Effects of transforming growth factor-β1 treatment on muscle regeneration and adipogenesis in glycerol-injured muscle

What is it about?

We hypothesized that treatment with TGF-β1 " potent profibrotic cytokine" might enhance collagen deposition at early stages following glycerol-induced injury. We investigated the effects of exogenous TGF-b1 on muscle regeneration and adipogenesis in the glycerol-injured muscle of normal mice

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Why is it important?

Combination of TGF-β1 with glycerol might be an alternative to enhance muscle fibrosis for future studies.

Perspectives

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The combination of TGF-β1 with glycerol-induced injury provides a simple model to enhance muscle fibrosis which may help fibrosis-related research and development of anti-fibrosis therapeutics.

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