitors in cancer treatment.
habilitated doctor, chemist Monica BUTNARIU
University of Life Sciences "King Mihai I" from Timisoara
Read the Original
This page is a summary of: Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis, Archives of Toxicology, March 2021, Springer Science + Business Media,
DOI: 10.1007/s00204-021-02974-9.
You can read the full text:
Contributors
The following have contributed to this page
