What is it about?
Mixing/ complexting cyclodextrin to insoluble or poorly soluble drug like racecadotril to form the complex may lead to more soluble form of the drug which may lead to the better entry into the gastric fluid and hence the overall amount to the biological system shall reported to be improved. Types of cyclodextrin may play a role in solubility, dissolution and permeability enhancement.
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Why is it important?
Improving water solubility of drugs is always beneficial with respect to the solubilization of drug in the aqueous based gastro-intestinal fluid which in turn may lead to better drug absorption and hence the better bioavailability. Higher the bioavailability of drug, more effective it shall be in lesser amount which shall not only be cost effective but also be associated with the least adverse effects and hence safer due to lesser amount of drug exposed to the peripheral distribution).
Perspectives
The present article give a good insight to the field of research in solubility and dissolution enhancement. The critical analysis of method of preparation and the ratio of drug and cyclodextrin has been studied with respect to the performance of complex in solubility and dissolution enhancement.
Dr AJAY SEMALTY
H.N.B. Garhwal University Srinagar Garhwal
Read the Original
This page is a summary of: Cyclodextrin Inclusion Complex of Racecadotril: Effect of Drug-β- Cyclodextrin Ratio and the Method of Complexation, Current Drug Discovery Technologies, May 2014, Bentham Science Publishers,
DOI: 10.2174/15701638113106660043.
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