Myocardial infarction is associated with CCR7 polymorphism

C-C chemokine receptor type 7 and C-C motif chemokine 19 polymorphism and angiographic patterns of coronary arteryatherosclerosis

INTRODUCTION. The aim of the study was to search for association between polymorphisms in the genes for C-C chemokine receptor type 7 and C-C motif chemokine 19 and angiographic patterns of coronary artery atherosclerosis or myocardial infarction risk in Polish population. METHODS. 300 patients with chronic stable coronary artery disease undergoing coronarography were genotyped by RFLP method and reverse dot blot hybridization. Single variable analysis for genotype-phenotype association involved chi-square test for additive, dominant and recessive model of inheritance, Fisher’s exact test, Cochran-Armitage trend test. Multivariate analysis involved linear regression and logistic regression RESULTS: Allele A rs17708087 frequency in patient who underwent myocardial infarction was significantly higher (75,5%) than in control group (59%, p=0,01). AA homozygotes versus other genotype carriers presented over two-fold increased risk of myocardial infarction (OR 2,13, CI 1,13-3,86). No correlation was found between CCR7, CCL19 polymorphisms and angiographic patterns of coronary artery atherosclerosis. CONCLUSIONS: The results of the study suggest that polymorphism rs17708087 may be potentially a risk factor of myocardial infarction in Polish population. Risk prediction models for coronary artery disease with rs17708087 require further research.