Hypothyroidism And Brain Development

What is it about?

Hypothyroidism during the development caused the following (1) Reduced the myelination of neuronal axons; (2) altered the dendritic structure cortical pyramidal cells; (3) reduced the Purkinje cell dendritic arborizations, the parallel fiber outgrowth and migration of the granule cells, and the number of granule cells; (4) diminished the synaptogenesis; (5) altered the molecular, morphological and functional actions of hippocampus; and (6) delayed the hypothalamic-pituitary development

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Why is it important?

THs deficiency during the early developmental period might delay the neuronal differentiation, decrease the neuronal connectivity, impair the motor skills and visual processing, and cause severe and permanent brain damage or mental retardation. these adverse effects may facilitate directly by a loss of the maternal THs contribution to the fetus or indirectly by the metabolic impairment of gestation, or both.

Perspectives