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We performed a systematic review on in vitro studies reporting A. baumannii resistances against sulbactam/durlobactam (9754 tested isolates). Overall, 2.3% of A. baumannii were resistant to sulbactam/durlobactam, and this percentage rose to 3.4% among CRAB subgroups and to 3.7% among colistin-resistant strains. Resistance was 100% among metallo β-lactamase-producing strains. Overall, in 12.5% of cases, sulbactam/durlobactam resistance was associated with the production of NDM-1, in 31.7% of cases with the substitutions in the PBP3 determinants, and in the remaining cases the resistance mechanism was unknown. In conclusion, A. baumannii resistance towards sulbactam/durlobactam is limited, except for MBL-producing strains.

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This page is a summary of: Acinetobacter baumannii Resistance to Sulbactam/Durlobactam: A Systematic Review, Antibiotics, December 2022, MDPI AG,
DOI: 10.3390/antibiotics11121793.
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