What is it about?
You probably know someone with a food allergy. Its incidence is around 1% and rising, especially in children. Measurement of a certain type of antibodies (IgEs) in blood serum is among the diagnostic tests that are currently used to determine if a patient is allergic to a given food or not. The current format of the analysis gives incomplete information, however. Our team is working to develop a new method for separating the antibodies based on specific components of the allergen. This paper reports on a key advancement in that project where a peptide and a carbohydrate present in peanut proteins is used to quantify the antibodies in patient serum samples.
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Why is it important?
A detector that separates all the IgEs in serum based on what those antibodies bind to will be value for helping doctors diagnose patients with a specific food allergy. Additionally, it will provide a valuable tool to immunologists for piecing together the fundamental aspects of how these allergies arise.
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Read the Original
This page is a summary of: Ultrasensitive carbohydrate-peptide SPR imaging microarray for diagnosing IgE mediated peanut allergy, The Analyst, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c4an01544d.
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