What is it about?
Paper shows how two polymorphs of tolazamide behave at high pressure using single crystal X-ray diffraction. Gas phase and periodic DFT study helps to rationalize why there is no phase transitions under pressure despite difference in densities of two forms of tolazamide
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Why is it important?
High-pressure behavior of polymorphic compounds helps to understand the nature of polymorphism and crystal structures
Perspectives
Low-temperature study and in-depth analysis of reasons for possible phase transitions are in process now. Several interesting ideas will be tested at this all-round studied system
Dr Denis A. Rychkov
Novosibirsk State University, ISSC SB RAS
Read the Original
This page is a summary of: Effect of pressure on two polymorphs of tolazamide: why no interconversion?, CrystEngComm, January 2017, Royal Society of Chemistry,
DOI: 10.1039/c6ce02527g.
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