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Endothelial cells are exposed to an acidic pH in a variety of pathological and physiological conditions including ischaemia. Authors provided evidences that via inhibition of the chemokine receptor CXCR4 expression and function, acidosis may prepare/program endothelial cells to the neoangiogenic response to ischaemia.

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This page is a summary of: Role of HIF-1α in proton-mediated CXCR4 down-regulation in endothelial cells, Cardiovascular Research, December 2009, European Society of Cardiology,
DOI: 10.1093/cvr/cvp393.
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