Decreasing Bladder Cancer Survival: Insights from a Population-Based Registry

What is it about?

This study aimed to explore the causes of the decrease in bladder cancer survival that has occurred over the past four decades. Data from the South Australian Cancer Registry were extracted to explore changes in incidence and survival among a total of 8356 patients diagnosed with ≥pT1 disease. The age-standardized incidence of invasive bladder cancer decreased from 7.20 cases per 100 000 people in 1977 to 5.85 cases per 100 000 in 2020. Overall survival from invasive bladder cancer decreased over the study period. The decreasing invasive bladder cancer survival resulted from an increase in mean age at diagnosis, from 68 years between 1977 and 1980 to 76 years between 2015 and 2020. Age at diagnosis increased from 68 to 76 years over the study period, perhaps due to reduced exposure to carcinogens. The decreasing invasive bladder cancer survival resulted from an increase in mean age at diagnosis.

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Why is it important?

This research is important because it aims to explore the causes of the decrease in bladder cancer survival that has occurred over the past four decades. The study provides insights into the factors contributing to the decline in survival rates and highlights the need for new treatments to address this issue. Key Takeaways: 1. Invasive bladder cancer age-standardized incidence decreased from 7.20 cases per 100 000 people in 1977 to 5.85 cases per 100 000 in 2020. 2. Overall survival from invasive bladder cancer decreased over the study period, during which non-invasive bladder cancer survival remained stable. 3. The decreasing invasive bladder cancer survival resulted from an increase in mean age at diagnosis, from 68 years between 1977 and 1980 to 76 years between 2015 and 2020. 4. Age at diagnosis increased from 68 to 76 years over the study period, perhaps due to reduced exposure to carcinogens. 5. Age was inversely correlated to bladder cancer survival, and Cox proportional hazard modelling showed that the largest impact on decreasing survival over the study period was increasing age at diagnosis.