What is it about?
The metabolic enzyme glutamate dehydrogenase, present in helminth viable larval cyst, mediates a novel PGE2-IL-10 axis of regulatory T cell induction, potentially controlling brain inflammation. PGE2 and IL-10 are induced by glutamate dehydrogenase from tolerogenic-like monocytes and microglia and act on G protein-coupled receptors EP2 and EP4 and IL-10 receptor. The absence of glutamate dehydrogenase in degenerated larval cyst products promotes inflammatory non-phagocytic microglia expressing the pro-epileptic factor TGF-ß.
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Why is it important?
Harnessing the novel PGE2 -IL-10 axis and targeting TGF-ß signaling may offer an important therapeutic strategy in inflammatory epilepsy and NCC.
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This page is a summary of: Helminthic dehydrogenase drives PGE
2
and IL‐10 production in monocytes to potentiate Treg induction, EMBO Reports, March 2022, EMBO,
DOI: 10.15252/embr.202154096.
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