What is it about?
Herein, a method is proposed to evaluate the accuracy of the single-cell electrical model with cell-sized unilamellar liposomes synthesized through double emulsion droplet microfluidics. The influence of three key dimension parameters (i.e., the measurement channel width w, height h, and electrode gap g) in the single-cell electrical model were evaluated respectively through experiment.
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Photo by Fulvio Ciccolo on Unsplash
Why is it important?
The accuracy of the spherical single-shell electrical model widely used in IFC has not been well evaluated, due to the lack of reliable and reproducible single-shell model particles with true-value electrical parameters as benchmarks. This work fills the gap.
Perspectives
The results in this study provide a solid guideline for the design of IFC measurement system. It is envisioned that this method can advance further improvement of IFC and accurate electrical characterization of single cells.
Professor Wenhui Wang
Tsinghua University
Read the Original
This page is a summary of: Evaluating the Accuracy of Impedance Flow Cytometry with Cell-Sized Liposomes, ACS Sensors, June 2023, American Chemical Society (ACS),
DOI: 10.1021/acssensors.3c00533.
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