What is it about?
We investigated the association between fosfomycin and temocillin on 100 clinical isolates of KPC-producing K. pneumoniae. The results demonstrated synergistic activity in 91% of the isolates. Subsequently, we assessed the effect on Galleria mellonella larvae using five genetically different KPC-Kp isolates. The addition of fosfomycin to temocillin increased Galleria mellonella larvae survival from 73 to 97% (+∆ 32%; isolate 1), from 93 to 100% (+∆ 7%; isolate 2), from 63 to 86% (+∆ 36%; isolate 3), from 63 to 90% (+∆ 42%; isolate 4), and from 93 to 97% (+∆ 4%; isolate 10).
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Why is it important?
Among the temocillin-resistant KPC-producing K. pneumoniae isolates (24 isolates), the addition of fosfomycin reduced temocillin MIC values below the resistance breakpoint in all isolates except one. Temocillin combined with fosfomycin emerges as a promising combination against KPC-producing K. pneumoniae, warranting further clinical evaluation.
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This page is a summary of: Synergistic Activity of Temocillin and Fosfomycin Combination against KPC-Producing Klebsiella pneumoniae Clinical Isolates, Antibiotics, June 2024, MDPI AG,
DOI: 10.3390/antibiotics13060526.
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