What is it about?
Increase of oral absorption of an oily drug (AL-294) by an emulsion dosage fom.
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Why is it important?
AL-294 is a prodrug of AL-294 acid ethyl ester and has a lipophilic characteristic (oil). Therefore, dissolution is rate-limiting to the oral absorption of this compound. An emlusion dosage form can increase the oral absorption of an oily drug, depending on the size of emulsion.
Perspectives
Based on this study, a self-emulsifying dosafe form of AL-294 was developed (Chem Pharm Bull. 38:2792-6 (1990)).
Dr Katsumi Iga
Doshisha Joshi Daigaku
Read the Original
This page is a summary of: Effects of physiological factors on the bioavailability of ethyl 2-chloro-3-(4-(2-methyl-2-phenyl-propyloxy) phenyl) propionate in an emulsion in rats., Chemical and Pharmaceutical Bulletin, January 1990, Pharmaceutical Society of Japan,
DOI: 10.1248/cpb.38.2801.
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