Performance of the 47-Kilodalton Membrane Protein versus DNA Polymerase I Genes for Detection of Treponema pallidum by PCR in Ulcers

What is it about?

This study has compared the diagnostic performance of the two targets currently used to amplify Treponema pallidum by PCR: 47kDa protein membrane versus polymerase I gene. We demonstrated that the two targets provide similar accuracy and could be univocally used in routine.

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Why is it important?

This is the first study providing a comparison of the diagnostic performance of the two PCRs used in the diagnosis of syphilis on the same samples. This comparison was done on paired samples from a large collection of swabs (n=272). The findings of this study showed the two targets provide the same diagnostic performance and have an almost perfect agreements.