Structural basis for substrate selection by the translocation and assembly module of the β-barrel assembly machinery

What is it about?

The assembly of proteins into the outer membranes is a key process in bacteria. The folding and assembly of these proteins is mediated by a system referred to as the beta-barrel assembly machinery (BAM) which includes two related proteins: BamA in the BAM complex, TamA in the TAM. We sought to distinguish these two, ostensibly similar proteins, and to understand why both have had to be conserved through evolution.

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