Organ system view of the hepatic innate immunity in HCV infection

What is it about?

Reviews our current understanding of hepatic antiviral immunity at organ system level.

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Why is it important?

The eradication of viral pathogen requires well coordinated immune activation that involves both parenchymal and non-parenchymal cells of the liver.

Perspectives

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Towards the development of definitive protection against hepatitis C virus infection, it is critical to advance our understanding on how the infected hepatocytes (parenchymal cell) and non-parenchymal (such as hepatic macrophage) coordinate the immune network within the liver.

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