What is it about?

Coronavirus disease 2019 (COVID-19) characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created serious concerns about its potential adverse effects. There are limited data on clinical, radiological, and neonatal outcomes of pregnant women with COVID-19 pneumonia. This study aimed to assess clinical manifestations and neonatal outcomes of pregnant women with COVID-19.

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Why is it important?

Our study findings show that the clinical, laboratory and radiological characteristics of pregnant women with COVID-19 were similar to those of the general populations. The possibility of vertical transmission cannot be ignored but C-section should not be routinely recommended anymore according to latest evidences and, in any case, decisions should be taken after proper discussion with the family. Future studies are needed to confirm or refute these findings with a larger number of sample sizes and a long-term follow-up period.

Perspectives

Coronaviruses (CoVs) are a single positive-stranded RNA virus that causes infection of humans. SARS-CoV-2 is one of the coronavirus species that emerged in China and which has rapidly spread throughout the world in 2020. The pandemic of SARS-CoV-2 infection has already created public health threats resulting in a significant proportion of deaths. Pregnant women are more susceptible to respiratory pathogens and pneumonia and are at risk of adverse obstetrical outcomes like the pre-mature rupture of membranes (PROM), pre-term labor (PTL), and neonatal death. This is due to the immunosuppressive state as well as physiological differences (e.g., diaphragm elevation, increased oxygen consumption, and oedema of respiratory tract mucosa) which often leads to severe hypoxia. Previous studies reported that the mortality rate for pregnant women with influenza (1918–1919 pandemic) was 37%; the rate of mortality was even higher (~50%) in patients who were in their 3rd-trimester of pregnancy

Md.Mohaimenul Islam
Taipei Medical University

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This page is a summary of: Clinical Characteristics and Neonatal Outcomes of Pregnant Patients With COVID-19: A Systematic Review, Frontiers in Medicine, December 2020, Frontiers,
DOI: 10.3389/fmed.2020.573468.
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