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Chronic ulcers represent a major health problem in diabetic patients resulting in pain and discomfort. Conventional therapy does not guarantee adequate wound repair. In diabetes, impaired healing is partly due to poor endothelial progenitor cells mobilisation and homing, with altered levels of the chemokine stromal-derived factor-1 (SDF-1) at the wound site. Investigators demonstrated that topical administration of adipose tissue derived stromal cells improves impaired wound healing in diabetic mice. In addition, presented data suggest that concomitant genetic manipulation of transplanted adipose tissue stromal cells designed to promote overexpression of SDF-1 may further improve diabetic impaired wound healing.
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This page is a summary of: Enhanced Healing of Diabetic Wounds by Topical Administration of Adipose Tissue-Derived Stromal Cells Overexpressing Stromal-Derived Factor-1: Biodistribution and Engraftment Analysis by Bioluminescent Imaging, Stem Cells International, January 2011, Hindawi Publishing Corporation,
DOI: 10.4061/2011/304562.
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