The percentage flap survival area was significantly higher in the adipose stem cells treated flaps

What is it about?

Ischemia-reperfusion (I/R) injury is inevitable during free tissue transfers. When the period of ischemia exceeds the tissue tolerance, it causes necrosis and flap failure. The aim of this study was to investigate the effects of adipose-derived stem cells (ASCs) embedded in a collagen type I scaffold on the survival of free skin flaps to counteract I/R injury.

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Why is it important?

Subcutaneous administration of adipose-derived stem cells embedded on a collagen type I scaffold reduces tissue damage after I/R injury in microvascular free flaps.