2-Hydroxypyridinyl-Substituted-Oxadiazoles and -Triazoles

What is it about?

A complete study on the preparation of original halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones and their transformation into 1,2,4-oxadiazoles and 1,2,4-triazoles is presented. We also present the discovery of a new, rapid, and complementary access to 2-substituted 4H-benzo[e][1,3]oxazinones. Finally, the one-step transformation of some of these pyrido-oxazinones into the corresponding hydroxypyridyl-substituted 1,2,4-oxadiazoles and 1,2,4-triazoles was explored,

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Why is it important?

We report in this publication the preparation of original aromatic heterocycles that could constitute new scaffolds for medicinal chemists.