Expression pattern and prognostic significance of aldehyde dehydrogenase 2 in lung adenocarcinoma as a potential predictor of immunotherapy efficacy

What is it about?

The study investigates the association between the expression of the mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) and lung adenocarcinoma (LUAD), revealing that higher expression of ALDH2 is predictive of improved overall survival and correlates with immune cell infiltration, suggesting its potential as a predictive marker for immunotherapeutic response in LUAD. These results are particularly relevant for the high incidence in the East Asian population of the rs671 polymorphism that causes ALDH2 loss of function leading to increased alcohol sensitivity (Asian Flush Syndrome).

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Photo by Europeana on Unsplash

Photo by Europeana on Unsplash