Ionic-doped calcium phosphates and silk fibroin composites for bone tissue engineering

What is it about?

Functional scaffolding materials such as biopolymers and bioresorbable fillers have gained particular attention, owing to their ability to promote cell adhesion, proliferation, and extracellular matrix production, which promote new bone growth. Here, we present novel biofunctional scaffolds for bone regeneration composed of silk fibroin (SF) and β-tricalcium phosphate (β-TCP) and incorporating Sr, Zn, and Mn.

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Why is it important?

Ionic-doping of the composites which increases the production of growth factors like bone morphogenetic protein-2 and vascular endothelial growth factor, and can improve the mechanical properties of the scaffolds by modifying the lattice structure, microstructure, crystallinity, and dissolution rate of the CaPs.