What is it about?
Avian genome editing has relied on utilization of primordial germ cells (PGCs) to generate genome-edited offspring in the next generation. In this study, we provide a new method for genome editing in different avian species. We showed that the injection of adenovirus containing the CRISPR/Cas9 system into blastoderms of freshly laid eggs can induce genome editing in the blastodermal PGCs and generate genome-edited chicken and duck offspring.
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Why is it important?
The adenovirus-mediated method could allow more researchers to conduct genome editing in various avian species, thereby accelerating the avian genome editing-related research, and providing potential benefits to the agricultural industry.
Read the Original
This page is a summary of: Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing, Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2214344119.
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