What is it about?
Controlling local and systemic factors during the wound-healing process, including inflammation, proliferation, and maturation, can play a key role in effective wound healing. It is worth taking advantage of matrix- or scaffold-based therapeutic approaches. Herein, a gold nanorod (GNR)-incorporated poly(lactic-co-glycolic acid) (PLGA)/poly(caprolactone) (PCL) scaffold was developed to improve the wound-healing effect by controlling heat shock protein (HSP70) via external light stimulation.
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Why is it important?
The GNR-incorporated scaffold showed no harmful effects on the cells and could stimulate cell proliferation in vitro by generating mild heat generation in a timely manner with laser irradiation. A GNR-incorporated scaffold attached to the wound of mice effectively increased the local temperature to 40 °C after laser irradiation, more effectively promoting HSP70 expression and the wound-healing process compared to that of conventional dressing- and scaffold-treated mice.
Perspectives
The GNR-incorporated scaffold and timely control HSP70 expression approach can be used as a promising wound-healing strategy for improving the therapeutic effect.
Dr. Sitansu Sekhar Nanda
Myongji University
Read the Original
This page is a summary of: Gold-Nanorod-Based Scaffolds for Wound-Healing Applications, ACS Applied Nano Materials, June 2022, American Chemical Society (ACS),
DOI: 10.1021/acsanm.2c02230.
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