Porous Si-Ca-P Monophasic Ceramic on Osteogenesis-Related Gene Expression

What is it about?

This work evaluates in vitro the influence of a new biocompatible porous Si-Ca-P monophasic (7CaO·P2O5·2SiO2) ceramic on the cellular metabolic activity, morphology and osteogenic differentiation of adult human mesenchymal stem cells (ahMSCs) cultured in basal growth medium and under osteogenic inductive medium.

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Why is it important?

We could check osteogenic differentiation in ahMSCs growing under the influence of Si-Ca-P monophasic ceramics itself, but especially when growth medium was replaced by osteogenic medium in the culture conditions. These results allowed us to conclude that the new Si-Ca-P monophasic scaffold greatly enhanced ahMSCs proliferation and osteogenic differentiation; therefore, it may be considered to be employed as a new bone graft substitute or scaffold for bone tissue engineering.