Adenovirus vectors targeting αV integrin or heparan sulfate receptors display different distribution of transgene activity after intramuscular injection

What is it about?

Replication-deficient adenoviral vectors have been largely employed in experimental and clinical applications for cardiovascular gene therapy. A limiting factor in the use of adenoviral vectors vectors is the relatively low transduction efficiency in some cell types, mainly caused by a limited expression of viral attachment and internalization receptors. This study demonstrate that altering adenoviral vector affinity for cellular receptors modulates the level and distribution of transgene activity, conferring characteristics that may allow for treatment customization.

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Photo by National Cancer Institute on Unsplash

Photo by National Cancer Institute on Unsplash