What is it about?
In this study we report that a novel chemical probe is able to prevent neuronal cell death while reducing microglia phagocytosis that was induced by amyloid-β, a peptide crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. This probe also suppresses the expression of inflammatory mediators in microglia induced by amyloid-β.
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Why is it important?
Taken together, these results suggest this molecule emerges as a potential new therapeutic strategy for Alzheimer’s disease.
Perspectives
This work opens a new avenue regarding the identification of new molecular targets involved in the etiology of Alzheimer's disease
Rui Moreira
Research Institute for Medicines (iMed.ULisboa), School of Pharmacy, University of Lisbon
Read the Original
This page is a summary of: Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?, ACS Chemical Neuroscience, October 2016, American Chemical Society (ACS),
DOI: 10.1021/acschemneuro.6b00169.
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