What is it about?
Childhood obesity progresses to metabolic disturbances via low-grade inflammation. Identifying novel molecules that reflect the activity of the immune responses is critical in understanding its underlying pathogenesis. To the best of our knowledge, the influence of these two CHIT1 gene variants on the plasma CHIT1 activity in children with obesity has not been investigated and reported. We hypothesize that plasma CHIT1 activity, as a marker of low-grade systemic inflammation, might be elevated in children with high levels of obesity. The current study.s objectives were to assess in children: (i) The variability of CHIT1 plasma activity by weight status based on BMI-for-age z scores; (ii) The association of dup24 and G102S polymorphism with plasma CHIT1 activity in patients with different levels of obesity by analyzing the observed difference in enzymatic activity between genotype subgroups and the effect of the Bussink et al. [34] correction method; (iii) The contribution of dup24, G102S polymorphism, and BMI-for-age z score to the variation of CHIT1 plasma activity.
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Why is it important?
Circulating CHIT1 might be an accurate indicator of inflammation in children with obesity. Its role should be validated in a larger cohort, and the effect of the dup24 and G102S variants on the CHIT1 activity should also be considered.
Perspectives
Our results showed that CHIT1 plasma activity increases with the obesity level in our pediatric population without metabolic complications. More specifically, the elevated CHIT1 circulating levels are significantly higher in children with extreme obesity than in children with overweight. The variation in logCHIT1 circulating levels is positively linearly explained by increasing the BMI-for-age z score with an amplified effect when covariates (dup24, G102S, age, gender, and time since weight gain) are controlled. Validation of the present findings by future investigations with a larger cohort is necessary to acknowledge the effect of the 24-base pair duplication and G102S polymorphism of CHIT1 gene when evaluating CHIT1 activity as an inflammatory marker in children with obesity
PhD, MD racataianu nicoleta
UMF Iuliu Hatieganu Cluj-Napoca Romania
Read the Original
This page is a summary of: Evaluation of Circulating Chitotriosidase Activity in Children with Obesity, Journal of Clinical Medicine, June 2022, MDPI AG,
DOI: 10.3390/jcm11133634.
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