Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reaction in vivo.

What is it about?

The aim of this study was to compare the influence of the physical–chemical properties of synthetic hydroxyapatite (HA) and biphasic commercial materials on the biological behavior of study materials through material characterization and SEM analysis before and after application in rabbit tibias

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Why is it important?

4Bone: Pores between 300 lm and 100 lm with intra- and interparticle spaces. Ossceram show also interparticle and intraparticle pores, between 100 lm and 26 lm, but the proportion of interparticles in the 4Bone is clearly minor than in the Ossceram. Related with pure HA, Group III has the greatest porosity (69.3%). For Group I, the intraparticle pores (0.71 lm) are about 8 times larger than those of the other two samples. The analysis of the images of in vivo SEM shown as biphasic groups has presented a more gradual resorption of the material. Conclusion: HA-based biomaterials, both pure and biphasic, are an effective means for bone regeneration processes; of these, materials with higher initial and secondary porosimetry allow greater cell colonization and therefore more effective substitution by new bone. The two-phase materials have a higher ion release to the environment in the early stages and thus allow greater colonization by collagen fibers that can be matured into new bone.