Optimization of composition of hydrogel to obtain maximum antimicrobial properties

What is it about?

In this paper, using a systematic review, we investigated the effect of materials’ concentration on final antibacterial activity and demonstrated that antibacterial property of wound dressings can be manipulated by changing polymer and antibacterial agents’ concentration. Based on the statistical analysis used in the article, we proposed a model for prediction of antibacterial susceptibility to prevent arbitrary selection of materials’ concentration. Our results demonstrated that this model could predict antibacterial activity with good precision, which can be further used in researches of not only engineers but also biologists.

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Why is it important?

Application of a biocompatible, antibacterial wound dressing is of great importance for proper wound healing in a patient. Up to now, a great effort has been done for fabrication of such dressing. However, there is still a lack of systematic investigation of the effect of materials’ concentration on final antibacterial activity.