What is it about?
The links are the generalization of knots, i.e. they are entangled set of circles. Such complex topology as it turned out can be also identified in proteins. In particular, there are three types of links in proteins. These have a great impact on the stability of proteins and are strictly conserved by evolution.
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Why is it important?
The existence of links in proteins explains, how topology increases the stability of proteins. This can be used in the design of superstable proteins.
Perspectives
The work describes for the first time existence of links in proteins. We also undertake the quest for the Borromean rings in proteins. In particular we show, that there is no Borromean ring, however, there is a structure which is "1/3" of Borromean rings, which also has some impact on the stability of such structures.
Pawel Dabrowski-Tumanski
University of Warsaw
Read the Original
This page is a summary of: Topological knots and links in proteins, Proceedings of the National Academy of Sciences, March 2017, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.1615862114.
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