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The study presents a novel view of the impact of acute alcohol intake on bone marrow and spleen cell proliferation in a transgenic mouse model. Acute alcohol consumption in mice is associated with a reduction in physiological proliferation of bone marrow progenitor cells. These data are in agreement with a previously established cytotoxic effect on hematopoietic stem cells exerted by aldehydes produced by both ethanol and methanol metabolism. Pharmacological treatment with substances interfering with ethanol metabolism, reducing acetaldehyde production, partially restores the physiological cell proliferation rate. Collectively, these data demonstrate that acute alcohol administration affects bone marrow cell proliferation and further support the notion that aldehyde dehydrogenase (ALDH) might represent a druggable target for protection of alcohol and aldeshydes' endogenous production and de-toxification.
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This page is a summary of: Reduction of Cell Proliferation by Acute C2H6O Exposure, Cancers, October 2021, MDPI AG,
DOI: 10.3390/cancers13194999.
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Reduction of Cell Proliferation by Acute C2H6O Exposure
Open access version
Stem cells under the infuence of alcohol: effects of ethanol consumption on stem/progenitor cells
Cellular and Molecular Life Sciences (2019) 76, 231–244 https://doi.org/10.1007/s00018-018-2931-8
Reduction of Cell Proliferation by Acute C2H6O Exposure
Free PMC version
Special Issue "Alcohol Use and Cancer Risk"
A special issue of Cancers (ISSN 2072-6694).
Hematology Week
Research from IRCCS-Regina Elena National Cancer Institute Has Provided New Data on Cancer Research (Reduction of Cell Proliferation by Acute C2H6O Exposure)
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