What is it about?
Here we summarize the development in the field of phosphatidylinositol 4-kinases (PI4Ks). PI4Ks are enzymes that produce a key lipid - phosphatidylinositol 4-phosphate (PI4P).
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Why is it important?
PI4Ks are hijacked by several +RNA viruses and the inhibition of PI4Ks leads to the arrest of viral replication. Thus, PI4Ks are recognized as a potential target for antivirals.
Perspectives
I hope this article provides a comprehensive yet concise overview of the PI4K field.
Evzen Boura
Institute of Organic Chemistry and Biochemistry
Read the Original
This page is a summary of: Phosphatidylinositol 4-kinases: Function, structure, and inhibition, Experimental Cell Research, October 2015, Elsevier,
DOI: 10.1016/j.yexcr.2015.03.028.
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