What is it about?
This is a retrospective study of guideline-directed management with invasive procedures and medical treatment of myocardial infarction in patients with and without chronic kidney disease from 2010-2022. Chronic kidney disease is present in >30% of patients with acute myocardial infarction.
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Why is it important?
Chronic kidney disease is associated with a poor prognosis in patients with acute myocardial infarction, possibly partly due to undertreatment. In this study, chronic kidney disease was associated with lower rate of guideline-directed management and worse prognosis. However, uptake of guideline-directed management increased, and prognosis improved in both patients with and wihtout chronic kidney disease during the study period
Perspectives
Patients with chronic kidney disease have been systematically excluded from randomized clinical trials on treatment of acute myocardial infarction, resulting in uncertain treatment benefit. In this study, guideline-directed management was associated with an improved prognosis. However, randomized clinical trials are needed to further investigate treatment benefit in patients with chronic kidney disease and acute myocardial infarction.
Ellen Ballegaard
Read the Original
This page is a summary of: Acute myocardial infarction and chronic kidney disease: A nationwide cohort study on management and outcomes from 2010-2022, Clinical Journal of the American Society of Nephrology, July 2024, Wolters Kluwer Health,
DOI: 10.2215/cjn.0000000000000519.
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