What is it about?
The goal of this work is to test whether the standard nitrocellulose analytical strip in a lateral flow assay (LFA) can be replaced by a commercially available cellulose paper strip without a significant loss of performance. To do so, we present a LFA for the quantitative, fluorescence-based detection of the cardiac biomarker troponin I (cTnI) that features an analytical strip made of cellulose filter paper.
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Why is it important?
The current relevance and impact of LFA in the diagnostics arena could significantly expand if drawbacks like low sensitivity, low specificity, and lack of quantitation can be overcome. Significant research efforts are thus being devoted to bringing the overall performance of LFAs close to that afforded by standard laboratory tests like ELISA and PCR.
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This page is a summary of: A Cellulose Paper-Based Fluorescent Lateral Flow Immunoassay for the Quantitative Detection of Cardiac Troponin I, Biosensors, February 2021, MDPI AG,
DOI: 10.3390/bios11020049.
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